Results 171 to 180 of about 144,883 (257)

Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects. [PDF]

Nat Commun
Brito Nunes C, Rukins V, Cisse AH, White F, McBride N, Kuang A, Allard C, Ronkainen J, Hughes A, Elliott A, Thorleifsson G, Vaudel M, Laisk T, Gu Y, Lamri A, Chen L, Tuhkanen J, Lahti J, Calas L, Muntaner M, Karhunen V, Choi J, Heiskala A, Hatem G, Fragoso-Bargas N, Rifas-Shiman SL, Paz-Lopez G, Stinson SE, Bhowmik B, Ahlqvist E, Estonian Biobank Research Team, Genes & Health Research Team, Deleuze JF, Eriksson JG, Park J, Teo K, Räikkönen K, Stefansson K, Molina-Vega M, Subbarao P, Beaumont RN, Johansson S, Tuomi T, Hansen T, Engelbrechtsen L, Morcillo S, Oken E, Quigstad E, Birkeland KI, Vääräsmäki M, Hattersley AT, Sebert S, Hitman GA, Kwak SH, Järvelin MR, Prasad RB, Heude B, Meirhaeghe A, Bouchard L, Jacques PÉ, Laivuori H, Tan KH, Anand SS, van Heel DA, Liu S, Njølstad PR, Steinthorsdottir V, Widén E, Keikkala E, Scholtens DM, Lowe WL, Finer S, Morris AP, Mägi R, Zöllner J, Borges MC, Lawlor DA, Hivert MF, Freathy RM, Evans DM, Moen GH.   +80 more
europepmc   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Polygenic Risk Scores for Breast Cancer Among African American Women With High Risk.

JAMA Netw Open
Sun Y, Simmons T, Li JL, Jamal A, Manirakiza AVC, Pruss D, Ratzel S, Olopade OI, Gutin A, Hughes E, Huo D.   +10 more
europepmc   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Publisher Correction: Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants. [PDF]

Genome Biol
Kim W, Hu X, Kim K, Chun S, Orchard P, Qiao D, Ruczinski I, Saferali A, Aguet F, Antonacci-Fulton L, Balte PP, Bartz TM, Anamika WJ, Zhou X, Duan J, Brody JA, Cade BE, Daviglus ML, Doddapaneni H, Dugan-Perez S, Dutcher SK, Frazar CD, Gabriel SB, Gharib SA, Gupta N, Hobbs BD, Kasela S, Loehr LR, Metcalf GA, Muzny DM, Oelsner EC, Rasmussen-Torvik LJ, Sitlani CM, Smith J, Sofer T, Xu H, Yu B, Zhang D, Ziniti J, Barr RG, Carson AP, Fornage M, Hou L, Kalhan R, Kaplan R, Lappalainen T, London SJ, Morrison AC, O'Connor GT, Psaty BM, Raffield LM, Redline S, Rich SS, Rotter JI, Silverman EK, Manichaikul A, Cho MH.   +56 more
europepmc   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Genetic determinants of childhood onset systemic lupus erythematosus. [PDF]

Lupus Sci Med
Nelson M, Murthy S, Maddipatla S, Shenoy S, Ponder L, Chandrakasan S, Kugathasan S, Cutler D, Prahalad S.   +8 more
europepmc   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Integrative Genomics Identifies Candidate Genes Underlying Trypanotolerance in Hybrid African Cattle. [PDF]

Evol Appl
McHugo GP, Ward JA, Ng'ang'a SI, Frantz LAF, Browne JA, Salter-Townshend M, O'Gorman GM, Meade KG, Hill EW, Hall TJ, MacHugh DE.   +10 more
europepmc   +1 more source