Results 11 to 20 of about 89,416 (252)

A quantitative approach to detect and overcome PCR inhibition in ancient DNA extracts

BioTechniques, 2009
Inhibition is problematic in many applications of PCR, particularly those involving degraded or low amounts of template DNA, when simply diluting the extract is undesirable. Two basic approaches to monitoring inhibition in such samples using real-time or
Christine E. King, Régis Debruyne, Melanie Kuch, Carsten Schwarz, Hendrik N. Poinar   +4 more
doaj   +1 more source

A new home for microbes

eLife, 2019
Modern microorganisms growing in fossils provide major challenges for researchers trying to detect ancient molecules in the same fossils.
Raphael Eisenhofer, Alan Cooper
doaj   +1 more source

Genetic characterisation of the North-West Indian populations: analysis of mitochondrial DNA control region variations

Annals of Human Biology, 2021
Background Human mitochondrial DNA presents several interesting characteristics, making it a favourable tool in the field of molecular anthropology, medical genetics, population history, and forensic science.
Gagandeep Singh, Srinivas Yellapu, Harkirat Singh Sandhu, Indu Sharma, Varun Sharma, A. J. S. Bhanwer   +5 more
doaj   +1 more source

Apolipoprotein E (APOE) Haplotypes in Healthy Subjects from Worldwide Macroareas: A Population Genetics Perspective for Cardiovascular Disease, Neurodegeneration, and Dementia

Current Issues in Molecular Biology, 2023
Human APOE is a 299-amino acid long protein expressed and secreted in several tissues and body districts, where it exerts different functions mainly related to lipid metabolism, with specific activities around cholesterol transport and absorption ...
Paolo Abondio, Francesco Bruno, Donata Luiselli   +2 more
doaj   +1 more source

Indigenous sex-selective salmon harvesting demonstrates pre-contact marine resource management in Burrard Inlet, British Columbia, Canada

Scientific Reports, 2021
To gain insight into pre-contact Coast Salish fishing practices, we used new palaeogenetic analytical techniques to assign sex identifications to salmonid bones from four archaeological sites in Burrard Inlet (Tsleil-Waut), British Columbia, Canada ...
Jesse Morin, Thomas C. A. Royle, Hua Zhang, Camilla Speller, Miguel Alcaide, Ryan Morin, Morgan Ritchie, Aubrey Cannon, Michael George, Michelle George, Dongya Yang   +10 more
doaj   +1 more source

Surveying the repair of ancient DNA from bones via high-throughput sequencing

BioTechniques, 2015
DNA damage in the form of abasic sites, chemically altered nucleotides, and strand fragmentation is the foremost limitation in obtaining genetic information from many ancient samples. Upon cell death, DNA continues to endure various chemical attacks such
Nathalie Mouttham, Jennifer Klunk, Melanie Kuch, Ron Fourney, Hendrik Poinar   +4 more
doaj   +1 more source

Microbiome applications for pathology: challenges of low microbial biomass samples during diagnostic testing

The Journal of Pathology: Clinical Research, 2020
The human microbiome can play key roles in disease, and diagnostic testing will soon have the ability to examine these roles in the context of clinical applications.
Caitlin A Selway, Raphael Eisenhofer, Laura S Weyrich   +2 more
doaj   +1 more source

Genomic Approaches for Conservation Management in Australia under Climate Change

Life, 2021
Conservation genetics has informed threatened species management for several decades. With the advent of advanced DNA sequencing technologies in recent years, it is now possible to monitor and manage threatened populations with even greater precision ...
Isabelle R. Onley, Katherine E. Moseby, Jeremy J. Austin   +2 more
doaj   +1 more source

Twenty-Seven Y-Chromosome Short Tandem Repeats Analysis of Italian Mummies of the 16th and 18th Centuries: An Interdisciplinary Research

Frontiers in Genetics, 2021
Roccapelago (MO) is a small village located in the Northern Central Apennines, with a population of 31 inhabitants (2014). In 2010, more than 400 individuals dated between the end of the 16th and the 18th century, many of which partially mummified, were ...
Carla Bini, Elisabetta Cilli, Stefania Sarno, Mirko Traversari, Francesco Fontani, Alessio Boattini, Susi Pelotti, Donata Luiselli   +7 more
doaj   +1 more source

Exploring relationships between host genome and microbiome: new insights from genome-wide association studies.

Frontiers in Microbiology, 2016
As our understanding of the human microbiome expands, impacts on health and disease continue to be revealed. Alterations in the microbiome can result in dysbiosis, which has now been linked to subsequent autoimmune and metabolic diseases, highlighting ...
Muslihudeen Abdul-Razaq Abdul-Aziz, Alan Cooper, Laura S. Weyrich   +2 more
doaj   +1 more source