Results 21 to 30 of about 2,093,063 (290)

Epigenetics of Ancient DNA [PDF]

Acta Naturae, 2016
Initially, the study of DNA isolated from ancient specimens had been based on the analysis of the primary nucleotide sequence. This approach has allowed researchers to study the evolutionary changes that occur in different populations and determine the influence of the environment on genetic selection.
ZHENILO S.V., SOKOLOV A.S., PROKHORTCHOU E.B.   +2 more
openaire   +2 more sources

A quantitative approach to detect and overcome PCR inhibition in ancient DNA extracts

BioTechniques, 2009
Inhibition is problematic in many applications of PCR, particularly those involving degraded or low amounts of template DNA, when simply diluting the extract is undesirable. Two basic approaches to monitoring inhibition in such samples using real-time or
Christine E. King, Régis Debruyne, Melanie Kuch, Carsten Schwarz, Hendrik N. Poinar   +4 more
doaj   +1 more source

Preferential access to genetic information from endogenous hominin ancient DNA and accurate quantitative SNP-typing via SPEX [PDF]

, 2009
The analysis of targeted genetic loci from ancient, forensic and clinical samples is usually built upon polymerase chain reaction (PCR)-generated sequence data.
Endicott, Phillip, Sanchez, J., Cooper, Alan, Endicott, P., Brotherton, Paul, Sanchez, Juan J, Brotherton, P., Sanchez, Juan J., Cooper, A.   +8 more
core   +1 more source

A new home for microbes

eLife, 2019
Modern microorganisms growing in fossils provide major challenges for researchers trying to detect ancient molecules in the same fossils.
Raphael Eisenhofer, Alan Cooper
doaj   +1 more source

Molecular Identification of Bacteria by Total Sequence Screening: Determining the Cause of Death in Ancient Human Subjects [PDF]

, 2011
Research of ancient pathogens in ancient human skeletons has been mainly carried out on the basis of one essential historical or archaeological observation, permitting specific pathogens to be targeted.
Alekseev, Anatoly, Alekseev, Anatoly N., Thèves, Catherine, Dabernat, Henri, François Xavier Ricaut, Fabre Richard, Alekseev, Anatoly N, Crubézy, Eric, Anatoly N Alekseev, Eric Crubézy, Alice Senescau, Vanin Stefano, Dabernat Henri, Crubézy Eric, Keyser, Christine, Fabre, Richard, Bertrand Ludes, Senescau Alice, Ludes Bertrand, Senescau, Alice, Ricaut François Xavier, Vanin, Stefano, Richard Fabre, Ludes, Bertrand, Catherine Thèves, Christine Keyser, Stefano Vanin, Adler, Ben, Ricaut, François-Xavier, Alekseev Anatoly N., Anatoly N. Alekseev, Ricaut, François Xavier, Keyser Christine, Henri Dabernat, Thèves Catherine   +34 more
core   +1 more source

Genetic characterisation of the North-West Indian populations: analysis of mitochondrial DNA control region variations

Annals of Human Biology, 2021
Background Human mitochondrial DNA presents several interesting characteristics, making it a favourable tool in the field of molecular anthropology, medical genetics, population history, and forensic science.
Gagandeep Singh, Srinivas Yellapu, Harkirat Singh Sandhu, Indu Sharma, Varun Sharma, A. J. S. Bhanwer   +5 more
doaj   +1 more source

Apolipoprotein E (APOE) Haplotypes in Healthy Subjects from Worldwide Macroareas: A Population Genetics Perspective for Cardiovascular Disease, Neurodegeneration, and Dementia

Current Issues in Molecular Biology, 2023
Human APOE is a 299-amino acid long protein expressed and secreted in several tissues and body districts, where it exerts different functions mainly related to lipid metabolism, with specific activities around cholesterol transport and absorption ...
Paolo Abondio, Francesco Bruno, Donata Luiselli   +2 more
doaj   +1 more source

Microbiome applications for pathology: challenges of low microbial biomass samples during diagnostic testing

The Journal of Pathology: Clinical Research, 2020
The human microbiome can play key roles in disease, and diagnostic testing will soon have the ability to examine these roles in the context of clinical applications.
Caitlin A Selway, Raphael Eisenhofer, Laura S Weyrich   +2 more
doaj   +1 more source

Indigenous sex-selective salmon harvesting demonstrates pre-contact marine resource management in Burrard Inlet, British Columbia, Canada

Scientific Reports, 2021
To gain insight into pre-contact Coast Salish fishing practices, we used new palaeogenetic analytical techniques to assign sex identifications to salmonid bones from four archaeological sites in Burrard Inlet (Tsleil-Waut), British Columbia, Canada ...
Jesse Morin, Thomas C. A. Royle, Hua Zhang, Camilla Speller, Miguel Alcaide, Ryan Morin, Morgan Ritchie, Aubrey Cannon, Michael George, Michelle George, Dongya Yang   +10 more
doaj   +1 more source

Surveying the repair of ancient DNA from bones via high-throughput sequencing

BioTechniques, 2015
DNA damage in the form of abasic sites, chemically altered nucleotides, and strand fragmentation is the foremost limitation in obtaining genetic information from many ancient samples. Upon cell death, DNA continues to endure various chemical attacks such
Nathalie Mouttham, Jennifer Klunk, Melanie Kuch, Ron Fourney, Hendrik Poinar   +4 more
doaj   +1 more source