Results 61 to 70 of about 267,934 (293)

Quantifying variations associated with dental caries reveals disparity in effect allele frequencies across diverse populations

BMC Genomic Data
Background Dental caries (DC) is a multifaceted oral condition influenced by genetic and environmental factors. Recent advancements in genotyping and sequencing technologies, such as Genome-Wide Association Studies (GWAS) have helped researchers to ...
Sangram Sandhu, Varun Sharma, Sachin Kumar, Niraj Rai, Pooran Chand   +4 more
doaj   +1 more source

Ancient bone DNA amplified [PDF]

Nature, 1989
Reports the successful extraction and amplification of DNA from human bones between 300 and 5500 years of age. Genetic information can be recovered from ancient skeletal material if contamination by modern DNA is avoided. Describes experimental technique and results on a range of bone samples.
E, Hagelberg, B, Sykes, R, Hedges
openaire   +2 more sources

Precise Construction of an Antimicrobial Peptide Targeting Bacterial Cell Membranes Derived From Natural Peptides

Advanced Science, EarlyView.
An AMP (P 3‐3R‐8I) based on natural peptides, which can target bacterial cell membranes, was precisely constructed via amino acid mutation. P 3‐3R‐8I exhibits antibacterial capability which could be attributed to the ability of P 3‐3R‐8I to quickly penetrate bacterial cell membranes and then to bind to bacterial DNA.
Jiaqi Huang, Bohao Liu, Xingzhuo Zhu, Deqian Qiao, Sizhe Chen, Xiaoyan Zeng, Qingqing Yang, Zihuan Wei, Yinjuan Huang, Jizhao Wang, Guangjian Zhang, Qiuyu Gong   +11 more
wiley   +1 more source

A new model for ancient DNA decay based on paleogenomic meta-analysis [PDF]

, 2017
The persistence of DNA over archaeological and paleontological timescales in diverse environments has led to a revolutionary body of paleogenomic research, yet the dynamics of DNA degradation are still poorly understood.
Allentoft, Allentoft, Briggs, Campos, Cassidy, Dabney, Deagle, Demarchi, Dodt, Enk, Frantz, Gallego Llorente, Gamba, Gilbert, Grass, Green, Günther, Haak, Haber, Hansen, Hijmans, Hijmans, Hofman, Hofmanová, Jeong, Jónsson, Keller, Kistler, Kistler, Koslicki, Leonardi, Li, Li, Librado, Logan Kistler, Lynch, Martiniano, Matthew Collins, Miller, Olalde, Olalde, Oliver Smith, Orlando, Orlando, Ornstein, Ottoni, Paabo, Palkopoulou, Palmer, Park, Pedersen, Plummer, Poinar, Pääbo, R Development Core Team, Rasmussen, Rasmussen, Robin G. Allaby, Roselyn Ware, Sawyer, Schmitt, Schubert, Shapiro, Skoglund, Skoglund, Smith, Wade, Wales, Wang, Warinner, Weiß, Yoshida, Zhang   +72 more
core   +4 more sources

Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Advanced Science, EarlyView.
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao‐Lin Chen, Deng Chen   +6 more
wiley   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source

Evaluating the roles of directed breeding and gene flow in animal domestication [PDF]

, 2014
Peer ...
Capriles, Jose M., Denham, Tim, Dobney, Keith, Marshall, Fiona B.   +3 more
core   +1 more source

Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants

Advanced Science, EarlyView.
ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter, Verena Gaugler, Sara Christina Stolze, Riya Ghosh, Akhila Jayamon, Ranjana Yadav, Felix Wollensack, Debabrata Laha, Hirofumi Nakagami, Gabriel Schaaf, Henning Jacob Jessen   +10 more
wiley   +1 more source

Epigenetics of Ancient DNA [PDF]

Acta Naturae, 2016
Initially, the study of DNA isolated from ancient specimens had been based on the analysis of the primary nucleotide sequence. This approach has allowed researchers to study the evolutionary changes that occur in different populations and determine the influence of the environment on genetic selection.
ZHENILO S.V., SOKOLOV A.S., PROKHORTCHOU E.B.   +2 more
openaire   +2 more sources