Results 81 to 90 of about 271,635 (292)

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

open access: yesAdvanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen   +9 more
wiley   +1 more source

A CLE11b‐CLE16 Signaling Relay Mediates Root‐Shoot‐Root Crosstalk for Drought Adaptation in Common Bean

open access: yesAdvanced Science, EarlyView.
A novel root‐shoot‐root signaling relay, mediated by CLE peptides, coordinates drought adaptation in common bean. Root‐derived PvCLE11b translocates acropetally to leaves, inducing PvCLE16 expression via PvTCP10. Leaf‐accumulated PvCLE16 triggers stomatal closure and translocates basipetally to modulate root architecture.
Xinyang Wu   +12 more
wiley   +1 more source

Polymerase Chain Reaction. Perturbation Theory and Machine Learning Artificial Intelligence‐Experimental Microbiome Analysis: Applications to Ancient DNA and Tree Soil Metagenomics Cases of Study

open access: yesAdvanced Intelligent Systems, EarlyView.
The polymerase chain reaction (PCR).Perturbation Theory and Machine Learning framework integrates perturbation theory and machine learning to classify genetic sequences, distinguishing ancient DNA from modern controls and predicting tree health from soil metagenomic data.
Jose L. Rodriguez   +19 more
wiley   +1 more source

Discovery of the Principal Cystic Fibrosis Mutation (F508del) in Ancient DNA from Iron Age Europeans [PDF]

open access: yes, 2007
The most common, life-threatening autosomal recessive disease of Europeans and Euro-Americans, cystic fibrosis (CF), occurs predominately in patients with the F508del mutation.1 Although F508del is currently detectable as a single allele in 1/30-1/40 ...
Cedric Le Marechal   +4 more
core   +1 more source

Phylogenomics reveals the evolution of floral traits associated with pollinators and pollinator–prey conflict within the carnivorous Pinguicula subgenus Temnoceras

open access: yesAmerican Journal of Botany, EarlyView.
Abstract Premise The carnivorous plant genus Pinguicula (Lentibulariaceae) exhibits remarkable floral diversity associated with pollination, particularly in the largest subgenus Temnoceras, which spans Mexico and Central America. Despite this diversity, the relationships between species and the evolution of key floral traits remain unresolved. Here, we
Yunjia Liu   +5 more
wiley   +1 more source

Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens. [PDF]

open access: yes, 2016
BACKGROUND: Plants deploy immune receptors to detect pathogen-derived molecules and initiate defense responses. Intracellular plant immune receptors called nucleotide-binding leucine-rich repeat (NLR) proteins contain a central nucleotide-binding (NB ...
Cevik, Volkan   +4 more
core   +11 more sources

Differences in cynomolgus macaque populations used for infectious disease research

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Cynomolgus macaques, a species of Old World primate native to southeastern and eastern Asia and the island of Mauritius, are one of the most important nonhuman primate models for infectious disease. Research into the population genetics of cynomolgus macaques has found significant differences between macaques native to different areas, particularly ...
Darcy Quist   +4 more
wiley   +1 more source

Ontogenetic changes and sexual dimorphism in the cranium and mandible of the Atlantic walrus (Odobenus rosmarus rosmarus L.)

open access: yesThe Anatomical Record, EarlyView.
Abstract Walruses have been an important subsistence and cultural resource for humans and have been exploited for millennia across their distribution. This exploitation has contributed to severe declines in several populations and local extirpations.
Katrien Dierickx   +6 more
wiley   +1 more source

Optimized in-solution enrichment of over a million ancient human SNPs

open access: yesGenome Biology
Background In-solution hybridization enrichment of genetic markers is a method of choice in paleogenomic studies, where the DNA of interest is generally heavily fragmented and contaminated with environmental DNA, and where the retrieval of genetic data ...
Roberta Davidson   +23 more
doaj   +1 more source

MassARRAY-based single nucleotide polymorphism analysis in breast cancer of north Indian population

open access: yesBMC Cancer, 2020
Background Breast Cancer (BC) is associated with inherited gene mutations. High throughput genotyping of BC samples has led to the identification and characterization of biomarkers for the diagnosis of BC.
Divya Bakshi   +12 more
doaj   +1 more source

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