Results 91 to 100 of about 44,807,161 (294)

Information and knowledge: an evolutionary framework for information science

open access: yesInformation Research: An International Electronic Journal, 2005
Background. Many definitions of information, knowledge, and data have been suggested throughout the history of information science. In this article, the objective is to provide definitions that are usable for the physical, biological, and social meanings
Marcia J. Bates
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

The Place of Library Science and Information-Documentation Science in Information Science

open access: yes, 1973
(The author) is German and is now considered one of the leading international scholars and specialists in information science. After being developed and transformed into the "Institute of Scientific Librarianship and Information" in 1966, the Institute of Librarianship at Humboldt University-Berlin organized a colloquium entitled "The Subject and ...
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The information literacy framework: case studies of successful implementation Association for Library and Information Science Education series./ edited by Heidi Julien, Melissa Gross, Don Latham.

open access: yes, 2020
Includes bibliographical references and index."This edited book helps demystify how to incorporate ACRL's Framework for Information Literacy for Higher Education into information literacy instruction in higher education as well as how to teach the new ...
Gross Melissa   +2 more
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Quantum Information Science [PDF]

open access: yesIEEE Internet Computing, 2022
Melanie Swan   +2 more
openaire   +3 more sources

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