An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Perceptions of employers in South Africa on library and information science graduates' skills, knowledge and competencies on digital scholarship. [PDF]
Heliyon, 2023 Sibiya PT, Ngulube P.
europepmc +1 more source
Islamic World Science Citation Center's Journal Citation Reports (JCR) [PDF]
, 2016 This article gives an overview of the Islamic World Science Citation Center's (ISC) Journal Citation Reports (JCR) database. ISC-JCR is the only source of citation data on Islamic countries’ leading journals and covers journals in English, Arabic and ...
Safahieh, Hajar; Regional information center for science and technology
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Prediction of Research Hotspots Based on LSTM: Taking Information Science as Example. [PDF]
Comput Intell Neurosci, 2022 Xiang F.
europepmc +1 more source
Needs and challenges with respect to establishing a collaboratory within library and information science: Practioners' perspectives [PDF]
, 2006 This paper reports on a study that explored the needs and challenges with respect to the creation of a collaboratory for library and information science practitioners.
Sonnenwald, Diane H. +6 more
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Expanding the Chemical Information Science gateway. [PDF]
F1000Res, 2021 Medina-Franco JL.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source