Results 171 to 180 of about 44,807,161 (294)

The role of information science within the clinical translational science ecosystem. [PDF]

open access: yesJ Clin Transl Sci
Ragon B   +22 more
europepmc   +1 more source

Proceedings of the Arizona-Nevada Academy of Science (1963)

open access: yes, 1963
SEVENTH ANNUAL MEETING / March 30, 1963 / Joint Meeting with the Pacific Division of the American Association for the Advancement of Science / University of Arizona / Tucson, ArizonaThis volume is part of the Arizona-Nevada Academy of Science collections.
Arizona-Nevada Academy of Science
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Proceedings of the Arizona-Nevada Academy of Science (1966)

open access: yes, 1966
TENTH ANNUAL MEETING / April 2, 1966 / Joint Meeting with the Pacific Division of the American Association for the Advancement of Science / Arizona State University / Tempe, ArizonaThis volume is part of the Arizona-Nevada Academy of Science collections.
Arizona-Nevada Academy of Science
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

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