Results 21 to 30 of about 2,458 (176)

Ceftolozane/Tazobactam for Resistant Drugs Pseudomonas aeruginosa Respiratory Infections: A Systematic Literature Review of the Real-World Evidence [PDF]

Life, 2021
Background: Ceftolozane/tazobactam (C/T) is a β-lactam/β-lactamase inhibitor combination that mainly targets Gram-negative bacteria. The current international guidelines recommend including C/T treatment in the empirical therapy for hospital-acquired ...
Luca Gregorio Giaccari, Maria Caterina Pace, Maria Beatrice Passavanti, Francesca Gargano, Caterina Aurilio, Pasquale Sansone   +5 more
doaj   +3 more sources

Trends in Antimicrobial Resistance at a Greek Tertiary Hospital over a 7-Year Period, Including the COVID-19 Pandemic [PDF]

Antibiotics
Background/Objectives: Antimicrobial resistance (AMR) remains a major global threat, with the COVID-19 pandemic influencing its dynamics, although its overall impact remains uncertain.
Eleni Mylona, Sofia Kostourou, Dimitroula Giankoula, Efthimia Spyrakou, Nektaria Michopanou, Chrysoula Kolokotroni, Maria Papagianni, Dimitris Kounatidis, Efstathia Perivolioti, Vasileios Papastamopoulos   +9 more
doaj   +2 more sources

Efficacy of colistin-based combinations against pandrug-resistant whole-genome-sequenced Klebsiella pneumoniae isolated from hospitalized patients in Egypt: an in vitro/vivo comparative study [PDF]

Gut Pathogens
Background Colistin resistance significantly constrains available treatment options and results in the emergence of pandrug-resistant (PDR) strains. Treating PDR infections is a major public health issue. A promising solution lies in using colistin-based
Eriny T. Attalla, Amal M. Khalil, Azza S. Zakaria, Rhiannon Evans, Nesrin S. Tolba, Nelly M. Mohamed   +5 more
doaj   +2 more sources

Trends of Antibiotic Resistance Patterns and Bacteriological Profiles of Pathogens Associated with Genitourinary Infections in Secondary Healthcare Facilities in the Volta Region of Ghana. [PDF]

Pathogens
Urogenital infections contribute greatly to both hospital- and community-acquired infections. In Ghana, the prevalence of resistance to commonly used antibiotics is relatively high.
Odoi H, Opoku N, Adusei B, Danquah K, Vordzogbe G, Mayer D, Hutton-Nyameaye A, Jato J, Somuah SO, Orman E, Ben IO, Aku TA, Sewornu R, Panesar P, Jani YH, Dodoo CC.   +15 more
europepmc   +3 more sources

Incidence and Antibiotic Susceptibility of Gram-Negative Bacteria Associated With Chest Infections in Intensive Care Unit Patients From a Selected Hospital in the Kingdom of Saudi Arabia. [PDF]

Biomed Res Int
Background Hospital‐acquired pneumonia (HAP), including ventilator‐associated pneumonia (VAP), is a leading cause of morbidity and mortality in intensive care units (ICUs). Local, organism‐specific antimicrobial resistance data are critical to guide empiric therapy and strengthen antimicrobial stewardship efforts.
Almouwlid A, Albenasy K, Kamel Y, Abdelmoktader A, Alaidarous M, Abdel-Hadi A.   +5 more
europepmc   +2 more sources

Emergence of ST63 Pandrug-Resistant Acinetobacter pittii Isolated From an AECOPD Patient in China

Frontiers in Cellular and Infection Microbiology, 2021
Acinetobacter sp. is among the ESKAPE organisms which represent the major nosocomial pathogens that exhibited a high resistance rate. A. pittii, frequently associated with antimicrobial resistance particularly to carbapenems, is one of the most common ...
Ling Yang, Ning Dong, Chen Xu, Chen Xu, Lianwei Ye, Sheng Chen   +5 more
doaj   +1 more source

Increasing antimicrobial resistance in nosocomial pathogens; multidrug-resistant extensively drug-resistant and pandrug-resistant Acinetobacter baumannii [PDF]

Journal of Microbiology and Infectious Diseases, 2014
Objective: The aim of this study was to determine the antimicrobial susceptibility of Acinetobacter baumannii strains, which were isolated from nosocomial infections and compare the changes in resistance rates of isolates over time.Methods: Acinetobacter
Cem Celik, Mustafa Gokhan Gozel, Fatma Dayı, Mustafa Zahir Bakıcı, Nazif Elaldı, Esra Gulturk   +5 more
doaj   +2 more sources

Evaluation of blaGES-5 and bla veb-1 genes with multidrug-resistant extend, pandrug resistance patterns (MDR, XDR, PDR), and biofilm formation in Pseudomonas aeruginosa isolates

Cellular and Molecular Biology, 2021
Pseudomonas aeruginosa is a ubiquitous microorganism that is difficult to treat due to the increasing prevalence of multidrug resistance patterns. A total of 227 samples were taken from different clinical samples during the study period from January 2018 to December 2018. The isolates were identified with antibiotic sensitivity testing with ESBL by the
Fattma A, Ali, Sevan Hassan, Bakir, Sayran Hamed, Haji, Bashdar M, Hussen   +3 more
openaire   +3 more sources

Mortality of Pandrug-Resistant Klebsiella pneumoniae Bloodstream Infections in Critically Ill Patients: A Retrospective Cohort of 115 Episodes

Antibiotics, 2021
Background: The increased frequency of bacteraemias caused by pandrug-resistant Klebsiella pneumoniae (PDR-Kp) has significant implications. The aim of the present study was to identify predictors associated with mortality of PDR-Kp bacteraemias. Methods:
Matthaios Papadimitriou-Olivgeris, Christina Bartzavali, Alexandra Georgakopoulou, Fevronia Kolonitsiou, Chrisavgi Papamichail, Iris Spiliopoulou, Myrto Christofidou, Fotini Fligou, Markos Marangos   +8 more
doaj   +1 more source

High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy

Scientific Reports, 2022
The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily increased with increased colistin usage for treating carbapenem-resistant K ...
Aye Mya Sithu Shein, Dhammika Leshan Wannigama, Paul G. Higgins, Cameron Hurst, Shuichi Abe, Parichart Hongsing, Naphat Chantaravisoot, Thammakorn Saethang, Sirirat Luk-in, Tingting Liao, Sumanee Nilgate, Ubolrat Rirerm, Naris Kueakulpattana, Sukrit Srisakul, Apichaya Aryukarn, Matchima Laowansiri, Lee Yin Hao, Manta Yonpiam, Naveen Kumar Devanga Ragupathi, Teerasit Techawiwattanaboon, Natharin Ngamwongsatit, Mohan Amarasiri, Puey Ounjai, Rosalyn Kupwiwat, Phatthranit Phattharapornjaroen, Vishnu Nayak Badavath, Asada Leelahavanichkul, Anthony Kicic, Tanittha Chatsuwan   +28 more
doaj   +1 more source