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Clinical Outcomes of Pandrug-Resistant Versus Carbapenem-Resistant, Colistin-Susceptible Acinetobacter baumannii Infections: A Retrospective Analysis of a Prospective Multicentre Cohort [PDF]

Antibiotics
Background: Pandrug-resistant (PDR) Acinetobacter baumannii represents a major therapeutic challenge in regions where carbapenem-resistant A. baumannii (CRAB) is endemic.
Ilias Karaiskos, George L. Daikos, Sofia Michelidou, Christina Mouratidou, Alexandra Gavala, Aikaterini Gkoufa, Aikaterini Sakagianni, Eleni Mouloudi, Evdoxia Tsigou, Christina Routsi, Stamatis Karakonstantis, Christina Stamatopoulou, Despina Markantonaki, Foteini Veroniki, Maria Pirounaki, Anna Kyriakoudi, Sevasti Ampelioti, Charalambos Anastogiannis, Antonia Koutsoukou, Helen Giamarellou, Konstantinos Pontikis   +20 more
doaj   +3 more sources

Clinical treatment of pandrug-resistant bacterial infection consulted by clinical pharmacist [PDF]

Saudi Pharmaceutical Journal, 2015
Objective Pandrug-resistant (PDR) bacterial infections are associated with considerable prolongation of hospitalization and mortality in clinical practice. Method This case-series study was conducted during a 3-year period from 2011 to 2013.
Yang Zhi-Wen, Zhang Yan-Li, Yuan Man, Fang Wei-Jun   +3 more
doaj   +3 more sources

Current and Potential Therapeutic Options for Infections Caused by Difficult-to-Treat and Pandrug Resistant Gram-Negative Bacteria in Critically Ill Patients

Antibiotics, 2022
Carbapenem resistance in Gram-negative bacteria has come into sight as a serious global threat. Carbapenem-resistant Gram-negative pathogens and their main representatives Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa are ...
Helen Giamarellou, Ilias Karaiskos
doaj   +4 more sources

Outcome of infections due to pandrug-resistant (PDR) Gram-negative bacteria

BMC Infectious Diseases, 2005
Background The increasing problem of infections due to multidrug-resistant Gram-negative bacteria has led to re-use of polymyxins in several countries.
Bliziotis Ioannis A, Kasiakou Sofia K, Falagas Matthew E, Samonis George, Athanassopoulou Panayiota, Michalopoulos Argyris   +5 more
doaj   +3 more sources

Whole-genome profiling of antimicrobial resistance and virulence determinants in extensively-drug resistant Pseudomonas aeruginosa isolates causing ventilator associated pneumonia in Egypt [PDF]

BMC Infectious Diseases
Among critically ill ICU patients under prolonged mechanical ventilation, Pseudomonas aeruginosa is one of the most common cause of ventilator-associated pneumonia (VAP), with antimicrobial pressure leading to emergence of multidrug, extensively drug and
Sabah M. Alkhawagah, Shaimaa Elattar, Asmaa A. Elmadbouly, Shimaa A. Abdel Salam, Fatma A. Ahmed, Hala Sabry Alsaedy, Ahmed F. Gad, Hossam I. Gebeer, Mohamed G. Seadawy   +8 more
doaj   +2 more sources

Comparative clinical outcomes of pandrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae infections in children [PDF]

BMC Infectious Diseases
Background The global rise of antimicrobial resistance has become a major public health concern. However, data on the clinical course and outcomes of infections caused by pandrug-resistant (PDR) bacteria in children remain limited.
İrem Ceren Erbaş, Şilem Özdem Alataş, Ayşe Çakıl Güzin, Hatice Karaoğlu Asrak, Elif Alaçam, Ayşen Hazal Buran, Mahmut Cem Ergon, Nurşen Belet   +7 more
doaj   +2 more sources

Extensively Drug-Resistant (XDR) and Pandrug-Resistant (PDR) Acinetobacter baumannii as Sentinel Indicators of Cumulative System-Level Antimicrobial Pressure in Iraqi Burn and High-Risk Hospital Units [PDF]

Microorganisms
Antimicrobial resistance (AMR) is one of the most significant threats to healthcare systems, particularly in low- and middle-income nations where infection prevention and control, antimicrobial stewardship, and laboratory surveillance might not be ...
Sarah Ahmed Hasan, Ali Hasan Mohamed, Gulbahar F. Karim   +2 more
doaj   +2 more sources

The 'Health Collapse Spiral': A 35-Month Longitudinal Case Study of Physiological Reserve Depletion in a Centenarian Following COVID-19. [PDF]

Clin Case Rep
ABSTRACT This 35‐month case report documents irreversible physiological reserve depletion in a centenarian multimorbid man after COVID‐19. Prior to infection, he maintained precarious homeostasis for 17 years despite severe frailty (CFS 7), with stable CKD stage 3a (eGFR 58.3 mL/min/1.73 m2) and albumin 36.2 g/L.
Xu S, Zhang W, Yin Q, Wei J, Ma Y, Jia W.   +5 more
europepmc   +2 more sources

Characteristics and risk factors of postoperative pneumonia after emergency surgery in tertiary general hospitals (2015–2024): a 10-year comparative analysis with elective surgery [PDF]

Frontiers in Public Health
ObjectiveTo analyze the characteristics and risk factors of postoperative pneumonia (POP) in emergency surgery at tertiary general hospitals, aiming to provide scientific evidence for early screening of high-risk populations and optimization of POP ...
Zhenzhen Wu, Zhenzhen Wu, Zhigang Zheng, Zhenghao Yu, Xiaoli Wu, Yunxi Liu, Mingmei Du, Hongwu Yao, Yanling Bai   +8 more
doaj   +2 more sources

A Novel Real-Time SYBR Green PCR Assay for Integron Profiling in Pseudomonas aeruginosa: Unveiling the Resistance Nexus Between Food and Clinical Isolates [PDF]

Pathogens
Background: The dissemination of extensively drug-resistant Pseudomonas aeruginosa strains across the human–food interface represents a critical threat to global public health, complicating empirical therapeutic choices and challenging traditional ...
Hend Emad, Mahmoud M. Amer, Munirah M. Alhammadi, Mona Alharbi, Yasmen F. Mahran, Attia A. Attia, Khalid Maniah, Azza SalahEldin El-Demerdash   +7 more
doaj   +2 more sources