Results 61 to 70 of about 9,614 (214)

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Catalytic Sulfur‐Atom Transfer Enabled by a Bis(disulfide) Titanium Complex

Angewandte Chemie International Edition, EarlyView.
Multi‐electron transformations with titanium are underexplored due to limited access to low‐valent precursors. The four‐electron activation of elemental sulfur by a Ti(IV) complex yields a rare titanium bis(disulfide) complex, enabling the efficient catalytic synthesis of isothiocyanates from isonitriles under mild conditions.
Sebastian Samir Cremer, Peter Coburger, Corinna Czernetzki, Gabriele Hierlmeier   +3 more
wiley   +1 more source

Statistical shape modeling of the human inner ear through micro‐computed tomography imaging

The Anatomical Record, EarlyView.
In this study, 54 cadaveric temporal bone specimens underwent high‐resolution micro‐CT imaging. Images were semi‐automatically segmented and converted to 3D surface mesh models for morphological measurement and analysis. Statistical shape models were created for the inner ear, cochlea, and vestibular system, as well as for sex‐ and side‐based subgroups.
Carmine Spedaliere, Alexandra Vaupotic, Jaehyun Hwang, Khalil Husein, Mustafa Hafidh, Kyle Rioux, S. Alireza Rohani, Sumit K. Agrawal, Hanif M. Ladak   +8 more
wiley   +1 more source

Descriptive, comparative, and functional anatomy of the facial musculature in cattle (Bos taurus)

The Anatomical Record, EarlyView.
Abstract Facial expressions can provide insight into animal emotions and pain, but no standardized system for assessing the entire facial display in cattle (Bos taurus Linnaeus) exists. The Facial Action Coding System (FACS), originally developed for humans, identifies distinct facial movements based on mimetic muscles.
Maja Söderlind, Bridget Cain, Katrina Ask, Jean‐Francois Valarcher, Elin Hernlund, Pia Haubro Andersen, Marie Rhodin   +6 more
wiley   +1 more source

Quantitative muscle architecture in large carnivorous marsupials (Marsupialia: Dasyuridae) and links to substrate use and prey processing

The Anatomical Record, EarlyView.
Abstract The Dasyurid species Sarcophilus harrisii, Dasyurus maculatus, and Dasyurus viverrinus, occupying diverse ecological niches and forming a guild structure in Tasmania, provide a basis for examining the roles of various forelimb muscle groups in prey capture and locomotion.
Riya G. Bidaye, Samuel H. Frenkel, David P. Hocking, Alistair R. Evans, Justin W. Adams   +4 more
wiley   +1 more source

Infant Reflux Trial: study protocol for a multicentre randomized controlled trial on the treatment of gastroesophageal reflux disease in infants

Trials
Background Gastroesophageal reflux disease (GERD) is a common condition in infants below 1 year of age. Symptoms include frequent regurgitation, failure to thrive, food refusal, irritability, and back arching. While many infants experience some degree of
Natalia Krantz Barkholt, Kasper Dalby, Christian Backer Mogensen, Gitte Zachariassen, Josefine Gradman   +4 more
doaj   +1 more source

Estimating in vivo midfoot and hindfoot joint locations using external skin markers

The Anatomical Record, EarlyView.
Abstract Musculoskeletal modeling offers a non‐invasive approach to analyze human movement, enabling estimation of forces that are difficult to measure experimentally. In musculoskeletal modeling, the human body is represented as rigid segments connected by joints.
Steven G. Lautzenheiser, Christine M. Harper   +1 more
wiley   +1 more source

Poxyaibamberus Andersen & Dantas, gen. nov. (Diptera, Chironomidae, Orthocladiinae) from Brazil [PDF]

ZooKeys
Poxyaibamberus Andersen & Dantas, gen. nov. is erected based on the males of two species, P. jamanximensis Andersen & Dantas, sp. nov. from Jamanxim National Park, Pará State, Brazil, and P. ubajarensis Andersen & Dantas, sp. nov.
Trond Andersen, Galileu P. S. Dantas, Viktor Baranov, Annui M. Sanz-laParra, Humberto F. Mendes, Neusa Hamada   +5 more
doaj   +3 more sources

Reclaiming Andersen

, 2021
Helena Březinová, Slavíci, mořské víly a bolavé zuby. Pohádky H.Ch. Andersena: mezi romantismem a modernitou [Nightingales, Mermaids, and Toothaches: Andersen’s Fairy Tales between Romanticism and Modernity]. Brno: Host, 2018. 328 pp. ISBN 978-80-7577-612-9.
openaire   +2 more sources

Type I interferon drives dysfunction of a distinct CD8+ HLA‐DRB1+ T cell subset in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by type I interferon (IFN) signaling and adaptive immune dysregulation. We previously identified hypomethylation of HLA‐DRB1 and STAT1 in SLE CD8+ T cells, enabling aberrant IFN‐driven HLA‐DRB1 expression and expansion of a distinct CD8+ T cell subset. This study characterized CD8+ HLA‐DRB1+
Huizhong Long, Elio Carmona, Mikhail G Dozmorov, Amr H Sawalha   +3 more
wiley   +1 more source