Results 111 to 120 of about 389,574 (340)
Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR [PDF]
, 2014 Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Hay, Colin W +5 more
core +2 more sources
Advanced Science, EarlyView.This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu +12 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu +9 more
wiley +1 more source
The Role of Androgen Receptor Signaling in Ovarian Cancer
Cells, 2019 Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor
Taichi Mizushima, Hiroshi Miyamoto
doaj +1 more source
Modulation of the cytosolic androgen receptor in striated muscle by sex steroids [PDF]
The influence of orchiectomy (GDX) and steroid administration on the level of the cytosolic androgen receptor in the rat levator ani muscle and in rat skeletal muscles (tibialis anterior and extensor digitorum longus) was studied.
Max, S. E., Rance, N. E.
core +1 more source
Androgens and Female Sexuality: Molecular Insights, Neuroendocrine Crosstalk and Future Therapeutic Directions [PDF]
, 2023 Giulia Montan +11 more
openalex +1 more source
Androgen receptor dysfunction in human androgen insensitivity
Trends in Endocrinology & Metabolism, 1995 The androgen insensitivity syndromes comprise a spectrum of phenotypic abnormalities in male sex differentiation and development that result from target tissue resistance to androgen action due to molecular lesions in the X-chromosome-linked androgen receptor gene.
openaire +2 more sources
Advanced Science, EarlyView.Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside +11 more
wiley +1 more source
Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]
, 2009 Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H. +4 more
core +1 more source