Results 111 to 120 of about 378,224 (340)
Overexpression of Androgen, Oestrogen and Progesterone Receptors in Skin Lesions of Becker’s Naevus
Acta Dermato-Venereologica, 2018 Becker’s naevus is androgen-dependent. The aim of this study was to investigate whether oestrogen and progesterone receptors are involved in this disorder.
Ping Sheng +6 more
doaj +1 more source
Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]
, 2009 Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H. +4 more
core +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT Epimedium (EP) is a traditional Chinese medicine that has been used to treat osteoporosis for several years, but its mechanism of action is unclear. We used ultrahigh‐performance liquid chromatography coupled with triple–quadrupole mass spectrometry (UPLC–QQQ–MS/MS) to detect the components of raw and processed EP samples.
Jinling Liang +8 more
wiley +1 more source
Androgen and estrogen receptor expression in the developing human penis and clitoris. [PDF]
, 2020 To better understand how the human fetal penis and clitoris grows and remodels, we undertook an investigation to define active areas of cellular proliferation and programmed cell death spatially and temporally during development of human fetal external ...
Baskin, Laurence +6 more
core
Bad expression influences time to androgen escape in prostate cancer [PDF]
, 2007 <b>OBJECTIVE</b>: To assess the role of selected downstream Bcl-2 family members (Bad, Bax, Bcl-2 and Bcl-xL) in the development of androgen-independent prostate cancer (AIPC), as androgen-deprivation therapy is the treatment of choice in ...
Bracarda S +9 more
core +1 more source
Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research
ChemBioChem, EarlyView.The “plug‐and‐play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes the commonly used biocompatible reactions and the recent advances of their representative applications in chemical biology research, thus highlighting the
Adam R. Lovato, Zeng Lin, Qingfei Zheng
wiley +1 more source
The "backdoor pathway" of androgen synthesis in human male sexual development. [PDF]
, 2019 Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a
Auchus, Richard J, Miller, Walter L
core +2 more sources
Targeting Cryptochromes in Chronic Diseases
Cell Biology International, EarlyView.ABSTRACT The circadian clock generates 24‐h molecular rhythms through transcription–translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep–wake cycles, body temperature, hormone secretion, metabolism, and immune function.
Takuro Toda, Tsuyoshi Hirota
wiley +1 more source
Chemistry – A European Journal, EarlyView.A facile synthesis of unsymmetrical 1,1’‐disubstituted ferrocene derivatives based on the desymmetrization of 1,1’‐diborylferrocene was developed. Suzuki‐Miyaura cross‐coupling (SMCC) reaction of 1,1’‐diborylferrocene afforded mono‐substituted products without significant loss of the second boryl group, and the subsequent second SMCC reaction afforded ...
Kotaro Ochiai +2 more
wiley +1 more source
Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds
ChemMedChem, EarlyView.Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis +3 more
wiley +1 more source