Results 11 to 20 of about 20,010 (263)
Frontiers in Chemistry, 2022 Prostate cancer is one of the malignant tumors and the second most common malignant tumor in men. Clinically used androgen receptor (AR)–targeted drugs can antagonize androgen and inhibit tumor growth, but these drugs can cause serious resistance ...
Yueheng Qi +5 more
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Synthesis of Hydantoin Androgen Receptor Antagonists and Study on Their Antagonistic Activity
Molecules, 2022 Hydroxymethylthiohydantoin, hydroxymethylthiohydantoin, and hydantoin, containing a pyridine group, were synthesized to study their androgen receptor antagonistic activities. Among them, compounds 6a/6c/7g/19a/19b exhibited excellent androgen receptor antagonistic activity, which was consistent with or even superior to enzalutamide.
Longjun Ma +5 more
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Poultry Science, 2023 The influence of synthetic androgen and estrogenic antagonists (Tamoxifen) on body characteristics and immune response of male and female broilers and the correlation between sex hormone levels were estimated in our experiment.
Mona E.M. Younis +8 more
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Surgical stress delays prostate involution in mice. [PDF]
PLoS ONE, 2013 Androgens control growth of prostate epithelial cells and androgen deprivation induces apoptosis, leading to prostate involution. We investigated the effects of surgical stress on prostate involution induced by androgen ablation and determined the ...
Sazzad Hassan +4 more
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Current Research in Toxicology, 2021 Polychlorinated dibenzofurans (PCDFs) are known to cause endocrine disruption in humans and wildlife but the mechanisms underlying this disruption have not been adequately investigated.
Lukman K. Akinola +3 more
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Prostate International, 2021 Prostate cancer (PCa) is the most common cancer in men. Androgen receptor axis plays a crucial role in the carcinogenesis of PCa. The mainstay treatment of prostate cancer is blockage of androgen receptor axis but in a vast majority of patient resistance
Emre Yekedüz +3 more
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A-Norprogesterone, an Androgen Antagonist
Experimental Biology and Medicine, 1960 SummaryA-norprogesterone antagonizes testosterone induced accessory sex organ hypertrophy in the immature castrate male rat and comb growth stimulation in the chick. Growth of the ventral prostate, seminal vesicles, adrenals and thyroids of intact rats and the chick comb in animals not treated with androgen were significnatly reduced by administration ...
Lerner, L. J., Bianchi, A., Borman, A.
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Response to Androgens and Androgen Receptor Antagonists in the Presence of Cytokines in Prostate Cancer [PDF]
Cancers, 2021 Non-steroidal anti-androgens have a major role in the treatment of non-localized prostate cancer. Interleukins are involved in the regulation of many cellular functions in prostate cancer and also modify cellular response to anti-androgens. A specific role of selected IL is presented in this review.
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Frontiers in Chemistry, 2020 Prostate cancer (PCa), a type of malignancy that arises in the prostate gland, is the most commonly diagnosed neoplasm and the second leading cause of cancer-related deaths in men.
Wenya Han +6 more
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Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19
iScience, 2021 Summary: Epidemiological data showing increased severity and mortality of COVID-19 in men suggests a potential role for androgen in SARS-CoV-2 infection.
Qu Deng +4 more
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