Results 31 to 40 of about 190,106 (204)

Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer [PDF]

, 2001
Objective To examine the role of androgen receptor (AR) gene amplification and aneusomy of the X chromosome in the development of antiandrogen-resistant prostate cancer.
Watters, A.D., Mukherjee, R., Underwood, M.A., Krishna, N.S., Edwards, J., Bartlett, J.M.S.   +5 more
core   +1 more source

A-Norprogesterone, an Androgen Antagonist

Experimental Biology and Medicine, 1960
SummaryA-norprogesterone antagonizes testosterone induced accessory sex organ hypertrophy in the immature castrate male rat and comb growth stimulation in the chick. Growth of the ventral prostate, seminal vesicles, adrenals and thyroids of intact rats and the chick comb in animals not treated with androgen were significnatly reduced by administration ...
Lerner, L. J., Bianchi, A., Borman, A.
openaire   +2 more sources

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: androgen-receptor cofactors and bypass pathways [PDF]

, 2005
Prostate cancer is the second leading cause of cancer related deaths in men from the western world. Treatment of prostate cancer has relied on androgen deprivation therapy for the past 50 years.
J Edwards, Edwards, J., Bartlett, J.M.S., J. M. S. Bartlett   +3 more
core   +1 more source

Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. [PDF]

, 1993
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast ...
Herzinger, Thomas, Blasschke, Dorothea, Hermeking, H., Hörz, W., Herzinger, T., Blaschke, D., Hörz, Wolfram, Wolf, Dieter A., Hermeking, Heiko, Wolf, D.A.   +9 more
core   +1 more source

Virtual Screening and Bioactivity Evaluation of Novel Androgen Receptor Antagonists From Anti-PCa Traditional Chinese Medicine Prescriptions

Frontiers in Chemistry, 2020
Prostate cancer (PCa), a type of malignancy that arises in the prostate gland, is the most commonly diagnosed neoplasm and the second leading cause of cancer-related deaths in men.
Wenya Han, Yuqi Shi, Jie Su, Zhennan Zhao, Xin Wang, Jiazhong Li, Huanxiang Liu   +6 more
doaj   +1 more source

Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19

iScience, 2021
Summary: Epidemiological data showing increased severity and mortality of COVID-19 in men suggests a potential role for androgen in SARS-CoV-2 infection.
Qu Deng, Reyaz ur Rasool, Ronnie M. Russell, Ramakrishnan Natesan, Irfan A. Asangani   +4 more
doaj   +1 more source

The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium [PDF]

, 2008
Progesterone is indispensable for differentiation of human endometrial stromal cells (HESCs) into decidual cells, a process that critically controls embryo implantation.
Cartwright, JE, Yliheikkila, M., Marius C. Jones, Lam, Eric W.-F., Eric W.-F. Lam, Matti Poutanen, Fusi, L, Luca Fusi, Kim, J. J., Ho, K.-K., Teklenburg, G., Kim, JJ, Poutanen, M, Trew, G, Lavery, S., Cartwright, J. E., Judith E. Cartwright, Cloke, B, Kajihara, T, Geoffrey Trew, Takeshi Kajihara, Huhtinen, K., Jones, M. C., Stuart Lavery, Lam, EW, Jan J. Brosens, Huhtinen, K, Lavery, S, J. Julie Kim, Trew, G., Poutanen, M., Kaisa Huhtinen, Kajihara, T., Brosens, Jan J., Cloke, B., Ho, KK, Teklenburg, G, Jones, MC, Brosens, JJ, Yliheikkilä, M, Maria Yliheikkilä, Gijs Teklenburg, Brianna Cloke, Ka-Kei Ho, Fusi, L.   +44 more
core   +1 more source

Transcriptional regulation of prostate kallikrein-like genes by androgen. [PDF]

, 1992
Using gene-specific synthetic oligonucleotides the expression and regulation of kallikrein-like genes in the human prostatic cancer cell line LNCaP were studied.
Schulz, Peter, Fittler, Friedrich, Wolf, Dieter A.   +2 more
core   +1 more source

Endocrine disrupting potential of selected azole and organophosphorus pesticide products through suppressing the dimerization of human androgen receptor in genomic pathway

Ecotoxicology and Environmental Safety, 2022
Several pesticides widely used in agriculture have been considered to be endocrine disrupting chemicals through their binding affinities to estrogen or androgen receptors.
Da-Woon Jung, Da-Hyun Jeong, Hee-Seok Lee   +2 more
doaj   +1 more source

Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis [PDF]

, 2010
Androgens act to stimulate spermatogenesis through androgen receptors (AR) on the Sertoli cells and peritubular myoid cells (PTM). Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source