Results 51 to 60 of about 190,106 (204)

Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen [PDF]

, 2008
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis.
Baker, P.J., Guillou, F., Abel, M.H., Verhoeven, G., De Gendt, K., Guillou, Florian Jean Louis, Charlton, H.M., Monteiro, A., O'Shaughnessy, P.J.   +8 more
core   +1 more source

Effect of small molecules modulating androgen receptor (SARMs) in human prostate cancer models.

PLoS ONE, 2013
The management of hormone-refractory prostate cancer represents a major challenge in the therapy of this tumor, and identification of novel androgen receptor antagonists is needed to render treatment more effective.
Anna Tesei, Carlo Leonetti, Marzia Di Donato, Elisa Gabucci, Manuela Porru, Greta Varchi, Andrea Guerrini, Dino Amadori, Chiara Arienti, Sara Pignatta, Giulia Paganelli, Michele Caraglia, Gabriella Castoria, Wainer Zoli   +13 more
doaj   +1 more source

Clinical, Hormonal and Genetics Features in patients with Androgen Insensitivity Syndrome in Cytogenetic Laboratories in Semarang [PDF]

, 2006
Androgen insensitivity syndrome (AIS) is an X-linked disorder caused by impaired Androgen Receptor (AR) which is encoded in Xq 11-12. In this condition, although the androgen is produced sufficiently, but the peripheral masculinizing effect is blocked ...
Tonang, Alvin
core   +1 more source

In silico comparison between the mutated and wild-type androgen receptors and their influence on the selection of optimum androgenic receptor blockers for the treatment of prostate cancer [version 4; peer review: 2 approved]

F1000Research
Background: Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases.
Hany Akeel Al-Hussaniy, Mohammed J. AL-Zobaidy, Zahraa S. Al-tameemi   +2 more
doaj   +1 more source

Maternal allocation of androgens and antagonistic effects of yolk androgens on sons and daughters [PDF]

Behavioral Ecology, 2005
Mothers can influence the phenotype of their offspring by adjusting the quality of their eggs in relation to sex and reproductive value of the progeny. Maternal androgens in the eggs of vertebrates may mediate such adaptive early maternal effects. However, the evolution of early maternal effects mediated by egg androgens may be constrained by the ...
Saino, Nicola, Ferrari, Rafaella Poala, Romano, Maria, Martinelli, Roberta, Lacroix, André, Gil, Diego, Moller, Anders Pape   +6 more
openaire   +4 more sources

The Effect of Androgen Deprivation Therapy on the Cardiovascular System in Advanced Prostate Cancer

Medicina
Androgen deprivation therapy (ADT) is a mainstay treatment for metastatic prostate cancer, improving progression-free survival. ADT suppresses the production of testosterone and reduces circulating levels of the hormone.
Allison B. Reiss, Samantha Vasalani, Jacqueline Albert, Wendy Drewes, Kathleen Li, Ankita Srivastava, Joshua De Leon, Aaron E. Katz   +7 more
doaj   +1 more source

Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal CA1 Pyramidal Neurons

Frontiers in Cellular Neuroscience, 2019
Neuroactive estrogenic and androgenic steroids influence synaptic transmission, finely modulating synaptic plasticity in several brain regions including the hippocampus.
Alessandro Tozzi, Valentina Durante, Paolo Manca, Michela Di Mauro, Juan Blasi, Silvarosa Grassi, Paolo Calabresi, Suguru Kawato, Suguru Kawato, Vito Enrico Pettorossi   +9 more
doaj   +1 more source

Assessing salivary matrix metalloproteinase‐8 in prostate cancer patients undergoing androgen deprivation therapy

Clinical and Experimental Dental Research, 2022
Introduction Matrix metalloproteinase‐8 (MMP‐8) is considered as one of the most promising diagnostic markers for periodontal disease. Androgen deprivation therapy (ADT) has been correlated with impaired collagen synthesis and an increase in periodontal ...
Maaz A. Memon, Benish Aleem, Hifza A. Memon, Ka Y. Lee   +3 more
doaj   +1 more source

Androgen-induced migration in NIH3T3 mouse fibroblasts: role of AR association with Filamin A. [PDF]

, 2010
Androgen stimulation triggers rapid activation of various signaling effectors in target cells (Migliaccio et al. 2000; Castoria et al. 2003). This occurs through a direct interaction of classical steroid receptors with proto-oncogenic tyrosine kinase ...
Giraldi, Tiziana
core   +1 more source

GLI1 confers profound phenotypic changes upon LNCaP prostrate cancer cells that include the acquisition of a hormone independent state [PDF]

, 2011
The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common tumours is limited.
Nadendla Sandeep K., Thomas, GJ, Ward, M, Lucia S. Bianchi, Hazan Allon, Ghali, Lucy, Matt Ward, Ghali Lucy, Lucia S Bianchi, Thomas, Gareth J., Michael P Philpott, Ghali, L, Philpott Michael P., Sandeep K. Nadendla, Ward Matt, Moutasim, K, Neill, GW, David M Prowse, Thomas Gareth J., Prowse, DM, Sandeep K Nadendla, Philpott, MP, Bianchi, Lucia S., Mahmoud Naase, Harper, LJ, Naase Mahmoud, Hazan, Allon, Moutasim Karwan, Philpott, Michael P., Moutasim, Karwan, Lisa J Harper, Nadendla, Sandeep K., Prowse David M., Gareth J. Thomas, Harper Lisa J., Ward, Matt, Lucy Ghali, Nadendla, SK, Allon Hazan, Hazan, A, Bianchi Lucia S., Gareth J Thomas, Graham W Neill, Karwan Moutasim, David M. Prowse, Naase, Mahmoud, Bianchi, LS, Lisa J. Harper, Prowse, David M., Harper, Lisa J., Graham W. Neill, Naase, M, Neill Graham W., Michael P. Philpott, Neill, Graham W., Bianchi, L., Ghali, L., Harper, L., Hazan, A., Thomas, G., Philpott, M., Moutasim, K., Nadenla, S., Prowse, D., Neill, G., Ward, M., Naase, M.   +66 more
core   +2 more sources