Results 231 to 240 of about 19,533 (266)
Some of the next articles are maybe not open access.
TAS3681: New class of androgen receptor antagonist with androgen receptor downregulating activity.
Journal of Clinical Oncology, 2015266 Background: The persistent activation of the androgen receptor (AR) signaling axis plays a major role in castration-resistant prostate cancer (CRPC). This knowledge has driven the clinical development of new inhibitors of androgen production (e.g., abiraterone) and AR signaling (e.g., enzalutamide).
Kazuhisa Minamiguchi +10 more
openaire +1 more source
Assays to Measure Estrogen and Androgen Agonists and Antagonists
1998Substantial evidence has surfaced on the hormone-like effects of many xenobiotics in fish, wildlife and humans (Colborn et al., 1993). The endocrine and reproductive effects of xenobiotics are believed to be due to their 1) mimicking the effects of endogenous hormones such as estrogens and androgens, 2) antagonizing the effects of normal, endogenous ...
A M, Soto +6 more
openaire +2 more sources
Intermittent Androgen Deprivation Therapy with Antagonist: Really New Information?
European Urology, 2014Intermittent androgen deprivation (IAD) is no longer considered experimental in a selected group of patients [1]. Apart from metastasis situations, there are almost no clear indications for lifelong androgen suppression. As a salvage modality after failed local treatment, androgen suppression lacks clear evidence showing real long-term benefits [2] ,e ...
openaire +2 more sources
Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology, 1975
openaire +2 more sources
openaire +2 more sources
Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.
Cancer research, 1999The role of androgen receptor (AR) mutations in androgen-independent prostate cancer (PCa) was determined by examining AR transcripts and genes from a large series of bone marrow metastases. Mutations were found in 5 of 16 patients who received combined androgen blockade with the AR antagonist flutamide, and these mutant ARs were strongly stimulated by
Taplin, Mary-Ellen +6 more
openaire +2 more sources
Androgen Biosynthesis Inhibitors and Androgen Receptor Antagonists
2004Stephen E. Borst +2 more
openaire +1 more source