Results 231 to 240 of about 20,010 (263)
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An updated review of environmental estrogen and androgen mimics and antagonists
The Journal of Steroid Biochemistry and Molecular Biology, 1998For the last 40 y, substantial evidence has surfaced on the hormone-like effects of environmental chemicals such as pesticides and industrial chemicals in wildlife and humans. The endocrine and reproductive effects of these chemicals are believed to be due to their ability to: (1) mimic the effect of endogenous hormones, (2) antagonize the effect of ...
Sonnenschein, C., Soto, A.M.
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Androgen receptor antagonists: a patent review (2008 – 2011)
Expert Opinion on Therapeutic Patents, 2012Androgen receptor (AR) antagonists are predominantly used as chemical castration to treat prostate cancer (i.e., in conjunction with androgen deprivation therapy (ADT)). Unfortunately, castration-resistant prostate cancer (CRPC) typically develops that is refractory to targeted therapy.
Michael L, Mohler +5 more
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Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.
Cancer research, 1999The role of androgen receptor (AR) mutations in androgen-independent prostate cancer (PCa) was determined by examining AR transcripts and genes from a large series of bone marrow metastases. Mutations were found in 5 of 16 patients who received combined androgen blockade with the AR antagonist flutamide, and these mutant ARs were strongly stimulated by
Taplin, Mary-Ellen +6 more
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Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology, 1975
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Androgen Biosynthesis Inhibitors and Androgen Receptor Antagonists
2004Stephen E. Borst +2 more
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Binary and multi-class classification for androgen receptor agonists, antagonists and binders
Chemosphere, 2021Geven Piir, Sulev Sild, Uko Maran
exaly