Results 41 to 50 of about 41,661 (291)

Upfront docetaxel with androgen deprivation therapy in the elderly patient with metastatic hormone-naïve prostate cancer: Single institution experience [PDF]

, 2018
Upfront docetaxel with androgen deprivation therapy in the elderly patient with metastatic hormone-naïve prostate cancer: Single institution ...
Rea, K, Huckett, R, Rebecca Huckett, Lindsay Jennifer Andrew Rayner, Bahl, A, Katherine Rea, Kabala, J, Eve Blackmore, Blackmore, E, Paul White, Oikonomopoulou, V, Rayner, LJA, Garadi, K, Natasha Wells, Kirk, H, Masson, S, Serena Hilman, Amit Bahl, Susan Masson, Challapalli, A, Krishna Garadi, Viktoria Oikonomopoulou, Hilman, S, Julian Kabala, Wells, N, Amarnath Challapalli, Hannah Kirk, White, P   +27 more
core   +1 more source

Cost-effectiveness analysis of abiraterone, docetaxel or placebo plus androgen deprivation therapy for hormone-sensitive advanced prostate cancer

Einstein (São Paulo)
Objective To evaluate the cost-effectiveness of the addition of chemotherapy or abiraterone to androgen deprivation. Methods We developed an analytical model to determine the cost-effectiveness of the addition of docetaxel or abiraterone versus ...
Pedro Nazareth Aguiar Jr., Pui San Tan, Sarah Simko, Carmelia Maria Noia Barreto, Bárbara de Souza Gutierres, Auro del Giglio, Gilberto de Lima Lopes Jr   +6 more
doaj   +1 more source

Combining Androgen Deprivation and Immunotherapy in Prostate Cancer Treatment: A Mechanistic Approach

Applied Sciences, 2022
Due to its initial dependence on testosterone, prostate cancer patients are initially treated with androgen deprivation therapy, a form of chemical castration. However, in many cases, the cancer develops resistance to this treatment.
Johnna Barnaby, Harsh Vardhan Jain
doaj   +1 more source

Radiation therapy and androgen deprivation in the management of high risk prostate cancer

International Brazilian Journal of Urology, 2011
The combined use of radiation therapy (RT) and androgen deprivation for patients with localized high-risk prostate cancer is commonly accepted as the standard treatment among uro-oncologists.
Alan Dal Pra, Fabio L. Cury, Luis Souhami   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Metformin use and mortality in Asian, diabetic patients with prostate cancer on androgen deprivation therapy: A population-based study [PDF]

, 2023
Background This study aims to examine the associations between metformin use concurrent with androgen deprivation therapy (ADT) and mortality risks in Asian, diabetic patients with prostate cancer (PCa).
Yan Hiu Athena Lee, Kang Liu, Jeremy Man Ho Hui, Pias Tang, Kenrick Ng, Jeffrey Shi Kai Chan, Tse, G., Edward C. Dee   +7 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The role of radiotherapy in localised and locally advanced prostate cancer

Asian Journal of Urology, 2019
For a patient suffering from non-metastatic prostate cancer, the individualized recommendation of radiotherapy has to be the fruit of a multidisciplinary approach in the context of a Tumor Board, to be explained carefully to the patient to obtain his ...
Michel Bolla, Ann Henry, Malcom Mason, Thomas Wiegel   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation

Neoplasia: An International Journal for Oncology Research, 2018
Current treatment strategies provide minimal results for patients with castration-resistant prostate cancer (CRPC). Attempts to target the androgen receptor have shown promise, but resistance ultimately develops, often due to androgen receptor ...
Nicholas E. Brown, Andrew M. Paluch, Madison A. Nashu, Kakajan Komurov, Susan E. Waltz   +4 more
doaj   +1 more source