Results 91 to 100 of about 2,496,118 (309)

Could Testosterone Have a Therapeutic Role in Prostate Cancer?

Urology Journal, 2013
PURPOSE:To discuss the role of membrane androgen receptors and to investigate the potential role of testosterone-albumin conjugate in the prostate cancer (PCa) treatment.MATERIALS AND METHODS: We identified studies published from 1990 onwards by ...
Konstantinos Stamatiou
doaj  

Orchestration of Skin Pathology in Cutaneous Lupus Erythematosus by HLA Class I Down‐Regulated Senescent Epidermal Basal Cells

Arthritis &Rheumatology, EarlyView.
Objective This study investigates the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE). Methods Cellular senescence profiling used datasets from the NCBI GEO database and Accelerating Medicines Partnership (AMP ...
Sena Yamamoto, Yuki Saito, Tsukasa Sato, Seina Nakano, Dain Kasseki, Ayaka Nagao, Norihiro Miura, Kentaro Nagaoka, Arisa Kita, Maki Miyajima, Shogo Ijima, Koji Taniguchi, Atsushi Niida, Takako S. Chikenji   +13 more
wiley   +1 more source

ASC-J9® increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-κB survival signals [PDF]

, 2019
Chi‐Ping Huang, Jinbo Chen, Chi‐Cheng Chen, Guodong Liu, Yong Zhang, Edward M. Messing, Shuyuan Yeh, Chawnshang Chang   +7 more
openalex   +1 more source

The Development of the Human Female Reproductive Tract. Part 1: Uterine Tube and Uterus

Clinical Anatomy, EarlyView.
ABSTRACT The uterine tubes and uterus develop from the paramesonephric (Müllerian) ducts. Most experimental data are obtained in rodents. Since the (micro‐)anatomy of the murine urogenital tract differs from that in humans, evaluation of the translatability of mouse data to human development is relevant.
Cindy J. M. Hülsman, S. Eleonore Köhler, Gabriela Morosan‐Puopolo, Jill P. J. M. Hikspoors, Wouter H. Lamers   +4 more
wiley   +1 more source

Krüppel-like factor 8 is a novel androgen receptor co-activator in human prostate cancer [PDF]

, 2012
Hongjiang He, Xuefeng Gu, Wanhai Xu, Dejun Yang, Xiaomin Wang, Yu‐Chieh Su   +5 more
openalex   +1 more source

PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors

Breast Cancer Research, 2014
IntroductionTriple negative breast cancer (TNBC) is a heterogeneous collection of biologically diverse cancers, which contributes to variable clinical outcomes.
B. Lehmann, Joshua A. Bauer, J. Schafer, Christopher S Pendleton, Luojia Tang, Kimberly C. Johnson, Xi Chen, J. Balko, H. Gómez, C. Arteaga, G. Mills, M. Sanders, J. Pietenpol   +12 more
semanticscholar   +1 more source

The Development of the Human Female Reproductive Tract: Part 2—Vagina

Clinical Anatomy, EarlyView.
ABSTRACT Urogenital epithelium replaces the original paramesonephric (Müllerian) epithelium in the human fetal vagina. We re‐investigated this cell replacement histologically and with three‐dimensional reconstructions. In the lesser pelvis, both Müllerian ducts fuse to form the uterovaginal canal.
Cindy J. M. Hülsman, S. Eleonore Köhler, Gabriela Morosan‐Puopolo, Jill P. J. M. Hikspoors, Wouter H. Lamers   +4 more
wiley   +1 more source

Androgen receptor in relation to progesterone receptor (AR/PR ratio) in non-metastatic hormonal positive, Her2neu negative breast cancer

SVU - International Journal of Medical Sciences
Background: The impact of estrogen/progesterone receptors (ER/PR) is well-established with respect to therapy and prognosis of breast carcinoma. However, the role of androgen receptor (AR) expression is varying among breast cancer subtypes.
Maged A.F. Amine , Ahmed Mubarak Hefni , Shimaa R. Younis*, Tarek M Elsaba , Amen H. Zaky , Ashraf Zedan   +5 more
doaj   +1 more source

OR07-6 Disrupting DNA-binding Domain Dimerization In The Androgen Receptor In Mice Results In a Partial Androgen Insensitivity Model [PDF]

, 2022
Frank Claessens, Claude Libert, Jorma J. Palvimo, Sarah El Kharraz   +3 more
openalex   +1 more source

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source