Results 91 to 100 of about 230,623 (311)

Human androgen deficiency: insights gained from androgen receptor knockout mouse models

Asian Journal of Andrology, 2014
The mechanism of androgen action is complex. Recently, significant advances have been made into our understanding of how androgens act via the androgen receptor (AR) through the use of genetically modified mouse models.
Kesha Rana, Rachel A Davey, Jeffrey D Zajac   +2 more
doaj   +1 more source

Modulation of the cytosolic androgen receptor in striated muscle by sex steroids [PDF]

The influence of orchiectomy (GDX) and steroid administration on the level of the cytosolic androgen receptor in the rat levator ani muscle and in rat skeletal muscles (tibialis anterior and extensor digitorum longus) was studied.
Max, S. E., Rance, N. E.
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Supplementary Figure 4 from Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer [PDF]

, 2023
Maria Thadani‐Mulero, Luigi Portella, Shihua Sun, Matthew Sung, Alexandre Matov, Robert L. Vessella, Eva Corey, David M. Nanus, Stephen R. Plymate, Paraskevi Giannakakou   +9 more
openalex   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Androgens and Hypertension in Men and Women: a Unifying View. [PDF]

, 2017
This review was designed to revaluate the androgen role on the mechanisms of hypertension and cardiovascular risks in both men and women. Sex steroids are involved in the regulation of blood pressure, but pathophysiological mechanism is not well ...
Carmina, E. 4., Gnessi, Lucio, Lanzolla, Giulia, Moretti, Costanzo, Moretti, Marta   +4 more
core   +1 more source

Functional mapping of androgen receptor enhancer activity [PDF]

, 2020
Chia-Chi Flora Huang, Shreyas Lingadahalli, Tunc Morova, Doğancan Özturan, Eugene Hu, Ivan Pak Lok Yu, Simon Linder, Marlous Hoogstraat, Suzan Stelloo, Funda Sar, Henk G. van der Poel, Umut Berkay Altıntaş, Mohammadali Saffarzadeh, Stéphane Le Bihan, Brian McConeghy, Bengul Gokbayrak, Felix Y. Feng, Martin Gleave, Andries M. Bergman, Colin C. Collins, Faraz Hach, Wilbert Zwart, Eldon Emberly, Nathan A. Lack   +23 more
openalex   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

Androgen regulation of the androgen receptor coregulators

BMC Cancer, 2008
Background The critical role of the androgen receptor (AR) in the development of prostate cancer is well recognized. The transcriptional activity of AR is partly regulated by coregulatory proteins. It has been suggested that these coregulators could also
Helenius Merja A, Suikki Hanna E, Waltering Kati K, Urbanucci Alfonso, Visakorpi Tapio   +4 more
doaj   +1 more source

Phosphorylation of the androgen receptor in a human prostate tumor cell line [PDF]

, 1991
The aim of the study described in this thesis was to deterntine whether the androgen receptor is a phosphoprotein, resembling in this respect the other members of the steroid/vitamin D /thyroid hormone receptor fantily.
Laar, J.H. (Jacoba) van
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