Results 91 to 100 of about 204,414 (356)

Phosphorylation of the androgen receptor is associated with reduced survival in hormonerefractory prostate cancer patients [PDF]

, 2008
Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostate cancer (HRPC) and can result in phosphorylation of the androgen receptor (AR).
C Le Page, D Ruggero, DA Altomare, G Ayala, GJ Bubley, H Murillo, HK Lin, HK Lin, J Edwards, J Edwards, J M S Bartlett, JA Fraser, JQ Cheng, KS McCarty Jr, L Cleeve, L K Gemmell, L Yang, M Manin, N Gao, N Pommery, P McCall, PK Majumder, PM Ghosh, R Mukherjee, SN Malik, T Kirkegaard, YD Liao   +26 more
core   +2 more sources

Human androgen deficiency: insights gained from androgen receptor knockout mouse models

Asian Journal of Andrology, 2014
The mechanism of androgen action is complex. Recently, significant advances have been made into our understanding of how androgens act via the androgen receptor (AR) through the use of genetically modified mouse models.
Kesha Rana, Rachel A Davey, Jeffrey D Zajac   +2 more
doaj   +1 more source

Dual Photoredox/Cu‐Catalysis Enables Diastereoselective Synthesis of 3‐β‐Ethynyltropanes via Decarboxylative Alkynylation

Advanced Synthesis &Catalysis, EarlyView.
A copper‐catalyzed decarboxylative alkynylation of tropanes is developed. This approach works under mild conditions and selectively produces a range of 3‐β‐alkynylated tropanes. Moreover, it provides a versatile and convergent platform for further functionalization of the triple bond.
Mayssa Zayene, Franck Le Bideau, Pascal Retailleau, Hichem Ben Jannet, Vincent Gandon, Anis Romdhane, Samir Messaoudi   +6 more
wiley   +1 more source

Transcriptional regulation of prostate kallikrein-like genes by androgen. [PDF]

, 1992
Using gene-specific synthetic oligonucleotides the expression and regulation of kallikrein-like genes in the human prostatic cancer cell line LNCaP were studied.
Fittler, Friedrich, Schulz, Peter, Wolf, Dieter A.   +2 more
core   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer. [PDF]

, 2018
Protein homeostasis (proteostasis) is a potential mechanism that contributes to cancer cell survival and drug resistance. Constitutively active androgen receptor (AR) variants confer anti-androgen resistance in advanced prostate cancer. However, the role
Armstrong, Cameron M, Chen, Hong-Wu, Dall'Era, Marc, Evans, Christopher P, Gao, Allen C, Liu, Chengfei, Liu, Liangren, Lombard, Alan P, Lou, Wei, Noel, Onika DV, Tepper, Clifford G, Yang, Joy C, Zhao, Ruining   +12 more
core   +2 more sources

Asymmetric Intramolecular α‐Arylation of Polar Amino Acids Bearing β‐Leaving Groups

Angewandte Chemie, EarlyView.
Use of enolate chemistry to functionalise amino acids with β‐heteroatom side‐chains (serine, cysteine, threonine, etc.) is hampered by β‐elimination. We show that α‐arylation can be achieved by incorporating the side chain into a saturated heterocycle, making the unwanted elimination a disfavoured 5‐endo‐trig reaction.
Ömer Taspinar, Daniel J. Leonard, Nathan Picois, Cornelia Göcke, Matej Žabka, Hazel A. Sparkes, Jonathan Clayden   +6 more
wiley   +2 more sources

Transient Interdomain Interactions Modulate the Monomeric Structural Ensemble and Self‐Assembly of Huntingtin Exon 1

Advanced Science, EarlyView.
Polyglutamine (polyQ) tract expansion (≥ 36 amino acids) within the N‐terminal region of the Huntingtin protein (Httex1) causes Huntington's disease (HD), for which the underlying causes are not well‐understood. The authors performed computer simulations to understand the cause of HD at the molecular level.
Priyesh Mohanty, Tien Minh Phan, Jeetain Mittal   +2 more
wiley   +1 more source

Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer [PDF]

, 2001
Objective To examine the role of androgen receptor (AR) gene amplification and aneusomy of the X chromosome in the development of antiandrogen-resistant prostate cancer.
Bartlett, J.M.S., Edwards, J., Krishna, N.S., Mukherjee, R., Underwood, M.A., Watters, A.D.   +5 more
core   +1 more source

In silico prediction of nuclear receptor binding to polychlorinated dibenzofurans and its implication on endocrine disruption in humans and wildlife

Current Research in Toxicology, 2021
Polychlorinated dibenzofurans (PCDFs) are known to cause endocrine disruption in humans and wildlife but the mechanisms underlying this disruption have not been adequately investigated.
Lukman K. Akinola, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi   +3 more
doaj