Results 71 to 80 of about 140,287 (313)

When fat goes down, prostate cancer is on the ropes

Molecular & Cellular Oncology, 2019
Reprogrammed lipid metabolism and persistent androgen receptor signaling commonly mark aggressive prostate cancer. We describe that targeting de-novo lipogenesis deprives prostate cancer cells of substrates and fuel, while inhibiting androgen receptor ...
Giorgia Zadra, Massimo Loda
doaj   +1 more source

Matrix Stiffness Directs Stemness Signatures in Breast Cancer

Advanced Healthcare Materials, EarlyView.
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky, Elvis Pandzic, Sean Porazinski, J Justin Gooding, Kristopher A Kilian   +4 more
wiley   +1 more source

Molecular Modeling Studies of Natural Inhibitors of Androgen Signaling in Prostate Cancer

Cancer Informatics, 2022
Prostate cancer is the second most common disease in men and the sixth leading cause of death from cancer globally, with 20 million men expected to be affected by 2024 thus considered as chronic illness which requires immediate attention.
Samuel O Olubode, Mutolib O Bankole, Precious A Akinnusi, Olayinka S Adanlawo, Kehinde I Ojubola, Daniel O Nwankwo, Onome E Edjebah, Ayomide O Adebesin, Abigail O Ayodele   +8 more
doaj   +1 more source

Androgen receptor epigenetics.

Translational andrology and urology, 2013
The androgen receptor (AR) is a transcription factor that drives the differentiation of prostate epithelium by regulating the expression of several hundred genes. Conversely, AR also plays a central role in prostate cancer (PCa) development, and it continues to be active in tumors that relapse after castration (castration-resistant prostate cancer ...
Cai, Changmeng, Yuan, Xin, Balk, Steven P.   +2 more
openaire   +2 more sources

The Androgen Receptor in Breast Cancer

Frontiers in Endocrinology, 2018
Breast cancer (BC) is a hormone-related tumor. Despite the progress in BC therapy, this disease still remains the most common cancer amongst women around the world. This is likely due to the amazing BC heterogeneity. Accumulating evidence suggests a role for androgen signaling in BC.
Giovannelli, Pia, Di Donato, Marzia, Galasso, Giovanni, Di Zazzo, Erika, Bilancio, Antonio, Migliaccio, Antimo   +5 more
openaire   +4 more sources

Androgen action via testicular arteriole smooth muscle cells is important for leydig cell function, vasomotion and testicular fluid dynamics [PDF]

, 2010
Regulation of blood flow through the testicular microvasculature by vasomotion is thought to be important for normal testis function as it regulates interstitial fluid (IF) dynamics which is an important intra-testicular transport medium.
Bergh, A., Sigrid Kilter, Richard M. Sharpe, Philippa T K Saunders, Lindsey Moffat, Sharpe, R.M., Welsh Michelle, Welsh, M., Anders Bergh, Philippa T. K. Saunders, Atanassova Nina, Saunders Philippa T. K., Atanassova, N., Smith, Lee B., Richard M Sharpe, Bergh, Anders, Bergh, Anders,, Kilter Sigrid, Sharpe, Richard M, Michelle Welsh, Sharpe Richard M., Moffat Lindsey, Lee B. Smith, Sharpe, Richard M., Moffat, Lindsey, Smith, L.B., Lee B Smith, Saunders, P.T.K., Kilter, Sigrid, Bergh Anders, Saunders, Philippa T. K.; id_orcid, Welsh, Michelle, Saunders, Philippa TK, Nina Atanassova, Smith Lee B., Smith, Lee B, Moffat, L., Kilter, S., Kilter, Sigrid,, Atanassova, Nina   +39 more
core   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer

European Journal of Breast Health, 2014
Objective: To detect the relationship between molecular subtypes of breast cancer with expressions of androgen receptor, cytokeratin 5/6 (CK5/6)and Ki-67.Materials and Methods: Expressions of androgen receptor, CK5/6 and Ki67 were determined by ...
Münire Kayahan, Ufuk Oguz İdiz, Zuhal Gucin, Fazilet Erozgen, Naim Memmi, Mahmut Müslümanoğlu   +5 more
doaj   +1 more source

Up-Regulation of Hepatic Alpha-2-HS-Glycoprotein Transcription by Testosterone via Androgen Receptor Activation

Cellular Physiology and Biochemistry, 2014
Background/Aims: Fetuin-A (alpha-2-HS-glycoprotein, AHSG), a liver borne plasma protein, contributes to the prevention of soft tissue calcification, modulates inflammation, reduces insulin sensitivity and fosters weight gain following high fat diet or ...
Jakob Voelkl, Tatsiana Pakladok, Yun Lin, Robert Viereck, Aleksandra Lebedeva, Damaris Kukuk, Bernd J. Pichler, Ioana Alesutan, Florian Lang   +8 more
doaj   +1 more source

Disruption of androgen metabolism, regulation and effects : involvement of steroidogenic enzymes [PDF]

, 2014
Communication between organs and tissues is predominately controlled by hormones. Hormones regulate a vast variety of physiological and behavioural activities, including metabolism, growth and development, reproduction, sleep and mood.
Fürstenberger, Cornelia
core   +1 more source