Results 91 to 100 of about 1,391,256 (255)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development [PDF]

, 2010
Peer ...
Richard M. Sharpe, Philippa T K Saunders, Sergio R. Batlouni, Batlouni, Sergio R., Luiz R França, Esnal, Arantza; id_orcid, Batlouni, Sergio R. [UNESP], Karel De Gendt, Arantza Esnal, Esnal Arantza, Verhoeven Guido, Batlouni, Sergio R, De Gendt Karel, Philippa T. K. Saunders, Johannes V Swinnen, Swinnen, Johannes V., Saunders Philippa T. K., Johannes V. Swinnen, Sergio R Batlouni, Saunders, Philippa T K; id_orcid, França Luiz R., Richard M Sharpe, França, Luiz R, Saunders, Philippa T. K., Saunders, Philippa T.K., Sharpe, Richard M, Luiz R. França, Guido Verhoeven, Sharpe Richard M., Saunders, Philippa T K, Ariane Willems, Sharpe, Richard M., Batlouni Sergio R., Swinnen, Johannes V, Swinnen Johannes V., Willems, Ariane, Esnal, Arantza, Verhoeven, Guido, De Gendt, Karel, Swinnen, Johan, Franca, Luiz R., Willems Ariane   +41 more
core   +1 more source

Androgen receptor in relation to progesterone receptor (AR/PR ratio) in non-metastatic hormonal positive, Her2neu negative breast cancer

SVU - International Journal of Medical Sciences
Background: The impact of estrogen/progesterone receptors (ER/PR) is well-established with respect to therapy and prognosis of breast carcinoma. However, the role of androgen receptor (AR) expression is varying among breast cancer subtypes.
Maged A.F. Amine , Ahmed Mubarak Hefni , Shimaa R. Younis*, Tarek M Elsaba , Amen H. Zaky , Ashraf Zedan   +5 more
doaj   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

GLI1 confers profound phenotypic changes upon LNCaP prostrate cancer cells that include the acquisition of a hormone independent state [PDF]

, 2011
The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common tumours is limited.
Nadendla Sandeep K., Thomas, GJ, Ward, M, Lucia S. Bianchi, Hazan Allon, Ghali, Lucy, Matt Ward, Ghali Lucy, Lucia S Bianchi, Thomas, Gareth J., Michael P Philpott, Ghali, L, Philpott Michael P., Sandeep K. Nadendla, Ward Matt, Moutasim, K, Neill, GW, David M Prowse, Thomas Gareth J., Prowse, DM, Sandeep K Nadendla, Philpott, MP, Bianchi, Lucia S., Mahmoud Naase, Harper, LJ, Naase Mahmoud, Hazan, Allon, Moutasim Karwan, Philpott, Michael P., Moutasim, Karwan, Lisa J Harper, Nadendla, Sandeep K., Prowse David M., Gareth J. Thomas, Harper Lisa J., Ward, Matt, Lucy Ghali, Nadendla, SK, Allon Hazan, Hazan, A, Bianchi Lucia S., Gareth J Thomas, Graham W Neill, Karwan Moutasim, David M. Prowse, Naase, Mahmoud, Bianchi, LS, Lisa J. Harper, Prowse, David M., Harper, Lisa J., Graham W. Neill, Naase, M, Neill Graham W., Michael P. Philpott, Neill, Graham W., Bianchi, L., Ghali, L., Harper, L., Hazan, A., Thomas, G., Philpott, M., Moutasim, K., Nadenla, S., Prowse, D., Neill, G., Ward, M., Naase, M.   +66 more
core   +2 more sources

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Regulation of androgen receptor function in neurons.

, 2023
reservedAndrogen receptor (AR) is a transcription factor playing a crucial role in the acquisition of the male phenotype. AR localizes to the cytosol and upon androgen binding it dimerizes, translocates to the nucleus, and binds to specific DNA sequences
HEGAZY, ADHAM KAMALELDEEN OMARA
core  

Role of the androgen receptor in melanoma aggressiveness

Cell Death and Disease
Malignant melanoma represents the fifth most common cancer in the world and its incidence is rising. Novel therapies targeting receptor tyrosine kinases, kinases and immune checkpoints have been employed with a significant improvement of the overall ...
Marzia Di Donato, Costanza Maria Cristiani, Mariaelena Capone, Cinzia Garofalo, Gabriele Madonna, Lucia Carmela Passacatini, Margaret Ottaviano, Paolo Antonio Ascierto, Ferdinando Auricchio, Ennio Carbone, Antimo Migliaccio, Gabriella Castoria   +11 more
doaj   +1 more source

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

Advanced Science, EarlyView.
The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo, Wei Zhuang, Zean Li, Yiming Lai, Yongyi Ou, Dongquan Li, Shanhe Huang, Tianlong Luo, Jintao Hu, Bingliang Chen, Jianhan Fu, Tao Zhuo, Hankun Jiang, Yin Lu, Hai Huang, Kewei Xu, Shengmeng Peng, Qing Yuan   +17 more
wiley   +1 more source

In silico comparison between the mutated and wild-type androgen receptors and their influence on the selection of optimum androgenic receptor blockers for the treatment of prostate cancer [version 4; peer review: 2 approved]

F1000Research
Background: Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases.
Hany Akeel Al-Hussaniy, Mohammed J. AL-Zobaidy, Zahraa S. Al-tameemi   +2 more
doaj   +1 more source