Results 91 to 100 of about 140,287 (313)

GLI1 confers profound phenotypic changes upon LNCaP prostrate cancer cells that include the acquisition of a hormone independent state [PDF]

, 2011
The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common tumours is limited.
Nadendla Sandeep K., Thomas, GJ, Ward, M, Lucia S. Bianchi, Hazan Allon, Ghali, Lucy, Matt Ward, Ghali Lucy, Lucia S Bianchi, Thomas, Gareth J., Michael P Philpott, Ghali, L, Philpott Michael P., Sandeep K. Nadendla, Ward Matt, Moutasim, K, Neill, GW, David M Prowse, Thomas Gareth J., Prowse, DM, Sandeep K Nadendla, Philpott, MP, Bianchi, Lucia S., Mahmoud Naase, Harper, LJ, Naase Mahmoud, Hazan, Allon, Moutasim Karwan, Philpott, Michael P., Moutasim, Karwan, Lisa J Harper, Nadendla, Sandeep K., Prowse David M., Gareth J. Thomas, Harper Lisa J., Ward, Matt, Lucy Ghali, Nadendla, SK, Allon Hazan, Hazan, A, Bianchi Lucia S., Gareth J Thomas, Graham W Neill, Karwan Moutasim, David M. Prowse, Naase, Mahmoud, Bianchi, LS, Lisa J. Harper, Prowse, David M., Harper, Lisa J., Graham W. Neill, Naase, M, Neill Graham W., Michael P. Philpott, Neill, Graham W.   +54 more
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ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Regulation of androgen receptor function in neurons.

, 2023
reservedAndrogen receptor (AR) is a transcription factor playing a crucial role in the acquisition of the male phenotype. AR localizes to the cytosol and upon androgen binding it dimerizes, translocates to the nucleus, and binds to specific DNA sequences
HEGAZY, ADHAM KAMALELDEEN OMARA
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Artificial Intelligence‐Based Body Composition Analysis Reveals Sex‐Specific Prognostic Markers and Their Clinical Value in Gastric Cancer: A Multicenter Study

Advanced Science, EarlyView.
This study applied AI to quantify multidimensional body composition from CT images in gastric cancer and healthy controls. Distinct sex‐specific patterns and disease‐related alterations were identified and were associated with survival. Higher muscle and fat measures were linked to improved outcomes.
Tianxiang Li, Tingting Liu, Qian Yang, Zhiqing Zhang, Xiaofang Guo, Xiang Wang, Yihan Zhang, Limin Ge, Yu Su, Wenjun Wu, Weihua Guo, Zheng Wang, Lian Yang, Yanfeng Niu   +13 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival

, 2023
IntroductionBreast cancer in older women tends to have more favourable biology, compared to younger women. Androgen receptor (AR) is significant for breast tumour carcinogenesis; however, the role of AR in older women has not been fully explored ...
Kalvala, Jahnavi, Kwok-Leung Cheung, Andrew R. Green, Abdi, Jamal, Green, Andrew R., Ruth M. Parks, Jamal Abdi, Parks, Ruth M., Jahnavi Kalvala, Cheung, Kwok Leung   +9 more
core   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Androgen-induced migration in NIH3T3 mouse fibroblasts: role of AR association with Filamin A.

, 2010
Androgen stimulation triggers rapid activation of various signaling effectors in target cells (Migliaccio et al. 2000; Castoria et al. 2003). This occurs through a direct interaction of classical steroid receptors with proto-oncogenic tyrosine kinase ...
Giraldi, Tiziana
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