Results 111 to 120 of about 231,777 (344)

Could Testosterone Have a Therapeutic Role in Prostate Cancer?

Urology Journal, 2013
PURPOSE:To discuss the role of membrane androgen receptors and to investigate the potential role of testosterone-albumin conjugate in the prostate cancer (PCa) treatment.MATERIALS AND METHODS: We identified studies published from 1990 onwards by ...
Konstantinos Stamatiou
doaj  

Phosphorylation of the androgen receptor in a human prostate tumor cell line [PDF]

, 1991
The aim of the study described in this thesis was to deterntine whether the androgen receptor is a phosphoprotein, resembling in this respect the other members of the steroid/vitamin D /thyroid hormone receptor fantily.
Laar, J.H. (Jacoba) van
core  

The Voice of Cantú: Lower Voice Pitch Is a New Phenotypic Feature of Cantú Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cantú syndrome (CS) is a rare genetic condition caused by pathogenic variants in either ABCC9 or KCNJ8, leading to gain‐of‐function of KATP‐channels. The main clinical features are hypertrichosis and cardiovascular abnormalities. This study investigates the voice characteristics in individuals with CS, an aspect that has received little ...
Lotte Kleinendorst, Melanie N. S. Molegraaf, Dorothy K. Grange, Rico N. P. M. Rinkel, Mieke M. van Haelst   +4 more
wiley   +1 more source

Androgen and estrogen receptor expression in the developing human penis and clitoris. [PDF]

, 2020
To better understand how the human fetal penis and clitoris grows and remodels, we undertook an investigation to define active areas of cellular proliferation and programmed cell death spatially and temporally during development of human fetal external ...
Baskin, Laurence, Cao, Mei, Cunha, Gerald R, Isaacson, Dylan, Li, Yi, Overland, Maya, Sinclair, Adriane   +6 more
core  

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Down, But Not Out: Partial Elimination of Androgen Receptors in the Male Mouse Brain Does Not Affect Androgenic Regulation of Anxiety or HPA Activity [PDF]

, 2015
Chieh V. Chen, Jennifer L. Brummet, Cynthia L. Jordan, S. Marc Breedlove   +3 more
openalex   +1 more source

GLI3 and androgen receptor are mutually dependent for their malignancy-promoting activity in ovarian and breast cancer cells

, 2022
Min Lin, Haiyan Zhu, Qi Shen, Lu‐Zhe Sun, Xueqiong Zhu   +4 more
openalex   +1 more source

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

Annals of Neurology, EarlyView.
Objectives Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear. Here, we examined mediation through differential DNA methylation (DNAm) to better understand possible ...
Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams   +37 more
wiley   +1 more source

Androgen receptor in relation to progesterone receptor (AR/PR ratio) in non-metastatic hormonal positive, Her2neu negative breast cancer

SVU - International Journal of Medical Sciences
Background: The impact of estrogen/progesterone receptors (ER/PR) is well-established with respect to therapy and prognosis of breast carcinoma. However, the role of androgen receptor (AR) expression is varying among breast cancer subtypes.
Maged A.F. Amine , Ahmed Mubarak Hefni , Shimaa R. Younis*, Tarek M Elsaba , Amen H. Zaky , Ashraf Zedan   +5 more
doaj   +1 more source

Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]

, 2003
Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Bartlett, J.M.S., Edwards, J., Krishnan, S., Witton, C.J.   +3 more
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