Results 111 to 120 of about 2,496,118 (309)

High‐Affinity Peptide‐Drug Conjugate Ligands for the TRIM24 PHD and Bromodomain

Chemistry – A European Journal, EarlyView.
We report a series of bivalent peptide‐drug conjugate (PDC) ligands for tripartite motif‐containing protein 24 (TRIM24). These ligands simultaneously engage the PHD and BRD of TRIM24 through an intramolecular (in cis) binding mode, resulting in high affinity binding.
Michael A. Platt, Ekaterina Kot, Louise A. W. Martin, Antoine L. D. Wallabrègue, Liwen Song, Alistair M. Boyd, Lizbé Koekemoer, Ester M. Hammond, Stuart J. Conway   +8 more
wiley   +1 more source

Dual Biological Potential: Anticancer and Antibacterial Activities of Bis‐α, ω‐Bifunctional Sphingolipids from the Marine Sponge Oceanapia ramsayi

ChemMedChem, EarlyView.
Preparative work on Oceanapia ramsayi sponge specimens collected from the northeast South African coast (A) result in the isolation of four bifunctional sphingolipids (center). Bioassays of these compounds and their derivatives (B) show antimicrobial activity against bacterial pathogens and selective cytotoxicity to breast cancer tissue culture cell ...
Dele Abdissa Keneni, Idris Njanje, Jarmo‐Charles Julian Kalinski, Michelle Isaacs, Tarryn Swart, Candace Davison, Jo‐Anne de la Mare, Rosemary Ann Dorrington   +7 more
wiley   +1 more source

Abnormal Mammary Gland Development and Growth Retardation in Female Mice and MCF7 Breast Cancer Cells Lacking Androgen Receptor [PDF]

, 2003
Shuyuan Yeh, Yueh‐Chiang Hu, Peng‐Hui Wang, Chao Xie, Qingquan Xu, Meng‐Yin Tsai, Zhihong Dong, Ruey-Sheng Wang, Ting‐Hein Lee, Chawnshang Chang   +9 more
openalex   +1 more source

Profiling Inhibitor Scaffolds for the Cancer Target Jumonji‐C Domain‐Containing Protein 6

ChemMedChem, EarlyView.
High‐throughput mass spectrometry assays identify scaffolds for the development of inhibitors of the anticancer target Jumonji‐C domain‐containing protein 6 (JMJD6). Molecular docking studies suggest strategies for structure‐guided inhibitor optimization.
Thomas P. Corner, Eidarus Salah, Anthony Tumber, James P. Holt‐Martyn, Lennart Brewitz, Christopher J. Schofield   +5 more
wiley   +1 more source

Modulation of Androgen Receptor Transcriptional Activity by the Estrogen Receptor [PDF]

, 1994
M. Vijay Kumar, Mark E. Leo, Donald J. Tindall   +2 more
openalex   +1 more source

Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting [PDF]

, 2022
Mithila Sawant, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Jingqin Luo, Vandna Kukshal, Joseph M. Jez, Myung Sik Jeon, Bo Zhang, Tiandao Li, Bin Fang, Yunting Luo, Nicholas J. Lawrence, Harshani R. Lawrence, Felix Y. Feng, Nupam P. Mahajan   +15 more
openalex   +1 more source

Pleural Metastasis From Male Breast Cancer: A Case Report

Diagnostic Cytopathology, EarlyView.
ABSTRACT Male breast cancer (MBC) is a rare disease accounting for less than 1% of breast cancers and for 0.11% of all male malignancies. Despite the fact that the epidemiologic, clinical, and therapeutic literature regarding female breast cancer is well documented, little is known about the features of male breast cancer.
Patrizia Straccia, Esther Diana Rossi
wiley   +1 more source

Prevalence of AAS‐Positive Samples at Drug Abuse Laboratory Sweden Between 2014 and 2023 and Sub‐Study of Dual Use of AAS and Narcotics

Drug Testing and Analysis, EarlyView.
Throughout 2014–2023, over 20,000 AAS analyses have been conducted at the drug of abuse laboratory, Karolinska University Hospital. Approximately 20% and 2% of the samples have been positive for AAS, with no trends of increase or decrease. Around 50% of the AAS‐positive samples were also positive for narcotics (year 2022–2023), with gender differences;
Kim Petterson Bohlin, Tomas Villén, Oscar Hopcraft, Anton Pohanka, Lena Ekström   +4 more
wiley   +1 more source

A Novel, Essential Control for Clonality Analysis with Human Androgen Receptor Gene Polymerase Chain Reaction [PDF]

, 2002
Jeroen P. van Dijk, Leonie H.H. Heuver, Bert A. van der Reijden, Reinier Raymakers, Théo de Witte, Joop H. Jansen   +5 more
openalex   +1 more source

Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 2. A New Minor Metabolite With Antagonistic Activity on the Androgen Receptor Can Indicate Recent Substance Intake

Drug Testing and Analysis, EarlyView.
A novel early excreted minor metabolite of LGD‐4033 was detected and coded as M8. Its presence was evaluated as an indicator of recent substance intake versus end‐tail findings. Additionally, the agonist/antagonist properties of M8 and other selected LGD‐4033 metabolites on the androgen receptor (AR) were studied using in silico molecular docking and ...
Yiannis S. Angelis, Panagiotis Sakellariou, Annekathrin M. Keiler, Mario Thevis, Andreas Thomas, Kevin Lam, Gerhard Wolber, Ariadni Vonaparti, Sven Voss, Michael Petrou, Emmanuel N. Pitsinos   +10 more
wiley   +1 more source