Results 121 to 130 of about 196,475 (280)

Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer

Nature Communications, 2016
Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity.
Christine Henzler, Yingming Li, Rendong Yang, Terri McBride, Yeung Ho, Cynthia Sprenger, Gang Liu, Ilsa Coleman, Bryce Lakely, Rui Li, Shihong Ma, Sean R. Landman, Vipin Kumar, Tae Hyun Hwang, Ganesh V. Raj, Celestia S. Higano, Colm Morrissey, Peter S. Nelson, Stephen R. Plymate, Scott M. Dehm   +19 more
doaj   +1 more source

Accuracy of direct gradient sensing by cell-surface receptors [PDF]

arXiv, 2009
Chemotactic cells of eukaryotic organisms are able to accurately sense shallow chemical concentration gradients using cell-surface receptors. This sensing ability is remarkable as cells must be able to spatially resolve small fractional differences in the numbers of particles randomly arriving at cell-surface receptors by diffusion.
arxiv  

Follicle-Stimulating Hormone and Androgens Increase the Concentration of the Androgen Receptor in Sertoli Cells* [PDF]

, 1988
Guido Verhoeven, Jean Ćailleau
openalex   +1 more source

Androgen receptor dysfunction in human androgen insensitivity

Trends in Endocrinology & Metabolism, 1995
The androgen insensitivity syndromes comprise a spectrum of phenotypic abnormalities in male sex differentiation and development that result from target tissue resistance to androgen action due to molecular lesions in the X-chromosome-linked androgen receptor gene.
openaire   +3 more sources

Correlation between the presence of the nuclear AR-V7 androgen receptor and clinical evolution of prostate cancer: in vitro analysis of a combination of compounds targeting PI3K [PDF]

, 2019
Introduzione: PCa è una malattia multiforme e biologicamente molto eterogenea. Diversi meccanismi chiave nella progressione della malattia da androgeno-dipendente ad androgeno-indipendente (CRCP) possono essere attribuiti ad alterazione nella via di ...
Cattarino, Susanna
core  

Androgen and estrogen receptors in hepatocellular carcinoma and in the surrounding noncancerous liver tissue [PDF]

, 1986
S. Tsuyoshi Ohnishi, Tohru Murakami, Takashi Moriyama, Keiji Mitamura, Michio Imawari   +4 more
openalex   +1 more source

Chemical sensing by cell-surface chemoreceptor arrays: the roles of receptor cooperativity and adaptation [PDF]

arXiv, 2012
Most sensory cells use cross-membrane chemoreceptors to detect chemical signals in the environment. The biochemical properties and spatial organization of chemoreceptors play important roles in achieving and maintaining sensitivity and accuracy of chemical sensing.
arxiv  

Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway

Frontiers in Pharmacology
BackgroundPulmonary arterial hypertension (PAH) exhibits significant gender differences in prognosis, with male patients typically showing worse outcomes than females.
Jiayan Sun, Jiayan Sun, Jiayan Sun, Jiancheng Lin, Jiancheng Lin, Jiancheng Lin, Di Yin, Di Yin, Di Yin, Zetao Pan, Zetao Pan, Zetao Pan, Yuheng Ye, Yuheng Ye, Yuheng Ye, Yi Wang, Yi Wang, Yi Wang, Xiaowan Wang, Xiaowan Wang, Xiaowan Wang, Qiang Guo, Qiang Guo, Qiang Guo, Qiang Guo   +24 more
doaj   +1 more source

Androgen receptor levels in cranial nerve nuclei and tongue muscles in rats [PDF]

, 1986
WH Yu, MY McGinnis
openalex   +1 more source

Androgen receptors in the diabetic rat [PDF]

, 1980
Marta Tesone, Ricardo Martins Oliveira-Filho, Luiz Biella de Souza Valle, Juan Carlos Calvo, J. Lino Barañao, V. G. Foglia, Eduardo H. Charreau   +6 more
openalex   +1 more source