Results 231 to 240 of about 196,475 (280)

The androgen receptor

2023
The Androgen Receptor (AR) is a ligand (androgen) activated transcription factor and a member of the nuclear receptor (NR) superfamily. It is required for male sex hormone function. AR-FL (full-length) has the domain structure of NRs, an N-terminal domain (NTD) required for transactivation, a DNA-binding domain (DBD), a nuclear localization signal (NLS)
Greg, Van-Duyne, Ian A, Blair, Cynthia, Sprenger, Vera, Moiseenkova-Bell, Stephen, Plymate, Trevor M, Penning   +5 more
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The androgen receptor in spermatogenesis

Cytogenetic and Genome Research, 2003
Androgens are steroid hormones that are necessary for normal male phenotype expression, including the outward development of secondary sex characteristics as well as the initiation and maintenance of spermatogenesis. Many physiological actions of androgens are mediated by the androgen receptor (AR), a member of the nuclear receptor superfamily.
Hsu Hy, Chawnshang Chang, Shuyuan Yeh, Han-Jung Lee, Chen Yt, Chang M, Loretta L. Collins   +6 more
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The androgen receptor mRNA

BioEssays, 2004
AbstractAndrogens (testosterone), acting via the androgen receptor (AR) a nuclear transcription factor, regulate male sexual development and body composition. In addition, AR expression plays an important role in the proliferation of human prostate cancer and confers a better prognosis in breast cancer. AR mRNA stability is central to the regulation of
Jackie A. Wilce, Bu B. Yeap, Peter J. Leedman   +2 more
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Androgens, Antiandrogens and Androgen Receptor Abnormalities

European Urology, 1996
Information on the molecular structure of the human androgen receptor has increased insight into the molecular mechanism of action of androgens and antiandrogens. It has also facilitated the study of molecular defects in the androgen receptor gene associated with prostate cancer.
A O Brinkmann, C W Kuil
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Androgens and androgen receptors in breast cancer

The Journal of Steroid Biochemistry and Molecular Biology, 2007
Aromatase (CYP19) converts adrenal and ovarian androgens into estrogens, which supports the growth of estrogen-dependent breast cancers. Anti-aromatase agents are displacing antiestrogens as the first-line treatment for estrogen receptor positive breast cancers.
Juan C. Díaz-Chico, Ana González, A. Cabrera de León, Domingo Navarro, B. Nicolás Díaz-Chico, Ricardo Chirino, Raquel Ramírez, F. Germán Rodríguez, A. Aguirre Jaime, Cristina Bilbao   +9 more
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Testosterone and the Androgen Receptor

Urologic Clinics of North America, 2022
Testosterone is a steroid hormone that is responsible for the development of normal male sexual characteristics and function as well as the maintenance of homeostasis among multiple organ systems throughout life. Testosterone production is regulated by the hypothalamic-pituitary axis under the direction of gonadotropin-releasing hormone and luteinizing
Thomas, Gerald, Ganesh, Raj
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Targeting the Androgen Receptor

Urologic Clinics of North America, 2012
Androgen receptor (AR)-mediated signaling is critical to the growth and survival of prostate cancer. Although medical castration and antiandrogen therapy can decrease AR activity and lower PSA, castration resistance eventually develops. Recent work exploring the molecular structure and evolution of AR in response to hormonal therapies has revealed ...
Terence W. Friedlander, Charles J. Ryan
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Androgen Receptor: An Overview

Critical Reviews™ in Eukaryotic Gene Expression, 1995
The action of androgens in regulating development and growth is mediated by androgen receptor (AR). AR is a member of the steroid hormone receptor superfamily, a class of receptors that function through their ability to regulate the transcription of specific genes.
Alan Saltzman, Chihuei Wang, Atsushi Mizokami, Shuyuan Yeh, Win-Jing Young, Chawnshang Chang, Evan T. Keller, Han-Jung Lee   +7 more
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Androgen receptors and their biology

2001
Publisher Summary The androgen receptor plays an important role in development and differentiated function in both health and disease. Advances in molecular biology have significantly impacted our knowledge of the role of this important member of the steroid receptor superfamily throughout the body. The chapter discusses that androgens freely diffuse
Nancy L. Weigel, Marco Marcelli, Dolores J. Lamb   +2 more
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