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Androgen receptor expression and immune characteristics of HER2-low metastatic triple-negative breast cancer. [PDF]

NPJ Breast Cancer
Tarantino P, Cha J, Binboga Kurt B, Chu X, Jovanović B, Zhou A, Hughes M, Russo D, DiLullo M, Wrabel E, Jeselsohn R, Lin NU, Carter J, Chen YS, Li T, Tayob N, Mittendorf EA, Schnitt SJ, Goel S, Tolaney SM.   +19 more
europepmc   +1 more source

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The androgen receptor

2023
The Androgen Receptor (AR) is a ligand (androgen) activated transcription factor and a member of the nuclear receptor (NR) superfamily. It is required for male sex hormone function. AR-FL (full-length) has the domain structure of NRs, an N-terminal domain (NTD) required for transactivation, a DNA-binding domain (DBD), a nuclear localization signal (NLS)
Greg, Van-Duyne, Ian A, Blair, Cynthia, Sprenger, Vera, Moiseenkova-Bell, Stephen, Plymate, Trevor M, Penning   +5 more
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Testosterone and the Androgen Receptor

Urologic Clinics of North America, 2022
Testosterone is a steroid hormone that is responsible for the development of normal male sexual characteristics and function as well as the maintenance of homeostasis among multiple organ systems throughout life. Testosterone production is regulated by the hypothalamic-pituitary axis under the direction of gonadotropin-releasing hormone and luteinizing
Thomas, Gerald, Ganesh, Raj
openaire   +2 more sources

Androgens and androgen receptors in breast cancer

The Journal of Steroid Biochemistry and Molecular Biology, 2007
Aromatase (CYP19) converts adrenal and ovarian androgens into estrogens, which supports the growth of estrogen-dependent breast cancers. Anti-aromatase agents are displacing antiestrogens as the first-line treatment for estrogen receptor positive breast cancers.
B, Nicolás Díaz-Chico, F, Germán Rodríguez, Ana, González, Raquel, Ramírez, Cristina, Bilbao, A, Cabrera de León, A, Aguirre Jaime, Ricardo, Chirino, Domingo, Navarro, Juan C, Díaz-Chico   +9 more
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Androgens, Antiandrogens and Androgen Receptor Abnormalities

European Urology, 1996
Information on the molecular structure of the human androgen receptor has increased insight into the molecular mechanism of action of androgens and antiandrogens. It has also facilitated the study of molecular defects in the androgen receptor gene associated with prostate cancer.
C W, Kuil, A O, Brinkmann
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The androgen receptor mRNA

BioEssays, 2004
AbstractAndrogens (testosterone), acting via the androgen receptor (AR) a nuclear transcription factor, regulate male sexual development and body composition. In addition, AR expression plays an important role in the proliferation of human prostate cancer and confers a better prognosis in breast cancer. AR mRNA stability is central to the regulation of
Bu B, Yeap, Jackie A, Wilce, Peter J, Leedman   +2 more
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The androgen receptor in spermatogenesis

Cytogenetic and Genome Research, 2003
Androgens are steroid hormones that are necessary for normal male phenotype expression, including the outward development of secondary sex characteristics as well as the initiation and maintenance of spermatogenesis. Many physiological actions of androgens are mediated by the androgen receptor (AR), a member of the nuclear receptor superfamily.
L L, Collins, H-J, Lee, Y-T, Chen, M, Chang, H-Y, Hsu, S, Yeh, C, Chang   +6 more
openaire   +2 more sources