Results 271 to 280 of about 140,287 (313)
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Androgen Receptor: An Overview
Critical Reviews in Eukaryotic Gene Expression, 1995The action of androgens in regulating development and growth is mediated by androgen receptor (AR). AR is a member of the steroid hormone receptor superfamily, a class of receptors that function through their ability to regulate the transcription of specific genes.
C, Chang +7 more
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Targeting the Androgen Receptor
Urologic Clinics of North America, 2012Androgen receptor (AR)-mediated signaling is critical to the growth and survival of prostate cancer. Although medical castration and antiandrogen therapy can decrease AR activity and lower PSA, castration resistance eventually develops. Recent work exploring the molecular structure and evolution of AR in response to hormonal therapies has revealed ...
Terence W, Friedlander, Charles J, Ryan
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Androgen receptor mutations and androgen insensitivity
Molecular and Cellular Endocrinology, 2002The androgen receptor (AR) is a high affinity receptor protein encoded on the human X-chromosome that mediates the actions of androgens during development and in the adult. Defects in this receptor protein result in a wide range of abnormalities of male sexual development.
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Androgen receptors and their biology
2001Publisher Summary The androgen receptor plays an important role in development and differentiated function in both health and disease. Advances in molecular biology have significantly impacted our knowledge of the role of this important member of the steroid receptor superfamily throughout the body. The chapter discusses that androgens freely diffuse
D J, Lamb, N L, Weigel, M, Marcelli
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The Androgen Receptor: An Overview
1994Publisher Summary This chapter provides an overview of the androgen receptor (AR). AR is a ligand-activated transcriptional regulatory protein that mediates androgen-induced male sexual development and function. The chapter presents a schematic diagram that highlights the major functional domains of human AR.
Z X, Zhou +3 more
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2019
Androgens and the androgen receptor (AR) play crucial roles in the biology of normal and diseased prostate tissue, including prostate cancer (PCa). This dependence is evidenced by the use of androgen depletion therapy (ADT) as the primary treatment for locally advanced, metastatic, or relapsed PCa.
Aashi P, Chaturvedi, Scott M, Dehm
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Androgens and the androgen receptor (AR) play crucial roles in the biology of normal and diseased prostate tissue, including prostate cancer (PCa). This dependence is evidenced by the use of androgen depletion therapy (ADT) as the primary treatment for locally advanced, metastatic, or relapsed PCa.
Aashi P, Chaturvedi, Scott M, Dehm
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Androgen receptor polymorphism (CAG repeats) and androgenicity
Clinical Endocrinology, 2005SummaryObjective Polymorphism of the androgen receptor (AR) has been related to various pathophysiological conditions, such as osteoporosis and infertility. The objectives of this study were to evaluate the frequency of distribution in a normal Italian population and to assess CAG repeats (CAGr) in other conditions, such as hypoandrogenism ...
CANALE D +6 more
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Androgens and androgen receptor in prostate and ovarian malignancies
Frontiers in Bioscience, 2003The molecular and biochemical mechanisms contributing to the development and progression of both prostate and ovarian carcinogenesis are currently unknown. A better understanding of the cross-talk between endocrine, signal transduction and regulatory pathways in normal and neoplastic prostatic and ovarian tissues is necessary to elucidate malignant ...
Katie L, Meehan, Marianne D, Sadar
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Androgen dependency of the androgen receptor in rat epididymis
Biochemical and Biophysical Research Communications, 1975Abstract Binding of radioactive androgen to the 8S epididymal receptor is reduced to undetectable levels after 30 days of castration. Testosterone propionate(200 μg/day)administered starting immediately after castration and continued for 30 days prevented the disappearance of binding activity.
R S, Calandra +3 more
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Androgens and Androgen Receptor in Dermatology
2002In addition to male sexual development and maturation, androgens also mediate sebum secretion and hair growth. The effect of androgens is mainly through their binding to the androgen receptor (AR) which is a nuclear receptor superfamily member. These androgen-AR complexes then enhance their target genes’ expression by binding to response elements in ...
Uno Hideo +17 more
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