Results 91 to 100 of about 18,995 (290)
Journal of Neuroinflammation, 2020 Background Tibolone is a synthetic steroid used in clinical practice for the treatment of climacteric symptoms and osteoporosis. Active metabolites of tibolone, generated in target tissues, have an affinity for estrogen and androgen receptors. Astrocytes
Andrea Crespo-Castrillo +2 more
doaj +1 more source
Classification and Virtual Screening of Androgen Receptor Antagonists
, 2016 Computational tools, such as quantitative structure−activity relationship (QSAR), are highly useful as screening support for prioritization of substances of very high concern (SVHC).
Jiazhong Li (418532) +1 more
core +1 more source
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies
Advanced Science, EarlyView.In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang +4 more
wiley +1 more source
Androgen receptor dynamics in prostate cancer: from disease progression to treatment resistance
Frontiers in OncologyProstate cancer is the most common cancer among men worldwide, especially in those over 65, and is a leading cause of cancer-related mortality. The disease typically advances from an androgen-dependent state to castration-resistant prostate cancer (CRPC),
Caihong Li, Dongkai Cheng, Peng Li
doaj +1 more source
Androgen Receptor Antagonists Suppress Immunotherapy in Prostate Cancer [PDF]
Cancer Discovery, 2016 Abstract Surgical castration synergizes with immunotherapy, but chemical castration has suppressive effects.
openaire +2 more sources
CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN
Advanced Science, EarlyView.ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu +13 more
wiley +1 more source
Advanced Science, EarlyView.Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu +20 more
wiley +1 more source
Theca Cell INSL3 and Steroids Together Orchestrate the Growing Bovine Antral Follicle
Frontiers in Physiology, 2017 Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione.
Yanzhenzi Dai +4 more
doaj +1 more source
Engineered antibody and neuropeptide mediated radionuclide targeting in prostate cancer
, 2010 PhDProstate cancer (PC) is the most common cancer type in men in the western world and to date no definitive stratergy to image PC is avaliable. This thesis explores the possibility of using Prostate Specific Membrane Antigen (PSMA) and Gastrin Releasing
Kashani, Roxana M G +1 more
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