Virtual Screening and Bioactivity Evaluation of Novel Androgen Receptor Antagonists From Anti-PCa Traditional Chinese Medicine Prescriptions [PDF]
Frontiers in Chemistry, 2020 Prostate cancer (PCa), a type of malignancy that arises in the prostate gland, is the most commonly diagnosed neoplasm and the second leading cause of cancer-related deaths in men.
Wenya Han +6 more
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Second generation androgen receptor antagonists and challenges in prostate cancer treatment [PDF]
Cell Death and Disease, 2022 Prostate cancer is a hormone-dependent malignancy, whose onset and progression are closely related to the activity of the androgen receptor (AR) signaling pathway.
Yanhua Chen +4 more
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Synthesis of Hydantoin Androgen Receptor Antagonists and Study on Their Antagonistic Activity [PDF]
Molecules, 2022 Hydroxymethylthiohydantoin, hydroxymethylthiohydantoin, and hydantoin, containing a pyridine group, were synthesized to study their androgen receptor antagonistic activities.
Longjun Ma +5 more
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Identifying androgen receptor antagonists using a metabolically competent high-throughput screening assay [PDF]
Current Research in ToxicologyAndrogen receptor (AR) is a nuclear receptor with a well-established role in sexual function and development. Modifications in AR can lead to endocrine disruption, cancer, and other diseases, making it imperative to identify compounds that influence ...
Caitlin Lynch +5 more
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Discovery and Identification of Pyrazolopyramidine Analogs as Novel Potent Androgen Receptor Antagonists [PDF]
Frontiers in Pharmacology, 2018 Androgen receptor (AR), an important target in the current androgen derivation therapy, plays a critical role in the development and progress of prostate cancer (PCa).
Lingyan Wang +3 more
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Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists [PDF]
eLife, 2018 Pathways modulating glucose homeostasis independently of insulin would open new avenues to combat insulin resistance and diabetes. Here, we report the establishment, characterization, and use of a vertebrate ‘insulin-free’ model to identify insulin ...
Sri Teja Mullapudi +10 more
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Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists. [PDF]
PLoS ONE, 2015 The androgen receptor (AR) surface-directed antagonist MJC13 inhibits AR function and proliferation of prostate cancer (PC) cells. These effects are related to arrest of an AR/chaperone complex in the cytoplasm.
Ji Ho Suh +5 more
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The protein composition of exosomes released by prostate cancer cells is distinctly regulated by androgen receptor-antagonists and -agonist to stimulate growth of target cells [PDF]
Cell Communication and SignalingBackground Prostate cancer (PCa) is a prevalent malignancy in men worldwide, ranking as the second leading cause of cancer-related death in Western countries. Various PCa hormone therapies, such as androgen receptor (AR)-antagonists or supraphysiological
Golnaz Atri Roozbahani +4 more
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Cells, 2020 Prostate cancer is the most commonly diagnosed malignancy in men. Its growth mainly relies on the activity of the androgen receptor (AR), justifying the use of androgen deprivation therapy as a gold standard treatment for the metastatic disease ...
Hadjer Dellal +8 more
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Frontiers in Chemistry, 2022 Prostate cancer is one of the malignant tumors and the second most common malignant tumor in men. Clinically used androgen receptor (AR)–targeted drugs can antagonize androgen and inhibit tumor growth, but these drugs can cause serious resistance ...
Yueheng Qi +5 more
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