Results 61 to 70 of about 18,995 (290)

Progress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer

Drug Design, Development and Therapy, 2021
Yi-Fu Liu, Sheng-Qiang Fu, Yu-Chang Yan, Bin-Bin Gong, Wen-Jie Xie, Xiao-Rong Yang, Ting Sun, Ming Ma Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, Jiangxi Province, People’s Republic of ...
Liu YF, Fu SQ, Yan YC, Gong BB, Xie WJ, Yang XR, Sun T, Ma M   +7 more
doaj  

Phosphorylation/Dephosphorylation of Androgen Receptor as a Determinant of Androgen Agonistic or Antagonistic Activity

Biochemical and Biophysical Research Communications, 1999
Protein phosphorylation/dephosphorylation is an important posttranslational modification that plays a critical role in signal transduction. The androgen receptor (AR) is under such control. We demonstrate that androgen receptor phosphorylation determines whether or not AR ligands perform as agonists or antagonists in LNCaP cells.
L G, Wang, X M, Liu, W, Kreis, D R, Budman   +3 more
openaire   +2 more sources

Discovery of deshydroxy bicalutamide derivatives as androgen receptor antagonists [PDF]

European Journal of Medicinal Chemistry, 2019
Deshydroxy propioanilides were synthesised by Michael addition reaction between substituted thiophenols onto four different phenylacrylamide derivatives to give twenty-three novel deshydroxy bicalutamide derivatives lacking the central hydroxyl group. The antiproliferative activities of these compounds were evaluated against human prostate cancer cell ...
Sahar Kandil, Kok Yung Lee, Laurie Davies, Sebastiano A. Rizzo, D. Alwyn Dart, Andrew D. Westwell   +5 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Enhancement of androgen receptor expression induced by (R)-methanandamide in prostate LNCaP cells [PDF]

, 2003
It has been recently shown that cannabinoids may regulate the growth of many cell types. In the present work we examined the effect of the anandamide analogue (R)-methanandamide (MET) on androgen-dependent prostate LNCaP cell growth. We found that 0.1 μM
Sánchez, Ana M, Ana M Sánchez, Ruiz-Llorente, Lidia, Lidia Ruiz-Llorente, Dı́az-Laviada, Inés, Marı́a G Sánchez, Inés Dı́az-Laviada, Sánchez, Marı́a G   +7 more
core   +2 more sources

Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists

, 2016
An aryloxy tetramethylcyclobutane was identified as a novel template for androgen receptor (AR) antagonists via cell-based high-throughput screening. Follow-up to the initial “hit” established 5 as a viable lead.
Jon Engebretsen (2148376), Javier Gonzalez (2025346), Samantha Greasley (2134057), Patrick Johnson (2148397), Martin Edwards (126755), Amina Zoubeidi (2148382), Wenyue Hu (799025), Paul Richardson (48962), Hiroaki Matsimoto (2148370), Chuangxing Guo (2148394), Toby Underwood (2148403), Andrew Morell (2148409), Hidetoshi Kuruma (2148379), Manli Shi (2148400), Robert Felstead (2148412), Martin Gleave (146446), Angelica Linton (2148373), Martha Ornelas (2148421), Gerrit Los (2148391), Hovik Gukasyan (2148418), Ping Kang (300222), Benjamin J. Burke (1309443), David Briere (2148415), Susan Kephart (2128099), Natilie Hosea (2148388), Asako Nagata (2128075), Mason Pairish (2039902), Andrea N. Fanjul (2148406), Kevin Dack (2148385)   +28 more
core   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Development of Androgen Receptor Antagonists with Promising Activity in Castration-Resistant Prostate Cancer

, 2009
Androgen receptor (AR) continues to play a central role in prostate cancers that relapse after androgen deprivation therapy, but these tumors are refractory to available AR antagonists. In a recent issue of Science, Tran et al.
Shen, Howard C., Balk, Steven P.
core   +1 more source

AR, the Cell Cycle, and Prostate Cancer [PDF]

, 2011
The androgen receptor (AR) is a critical effector of prostate cancer development and progression. The dependence of this tumor type on AR activity is exploited in treatment of disseminated prostate cancers, wherein ablation of AR function (achieved ...
Balk, Steven, Knudsen, Karen E.
core   +1 more source