Results 91 to 100 of about 124,766 (300)
Basic & Clinical Cancer Research, 2016 Background: Androgen receptors (AR) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. Current drugs cannot inhibit the activity of these receptors very well.
Samad Muhammadnejad +6 more
doaj
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Apocrine glands in the eyelid of primates contribute to the ocular host defense [PDF]
, 2004 Apocrine glands of Moll are regular components of primate eyelids. We studied the distribution and localization of these glands in three different primate species, the common marmoset, the rhesus monkey, and the hamadryas baboon.
Stoeckelhuber, B. M. +2 more
core +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
A study of androgen and estrogen receptors α, β in skin tags
Indian Journal of Dermatology, 2010 Background: In women, the age of 50 is suggested to be the turning point of life at which the development of skin tags comes to a stop. A major event that occurs around this period of life is menopause/andropause.
El Safoury Omar +2 more
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Thyroxine-binding globulin: investigation of microheterogeneity [PDF]
, 1981 Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland +4 more
core +1 more source
Advanced Science, EarlyView.Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke +14 more
wiley +1 more source
Correlation between the number of breast duct cells expressing androgen, estrogen and progesterone receptors and the size of the changed tissue in patients with gynecomastia [PDF]
Medicinski Podmladak, 2023 Introduction: Gynecomastia is an abnormal growth of the male breast due to excessive proliferation of ductal epithelial cells. It usually occurs during puberty, so the influence of hormones on the stimulation of ductal cells is indicative.
Mladenović Danilo +2 more
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Advanced Science, EarlyView.Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo +20 more
wiley +1 more source
Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis
International Journal of Endocrinology, 2015 The liver is one of the most essential organs involved in the regulation of energy homeostasis. Hepatic steatosis, a major manifestation of metabolic syndrome, is associated with imbalance between lipid formation and breakdown, glucose production and ...
Minqian Shen, Haifei Shi
doaj +1 more source