Results 111 to 120 of about 176,817 (345)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

A National Analysis of Temporal Changes in Prescribing of Testosterone Replacement Therapy Considering Methods of Delivery and Government Regulation

The World Journal of Men's Health, 2021
Purpose: Testosterone replacement therapy (TRT) is commonly used for various causes of androgen deficiency and subsidized by the Pharmaceutical Benefits Scheme (PBS) in Australia when appropriate.
Andrew Morton, Michael Williams, Marlon Perera, Sachinka Ranasinghe, Patrick E. Teloken, Marissa Williams, Eric Chung, Matthew J. Roberts   +7 more
doaj   +1 more source

Estradiol and testosterone levels in patients undergoing partial hepatectomy - A possible signal for hepatic regeneration? [PDF]

, 1989
In five adult male patients undergoing a 40-60% partial hepatectomy, serum sex hormone levels before and after hepatic resection were determined. Blood was drawn immediately prior to each surgical procedure and at specified time points postoperatively ...
A Francavilla, A Francavilla, A Francavilla, A Francavilla, B Fisher, B Saint Aubert, C Majumdar, CS Song, DH Marshall, FL Moolten, HL Leffert, I Seidman, IF Turocy, J Menard, J Simck, J Simck, JA Caruana, JC Davis, JH Laragh, K Sakuma, KH Raab, LE Porter, MJ Duffy, NLR Bucher, NLR Bucher, P Bannister, P Vic, PK Eagon, PK Eagon, PL Corvol, RA Richman, RF Aten, S Bengmark, S Bengmark, W Powell-Jones   +34 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Unlocking the Continuous Flow Asymmetric Hydrogenation of Olefins Through the Development of a Non‐Deactivating Immobilized Iridium Catalyst

Angewandte Chemie, EarlyView.
We have developed stable, robust, and reusable heterogeneous metal catalysts for an efficient continuous flow asymmetric hydrogenation (AH) of a variety of olefins, far beyond the typical benchmark AH. The products are produced continuously over long periods of time with high catalytic performance (up to 99% ee).
Jorge Faiges, Nicola Zanda, Patricia Llanes, Miquel A. Pericàs, Oscar Pàmies, Montserrat Diéguez   +5 more
wiley   +2 more sources

Psychiatric characterization of children with genetic causes of hyperandrogenism [PDF]

, 2010
Objective: Very little is known about the mental health status in children with genetic causes of hyperandrogenism. This study sought to characterize psychiatric morbidity in this group. Design/methods: Children (8-18 years) with the diagnosis of classic
Ernst, Monique, Green-Golan, Liza, Leschek, Ellen, Merke, Deborah, Müller, Sven, Ng, Pamela, Sinaii, Ninet, VanRyzin, Carol   +7 more
core   +2 more sources

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Rodent Models of Polycystic Ovary Syndrome [PDF]

, 2013
Rodents are clearly valuable models for assessing disruption of fertility. The effects of different steroid treatments at different stages of reproductive life through from fetal to adult have been assessed for effects on fertility, ovarian morphology ...
Duncan, Colin, McNeilly, Alan S
core   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

Androgens and Female Sexuality: Molecular Insights, Neuroendocrine Crosstalk and Future Therapeutic Directions [PDF]

, 2023
Giulia Montan, Massimo Carollo, Luciano Ruiz Torres, Giovanni Buzzaccarini, Andrea Giannini, Andrea Etrusco, Erich Cosmi, Marcello Rigano, Vito Chiàntera, Antonio Simone Laganà, Gaspare Cucinella, Giuseppe Gullo   +11 more
openalex   +1 more source