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Androgens, Antiandrogens and Androgen Receptor Abnormalities
European Urology, 1996Information on the molecular structure of the human androgen receptor has increased insight into the molecular mechanism of action of androgens and antiandrogens. It has also facilitated the study of molecular defects in the androgen receptor gene associated with prostate cancer.
C W, Kuil, A O, Brinkmann
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Androgen antagonists in androgen target tissues
Pharmacology & Therapeutics, 1984Most antiandrogens appear to act by binding to the androgen receptor and competitively inhibiting the binding of testosterone and cihydrotestosterone to the receptor. Focusing on those compounds which appear to inhibit androgen receptor mediated responses this review discusses the chemistry of those antiandrogens which have been studied to the extent ...
D J, Tindall +3 more
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2014
Androgens are important for male sex development and physiology. Their actions are mediated by the androgen receptor (AR), a ligand-dependent nuclear transcription factor. The activity of the AR is controlled at multiple stages due to ligand binding and induced structural changes assisted by the foldosome, compartmentalization, recruitment of ...
Ralf, Werner, Paul-Martin, Holterhus
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Androgens are important for male sex development and physiology. Their actions are mediated by the androgen receptor (AR), a ligand-dependent nuclear transcription factor. The activity of the AR is controlled at multiple stages due to ligand binding and induced structural changes assisted by the foldosome, compartmentalization, recruitment of ...
Ralf, Werner, Paul-Martin, Holterhus
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Androgens, Anabolic-Androgenic Steroids, and Inhibitors
American Journal of Therapeutics, 2000Androgens are steroid hormones responsible for male sexual characteristics, testosterone being the principal androgen secreted by the testes. Androgens have both masculinizing and growth-stimulating or anabolic effects. Synthetic analogs of androgens have been used by professional, as well as amateur, athletes for possible performance enhancement.
J L, Donahue, D T, Lowenthal
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Androgen Insensitivity Syndrome
Seminars in Reproductive Medicine, 2012The androgen insensitivity syndromes (AIS) fall within the generic category of 46,XY DSD (disorder of sex development) and present as phenotypes associated with complete or partial resistance to the action of androgens. Three categories are recognized: complete androgen insensitivity syndrome (CAIS), partial androgen insensitivity syndrome (PAIS), mild
Hughes, Ieuan +3 more
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Androgen insensitivity syndrome: Gonadal androgen receptor activity
American Journal of Obstetrics and Gynecology, 1984To determine whether abnormalities of the androgen receptor previously observed in skin fibroblasts from patients with androgen insensitivity syndrome also occur in the gonads of affected individuals, androgen receptor activity in the gonads of a patient with testicular feminization syndrome was investigated.
C B, Coulam, M L, Graham, T C, Spelsberg
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Androgens and androgen receptors in breast cancer
The Journal of Steroid Biochemistry and Molecular Biology, 2007Aromatase (CYP19) converts adrenal and ovarian androgens into estrogens, which supports the growth of estrogen-dependent breast cancers. Anti-aromatase agents are displacing antiestrogens as the first-line treatment for estrogen receptor positive breast cancers.
B, Nicolás Díaz-Chico +9 more
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Androgen receptor polymorphism (CAG repeats) and androgenicity
Clinical Endocrinology, 2005SummaryObjective Polymorphism of the androgen receptor (AR) has been related to various pathophysiological conditions, such as osteoporosis and infertility. The objectives of this study were to evaluate the frequency of distribution in a normal Italian population and to assess CAG repeats (CAGr) in other conditions, such as hypoandrogenism ...
CANALE D +6 more
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2007
Androgens are essential for the development and maintenance of male sexual characteristics. They exert their effects through the androgen receptor, which is a member of the …
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Androgens are essential for the development and maintenance of male sexual characteristics. They exert their effects through the androgen receptor, which is a member of the …
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Androgen receptor mutations and androgen insensitivity
Molecular and Cellular Endocrinology, 2002The androgen receptor (AR) is a high affinity receptor protein encoded on the human X-chromosome that mediates the actions of androgens during development and in the adult. Defects in this receptor protein result in a wide range of abnormalities of male sexual development.
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