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Biosynthesis of andrographolide in Andrographis paniculata
Phytochemistry, 2010Andrographolide, a diterpene lactone, is isolated from Andrographis paniculata which is well known for its medicinal properties. The biosynthetic route to andrographolide was studied using [1-(13)C]acetate, [2-(13)C]acetate and [1,6-(13)C(2)]glucose. The peak enrichment of eight carbon atoms in the (13)C NMR spectra of andrographolide suggested that ...
Nishi, Srivastava, Anand, Akhila
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Chemical Transformation of Andrographolide.
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Mahesh Pal +2 more
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Andrographolide as a potent and promising antiviral agent
Chinese Journal of Natural Medicines, 2020Andrographolide is a labdane diterpenoid extracted and purified from the aerial parts of plants belonging to genus Andrographis (Acanthaceae). The research has shown the plant based compound is low cytotoxic, having antimicrobial, anti-cancer, antiviral and anti-parasitic effects.
Reshi, Latif, Chi-Yong, Wang
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Flavonoids and Andrographolides from Andrographis paniculata.
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Y, Koteswara Rao +3 more
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Andrographolide: Synthetic Methods and Biological Activities
Mini-Reviews in Medicinal Chemistry, 2020Andrographolide, a labdane diterpenoid, is extracted and isolated from the plants of Andrographis paniculata. Andrographolide and its derivatives exhibited a wide range of biological properties, including anticancer activity, antibacterial activity, hepatoprotective activity, antiinflammatory activity, antiviral activity, antimalarial activity ...
Meng Hao, Min Lv, Hui Xu
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Safety Evaluation of Andrographolide-nanosuspensions
Indian Journal of Animal Research, 2021Background: Andrographolide (ANDRO) is a hydrophobic drug, which faces the problem of limited absorption due to poor water solubility. The current research prepared andrographolide nanosuspensions (ANDRO-NS) and examined in vivo toxicity for mice. Methods: ANDRO-NS were prepared by anti-solvent precipitation method, transmission electron micrographs ...
Haigang Wu +5 more
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Potential anti-angiogenic sulfates of andrographolide
Journal of Asian Natural Products Research, 2013A new regioisomer of andrographolide, 17-hydro-9-dehydro-andrographolide (1), and five new sulfates of andrographolide (2-6) were isolated from Xiyanping, a China licensed anti-inflammatory drug derived from andrographolide through sulfation reaction. Their chemical structures were elucidated by spectroscopic and chemical methods.
Xiao-Wu, Xiao +3 more
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Andrographolides – An Overview
The genus <i>Andrographis</i> is usually bitter and is the source of several diterpenoids, of which water-soluble labdane diterpenoid is andrographolide. Among the various diterpene lactones reported from most of the species of <i>Andrographis</i>, andrographolide is considered one of the major bioactive secondary metabolites ...S. Karuppusamy +2 more
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The genotoxicity and cytotoxicity assessments of andrographolide in vitro
Food and Chemical Toxicology, 2012Andrographolide is a major phytoconstituent present in Andrographis paniculata, a plant used in traditional medicines in Asia for various ailments. This tropical shrub was reported to possess various pharmacological activities and has been marketed around the world including Europe, however the toxicological data especially potential genotoxicity ...
Yusrizam, Sharifuddin +2 more
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Preparation and evaluation of andrographolide-loaded microemulsion
Journal of Microencapsulation, 2012Andrographolide has a low aqueous solubility and oral bioavailability, which limits its clinical application. Reform the dosage forms of andrographolide to improve its aqueous solubility and oral bioavailability. The formulation, characterisation, stability, anti-inflammatory effect, pharmacokinetics and oral toxicity of andrographolide-loaded ...
Hong, Du +9 more
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