Results 41 to 50 of about 1,570 (204)

Influence of body odors and gender on perceived genital arousal [PDF]

, 2018
Olfaction is often linked to mating behavior in nonhumans. Additionally, studies in mating behavior have shown that women seem to be more affected by odor cues than men. However, the relationship between odor cues and sexual response—specifically, sexual
Alho, L., Alves-Oliveira, P., Carvalho, J., Ferreira, J., Nobre, P., Olsson, M. J., Soares, S. C.   +6 more
core   +1 more source

Coumarin‐Based Aldo‐Keto Reductase Family 1C (AKR1C) 2 and 3 Inhibitors

ChemMedChem, Volume 19, Issue 21, November 4, 2024.
The AKR1C family of enzymes are overexpressed in numerous cancers where they are involved in drug resistance development. Coumarin amide 3 a possessed IC50 values of 50 nM and 90 nM for AKR1C3 and AKR1C2, respectively, and exhibits ‘drug‐like’ metabolic stability and half‐life in human and mouse liver microsomes and plasma.
Sravan K. Jonnalagadda, Ling Duan, Louise F. Dow, Geetha P Boligala, Elizabeth Kosmacek, Kristyn McCoy, Rebecca Oberley‐Deegan, Yashpal Singh Chhonker, Darryl J. Murry, C. Patrick Reynolds, Barry J. Maurer, Trevor M. Penning, Paul C. Trippier   +12 more
wiley   +1 more source

Improving the production of 22‐hydroxy‐23,24‐bisnorchol‐4‐ene‐3‐one in Mycolicibacterium smegmatis

Microbial Biotechnology, Volume 17, Issue 8, August 2024.
Currently, one of the challenge of the steroid industry is to achieve the production of C22 intermediates, such as 22‐hydroxy‐23,24‐bisnorchol‐4‐ene‐3‐one (4‐HBC), from phytosterols by metabolic engineering avoiding the presence of by‐products contamination. C22 steroids are used for the synthesis of progesterone in the pharma industry.
Gabriel Hernández‐Fernández, Miguel G. Acedos, Isabel de la Torre, Juan Ibero, José L. García, Beatriz Galán   +5 more
wiley   +1 more source

Halo‐1,2,3‐triazoles: Valuable Compounds to Access Biologically Relevant Molecules

ChemBioChem, Volume 25, Issue 10, May 17, 2024.
1,4,5‐trisubstituted halo‐1,2,3‐triazoles are emerging scaffolds with a wide range of applications in the Life Science. In this review, we explore the synthesis, the functionalization, and the applications of halo‐triazole derivatives in biologically relevant molecules including nucleosides, carbohydrates, peptides and proteins. Abstract 1,2,3‐triazole
Dylan Coelho, Yoann Colas, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud, Laura Iannazzo   +4 more
wiley   +1 more source

The Smell of Age: Perception and Discrimination of Body Odors of Different Ages [PDF]

, 2012
Our natural body odor goes through several stages of age-dependent changes in chemical composition as we grow older. Similar changes have been reported for several animal species and are thought to facilitate age discrimination of an individual based on ...
AB Robinson, Amy R. Gordon, B Hold, B Rosner, B Schaal, BG Green, BS Goodrich, C Wedekind, CJ Wysocki, CM Nieberding, D Muller-Schwarze, D Penn, DB Gower, EA Macdonald, EF Kean, F Bonadonna, F Eggert, GK Beauchamp, J Djordjevic, J Havlicek, JM Mateo, JN Labows, JN Lundstrom, JN Lundstrom, JN Lundstrom, JN Lundstrom, JN Lundstrom, JN Lundstrom, JN Lundstrom, JN Lundstrom, Johan N. Lundström, K Osada, K Osada, K Yamazaki, K Yamazaki, M Gallagher, M Nazzaro-Porro, Mats J. Olsson, MJ Baum, MJ Russell, MJ Sergeant, P Lenochova, P Wallace, PE Pochi, PG Hepper, R Brooks, RC Aitken, RH Porter, RL Doty, RL Doty, RL Olsen, S Haze, S Olsson, S Pierman, Susanna Mitro, T Hummel, Thomas Hummel, Y Martins   +57 more
core   +4 more sources

Profiling of urinary steroids aided by lithium ion adduction‐based ultrahigh‐performance liquid chromatography–tandem mass spectrometry

Rapid Communications in Mass Spectrometry, Volume 38, Issue 9, 15 May 2024.
Rationale As 3‐OH‐containing steroids are prone to dehydration by conventional electrospray ionization, reducing detection sensitivity, Li ion adduction‐based ultrahigh‐performance liquid chromatography–tandem mass spectrometry (UHPLC/MS/MS), developed to prevent dehydration and effectively detect 3‐OH steroids, was applied for profiling total and free
Yue Pan, Qiuyi Wang, Mengyao Chen, Toshifumi Takao   +3 more
wiley   +1 more source

Inhibition of the glucocorticoid‐activating enzyme 11β‐hydroxysteroid dehydrogenase type 1 drives concurrent 11‐oxygenated androgen excess

The FASEB Journal, Volume 38, Issue 7, 15 April 2024.
Co‐expression of the glucocorticoid‐activating enzyme HSD11B1 with the androgen‐activating enzyme AKR1C3 in adipose attenuates the biosynthesis of the 11‐oxygenated androgen, 11‐ketotestosterone. HSD11B1 inhibition leads to decreased local glucocorticoid activation but drives concurrent 11‐oxygenated androgen excess.
Lina Schiffer, Imken Oestlund, Jacky L. Snoep, Lorna C. Gilligan, Angela E. Taylor, Alexandra J. Sinclair, Rishi Singhal, Adrian Freeman, Ramzi Ajjan, Ana Tiganescu, Wiebke Arlt, Karl‐Heinz Storbeck   +11 more
wiley   +1 more source

The scent of attractiveness: levels of reproductive hormones explain individual differences in women's body odour [PDF]

, 2018
Individuals are thought to have their own distinctive body odour which reportedly plays an important role in mate choice. In the present study we investigated individual differences in body odours of women and examined whether some women generally smell ...
Fischbacher, Urs, Knoch, Daria, Lobmaier, Janek, Lobmaier, Janek S., Wirthmüller, Urs   +4 more
core   +2 more sources

Pulmonary arterial hypertension: Sex matters

British Journal of Pharmacology, Volume 181, Issue 7, Page 938-966, April 2024.
▪▪ Pulmonary arterial hypertension (PAH) is a complex disease of multifactorial origin. While registries have demonstrated that women are more susceptible to the disease, females with PAH have superior right ventricle (RV) function and a better prognosis than their male counterparts, a phenomenon referred to as the ‘estrogen paradox’.
Joshua P. Dignam, Smriti Sharma, Ioannis Stasinopoulos, Margaret R. MacLean   +3 more
wiley   +1 more source

A review of the analytical techniques for the detection of anabolic–androgenic steroids within biological matrices

WIREs Forensic Science, Volume 6, Issue 1, January/February 2024.
Although anabolic–androgenic steroid (AAS) use is increasing within the general population, detection of these compounds within forensic laboratories remains limited. It is therefore important to consider what substances are used, how they are administered and which are the most suitable analytical techniques for detection within the forensic context ...
Richard L. Harries, Giorgia De Paoli, Sarah Hall, Lorna A. Nisbet   +3 more
wiley   +1 more source