Results 11 to 20 of about 19,672 (173)

Aplastic Anemia [PDF]

open access: yesNew England Journal of Medicine, 2018
Aplastic anemia - bone marrow failure (AA) is defined as pancytopenia with hypocellular bone marrow without signs of marrow fibrosis or of presence of abnormal cells. Recent studies showed that most of AA cases might be mediated by immune mechanisms.
Thomas Menter, Alexandar Tzankov
  +7 more sources

Aplastic anemia [PDF]

open access: yesCurrent Opinion in Internal Medicine, 2008
Most acquired aplastic anemia is the result of immune-mediated destruction of hematopoietic stem cells causing pancytopenia and an empty bone marrow, which can be successfully treated with either immunosuppressive therapy or hematopoietic stem-cell transplantation.In aplastic anemia, oligoclonally expanded cytotoxic T cells induce apoptosis of ...
Neal S, Young   +2 more
openaire   +2 more sources

Aplastic anemia in China [PDF]

open access: yesJournal of Translational Internal Medicine, 2018
Abstract Aplastic anemia (AA) is a hematologic disease characterized by pancytopenia. Up to now, severe aplastic anemia (SAA) has been recognized by international and domestic scholars as an autoimmune disease with bone marrow (BM) failure mediated by the hyperfunctional T lymphocytes.
Chunyan Liu, Zonghong Shao
openaire   +3 more sources

The prognosis in aplastic anemia [PDF]

open access: yesBlood, 1975
Abstract The biphasic shape of the survival curve of 99 patients with aplastic anemia suggested that there may be at least two subgroups of patients with this disease, one with a very short survival and another with a longer survival. Patients who survived for 4 mo or less after the first clinic visit (group A) were different from the ...
Darryl M. Williams   +3 more
openaire   +4 more sources

Eltrombopag in Aplastic Anemia [PDF]

open access: yesSeminars in Hematology, 2015
The treatment of aplastic anemia is currently with immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) and cyclosporine, to which two thirds of patients respond. However, a significant proportion of these responders relapse and many have persistent cytopenias. The management of these patients is challenging.
Cynthia E. Dunbar   +4 more
openaire   +3 more sources

Pathogenesis of aplastic anemia [PDF]

open access: yesHematology, 2019
Aplastic anemia (AA) is a rare and life-threatening bone marrow failure (BMF) that results in peripheral blood cytopenia and reduced bone marrow hematopoietic cell proliferation. The symptoms are similar to myelofibrosis, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) making diagnosis of AA complicated.
Hong Liu, Li Wang
openaire   +3 more sources

Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study

open access: yesHaematologica, 2009
Background Associations between aplastic anemia and numerous drugs, pesticides and chemicals have been reported. However, at least 50% of the etiology of aplastic anemia remains unexplained.Design and Methods This was a case-control, multicenter ...
Eliane Maluf   +21 more
doaj   +1 more source

Aplastic Anemia in Pregnancy [PDF]

open access: yesThe Journal of Obstetrics and Gynecology of India, 2013
Although aplastic anemia was first recognized by Ehrlich in 1888, the pathogenesis of aplastic anemia has remained elusive. The prevalence of aplastic anemia in pregnancy is rare. Aplastic anemia is a subtype of anemia characterized by pancytopenia and a hypocellular bone marrow.
Annie Regi   +3 more
openaire   +3 more sources

Circulating thrombopoietin levels in normal healthy blood donors and in aplastic anemia patients in relation to disease severity

open access: yesAsian Journal of Transfusion Science, 2015
Background: Thrombopoietin (TPO) is the key hematopoietic growth factor regulating the production of platelets from bone marrow megakaryocytes and maintaining platelet hemostasis.
Abhay Singh   +4 more
doaj   +1 more source

Aplastic Anemia in a Developing Country: The Present and the Need [PDF]

open access: yesNational Journal of Laboratory Medicine, 2016
Introduction: Aplastic anemia (AA) a rare, yet a life threatening hematological disorder. Aplastic anemia if untreated results in very high mortality. Early diagnosis of Aplastic anemias is essential for appropriate management of the patient.
Ashwini BR , Seetu Palo, Siddiq M Ahmed
doaj   +1 more source

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