Results 41 to 50 of about 19,672 (173)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Response of Paroxysmal Nocturnal Hemoglobinuria Clone with Aplastic Anemia to Rituximab

Case Reports in Hematology, 2012
Paroxysmal nocturnal hemoglobinuria is caused by expansion of a hematopoietic stem cell clone with an acquired somatic mutation in the PIG-A gene. This mutation aborts the synthesis and expression of the glycosylphosphatidylinositol anchor proteins CD55
Radha Raghupathy, Olga Derman
doaj   +1 more source

Spontaneously resolved severe retinopathy associated with aplastic anemia

Oman Journal of Ophthalmology, 2021
Aplastic anemia is a rare, usually autoimmune disorder of bone marrow stem cells leading to pancytopenia and hypoplastic marrow that presents with anemia, infection or bleeding which can be potentially sight and life-threatening.
Washoo Mal, Mohamed Al-Abri
doaj   +1 more source

Food Safety Practices and Foodborne Illness in Italian Pediatric Oncology and Hematology Centers: A Survey on Behalf of the Infectious Disease Working Group of AIEOP

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Food safety practices are widely recommended for pediatric patients with cancer or undergoing hematopoietic stem cell transplantation (HCT) to mitigate foodborne infectious risks. However, specific measures, such as the neutropenic diet (ND) or low‐microbial diet, lack robust evidence and are inconsistently implemented across ...
Davide Leardini, Gianluca Bossù, Francesco Venturelli, Francesco Baccelli, Edoardo Muratore, Antonio Grasso, Pietro Gasperini, Chiara Pilotto, Letizia Pomponia Brescia, Nagua Giurici, Angelica Barone, Mariacristina Menconi, Elena Soncini, Daniela Onofrillo, Manuela Spadea, Francesco Fabozzi, Pietro Casartelli, Simona Rinieri, Maria Grazia Petris, Valeria Petroni, Paola Muggeo, Katia Perruccio, Cristina Meazza, Francesca Compagno, Francesco Paolo Tambaro, Maura Faraci, Angela Mastronuzzi, Riccardo Masetti, Simone Cesaro   +28 more
wiley   +1 more source

Bilateral Spontaneous Hyphemas in a Patient with Aplastic Anemia

Case Reports in Ophthalmology, 2018
Bilateral spontaneous hyphemas are a rare ophthalmic event. Aplastic anemia is a hematologic condition with well-documented manifestations in the posterior segment but not the anterior segment.
Mohammad Z. Siddiqui, Grant Gebhard, Alice Behrens, Ahmed Sallam, Sami Uwaydat   +4 more
doaj   +1 more source

Syndecan‐1 is Associated With Sinusoidal Obstruction Syndrome and Severe Acute Graft‐Versus‐Host Disease After Pediatric Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Endothelial damage may play a key role in several non‐infectious toxicities following hematopoietic stem cell transplantation (HSCT). We explored damage to the endothelial glycocalyx in 113 children undergoing HSCT by measuring syndecan‐1 plasma levels.
Denise Elbæk Horan, Sarah Weischendorff, Pär I. Johansson, Marianne Ifversen, Claus H. Nielsen, Klaus Müller, Katrine Kielsen   +6 more
wiley   +1 more source

Incidence of aplastic anemia in Bangkok. The Aplastic Anemia Study Group [PDF]

Blood, 1991
The annual incidence of aplastic anemia in metropolitan Bangkok, Thailand, and its five suburban provinces was prospectively determined. All patients first diagnosed during the period from January through December 1989 who met specific clinical and pathologic criteria were included. Thirty-two cases were identified, yielding an overall incidence of 3.7
David Kaufman, TE Anderson, Sathit Vannasaeng, N S Young, PE Leaverton, C Sriratanasatavorn, S Shapiro, Y Porapakkham, Anong Piankijagum, Surapol Issaragrisil   +9 more
openaire   +4 more sources

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan

Aging Cell, EarlyView.
In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam, Yang Yang, Mahbod Djamshidi, Sara Seifan, Nicholas S. Y. Ting, Joel Glover, Nicolas Touret, Paul M. K. Gordon, K. V. Vineetha Warriyar, Hokan Krowicki, Christine Kim Garcia, Sharon A. Savage, Aaron A. Goodarzi, Duncan M. Baird, Tara L. Beattie, Karl Riabowol   +15 more
wiley   +1 more source

Scurvy: A treatable forgotten fatal differential diagnosis and potential etiology of leukemia and aplastic anemia in pediatric population

Health Science Reports, 2023
Scurvy is a rare nutritional deficiency disease which is less likely to be suspected and it mostly lead to delayed diagnosis. It can present with features which can mislead clinicians to misdiagnose the condition as leukemia or aplastic anemia.
Harold L. Mashauri
doaj   +1 more source

Diagnosis and Management of Hypersensitivity to Antiplatelet Drugs: EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Antiplatelet drug (APD) therapy is the cornerstone for the prevention of atherosclerotic cardiovascular disease. The main APDs are aspirin and thienopyridines, particularly clopidogrel. These drugs may induce hypersensitivity reactions (HSRs).
Gabriele Cortellini, Alla Nakonechna, Annick Barbaud, Sevim Bavbek, Gianfranco Calogiuri, Inmaculada Doña, Violeta Kvedariene, Jose Julio Laguna Martinez, Serena Liberati, Mauro Pagani, Antonino Romano   +10 more
wiley   +1 more source