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Issues in Comprehensive Pediatric Nursing, 1980
Sickle-cell anemia is a genetic disorder characterized by abnormal hemoglobin. One out of every 500 black children in the United States is affected by this disease. Eight to ten percent of the black population has the sickle-cell trait. While other hemoglobinopathies have been identified that also produce erythrocyte sickling and destruction, the ...
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Sickle-cell anemia is a genetic disorder characterized by abnormal hemoglobin. One out of every 500 black children in the United States is affected by this disease. Eight to ten percent of the black population has the sickle-cell trait. While other hemoglobinopathies have been identified that also produce erythrocyte sickling and destruction, the ...
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Journal of the American Medical Association, 1950
The purpose of this report is to emphasize the possibility of the occasional early onset of sickle cell anemia and to consider it in the differential diagnosis of jaundice during the neonatal period in the Negro. Sickle cell anemia 1 is a hereditary and congenital disease of the hemopoietic system occurring almost entirely in members of the Negro race.
C A, FRAZIER, C E, RICE
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The purpose of this report is to emphasize the possibility of the occasional early onset of sickle cell anemia and to consider it in the differential diagnosis of jaundice during the neonatal period in the Negro. Sickle cell anemia 1 is a hereditary and congenital disease of the hemopoietic system occurring almost entirely in members of the Negro race.
C A, FRAZIER, C E, RICE
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Journal of Theoretical Biology, 1977
Abstract A number of metabolites have recently been investigated to determine whether or not they can prevent or reverse the sickling of red blood cells which contain the abnormal hemoglobin, hemoglobin S, of sickle cell anemia (SCA). An hypothesis is suggested in which one of these compounds, urea, may play a significant role in the precipitation of
Kirt J. Vener, Donald M. Perrill
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Abstract A number of metabolites have recently been investigated to determine whether or not they can prevent or reverse the sickling of red blood cells which contain the abnormal hemoglobin, hemoglobin S, of sickle cell anemia (SCA). An hypothesis is suggested in which one of these compounds, urea, may play a significant role in the precipitation of
Kirt J. Vener, Donald M. Perrill
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THE ADOLESCENT WITH SICKLE CELL ANEMIA
Hematology/Oncology Clinics of North America, 1996Adolescence is a time of intense change and turmoil. Helping patients with sickle cell disease have a smooth transition from the pediatric to adult health care environment is an important and meaningful experience. Facilitating the patient's transition, however, takes time and effort.
T R, Kinney, R E, Ware
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The electrocardiogram in sickle-cell anemia
American Heart Journal, 1955Abstract 1. 1. Sixty random patients with a hematologic diagnosis of sickle-cell anemia have been studied for clinical and electrocardiographic evidence of heart disease. 2. 2. The various types of electrocardiographic abnormalities have been discussed and compared with those found in the literature.
C L, LINDO, L R, DOCTOR
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Hypersplenism in Sickle Cell Anemia
Archives of Internal Medicine, 1964Although splenomegaly in children with sickle cell anemia is common, massive enlargement associated with thrombocytopenia and very severe anemia is rare. In such patients, splenectomy has been followed by increase in platelet count and hemoglobin concentration. This suggests that an acquired hypersplenism aggravated the hemolytic process.
E C, ROSSI +3 more
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Cholestasis in sickle cell anemia
The American Journal of Medicine, 1964Abstract A patient with sickle cell anemia who presented with marked cholestatic jaundice is described, with emphasis upon the difficulties encountered in differentiating this symptom complex from extrahepatic obstruction due to stone formation. This patient had extraordinarily high serum bilirubin levels, apparently the result of increased bilirubin ...
F M, KLION, M J, WEINER, F, SCHAFFNER
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PATHOPHYSIOLOGY OF SICKLE CELL ANEMIA
Hematology/Oncology Clinics of North America, 1996The anemia results from the markedly shortened circulatory survival of SS cells, together with a limited erythropoietic response. Both independent properties of Hb S-polymerization of the deoxy-Hb and instability of the oxy-Hb-contribute to early red cell destruction by effects on the Hb and on the red cell membranes.
R M, Bookchin, V L, Lew
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Archives of Pediatrics & Adolescent Medicine, 1958
Sickling can be produced in the blood of young Negro babies with sickle-cell trait. The percentage of cells showing this change is low but will increase as the infant matures. The homozygous state is present from birth; however, recognition of the symptomatic condition is rare in infants under the age of 4 months.
S L, LEIKIN, J W, McCOO
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Sickling can be produced in the blood of young Negro babies with sickle-cell trait. The percentage of cells showing this change is low but will increase as the infant matures. The homozygous state is present from birth; however, recognition of the symptomatic condition is rare in infants under the age of 4 months.
S L, LEIKIN, J W, McCOO
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The Inheritance of Sickle Cell Anemia
Science, 1949IF A DROP OF BLOOD is collected from each member of a randomly assembled series of American Negroes and sealed under a cover slip with vaseline, to be observed at intervals up to 72 hours, in the case of about 8 percent of the individuals composing the series a high proportion of the erythrocytes will be observed to assume various bizarre oat, sickle ...
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