Results 181 to 190 of about 5,052,415 (279)

The role of protein arginine methyltransferases in sickle cell‐mediated neurovascular impairments in mice

British Journal of Pharmacology, Volume 183, Issue 18, Page 5586-5601, September 2026.
Background and Purpose Sickle cell disease (SCD) is a hereditary blood disorder caused by mutation of β‐globin. In SCD, haemoglobin polymerization causes red blood cells to assume a rigid sickle‐shape leading to neurovascular alterations, including development of vascular dementia – characterized by cognitive impairment and reduced cerebral perfusion ...
Julia Zaccarelli‐Magalhães, Mariana Sayuri Berto Udo, Drew James Smith, Julia Langman, Luiz Henrique Matuguma, Guilherme Nagamine Gomes, Peter Rodriguez, Ammar Husan, Quanguang Zhang, Christopher G. Kevil, Cristiane Teresinha Citadin, Hung Wen Lin   +11 more
wiley   +1 more source

Predicting elevated transcranial doppler velocity among patients with sickle cell anemia in Uganda: A cross-sectional study. [PDF]

PLoS One
Nayiga D, Mukunya D, Odoch S, Oguttu F, Munabi I, Musaba MW, Kimbugwe C, Makoko BT, Babuya J, Mugabi J, Nyalihama A, Chebet M, Rynn L, Kizito S, Ssentumbwe V, Kiguli S, Olupot PO.   +16 more
europepmc   +1 more source

Posaconazole Target Attainment in Critically Ill Children: A 15‐Year Single‐Center Retrospective Analysis

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Posaconazole is a triazole antifungal agent used for prophylaxis and treatment of invasive fungal diseases. Posaconazole has high inter‐individual variability in dose‐exposure relationship and benefits from therapeutic drug monitoring (TDM). Adult studies report particularly high rates of subtherapeutic exposure among intensive care unit (ICU)
Kathryn Pavia, Addison Pritchett, Jennifer Goldman   +2 more
wiley   +1 more source

Real-world safety profile of twice a day deferiprone in patients with thalassemia, sickle cell disease, or other anemias. [PDF]

Blood Adv
Sheth S, Lal A, Appiah-Kubi A, Peslak SA, Toiber Temin N, Chen MA, Coates T.   +6 more
europepmc   +1 more source

Leg Ulcers in Thalassaemia: A Comparative Retrospective Review of Transfusion‐Dependent and Non‐Transfusion‐Dependent Patients

International Wound Journal, Volume 23, Issue 9, September 2026.
ABSTRACT To compare clinical and laboratory characteristics of transfusion‐dependent and non‐transfusion‐dependent beta thalassaemia patients with leg ulcers, and to identify contributing and protective factors We retrospectively reviewed 12 patients with beta thalassaemia and leg ulcers (seven transfusion‐dependent and five non‐transfusion‐dependent ...
Sacha El Khoury, Nicole Charbel, Farouk Kabbara, Joseph Klim, Ghida Ismail, Farah Ismail, Suzanne Koussa, Ali Taher   +7 more
wiley   +1 more source

Orbital Compression Syndrome Mimicking Severe Malaria in a Child with Sickle Cell Disease in a Ugandan Refugee Settlement: A Case Report. [PDF]

Int Med Case Rep J
Okema JN, Oryem SO, Atto LJ, Okello JO, Nalukenge JM, Acomo G, Obal R, Abong JA.   +7 more
europepmc   +1 more source

Interleukin-6 in hemolytic anemias: from inflammatory pathways to therapeutic targeting. [PDF]

Front Immunol
Zhao M, Yu X.
europepmc   +1 more source

Comment on: Managing sickle cell disease and related complications in pregnancy: results of an international Delphi panel. [PDF]

BMC Pregnancy Childbirth
Sharma D, Pamuk I, Ataga KI, Benachi A, Büyükkurt S, Lanzkron S, Ozdogu H, Pancham S, Pecker LH, Robinson SE, Baran SY.   +10 more
europepmc   +1 more source

Hidden burdens: The dual burden of subclinical iron deficiency and hemoglobinopathies in afro-descendant populations of Colombia's Pacific coast: A public health concern. [PDF]

J Public Health Res
Marquez B Y, Castillo B M, Mora B AI, Oliveros R AL, Castillo L LF, Marquez B B, Bernal JE, Briceño Balcazar I.   +7 more
europepmc   +1 more source