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Cholestasis in sickle cell anemia
The American Journal of Medicine, 1964Abstract A patient with sickle cell anemia who presented with marked cholestatic jaundice is described, with emphasis upon the difficulties encountered in differentiating this symptom complex from extrahepatic obstruction due to stone formation. This patient had extraordinarily high serum bilirubin levels, apparently the result of increased bilirubin ...
F M, KLION, M J, WEINER, F, SCHAFFNER
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PATHOPHYSIOLOGY OF SICKLE CELL ANEMIA
Hematology/Oncology Clinics of North America, 1996The anemia results from the markedly shortened circulatory survival of SS cells, together with a limited erythropoietic response. Both independent properties of Hb S-polymerization of the deoxy-Hb and instability of the oxy-Hb-contribute to early red cell destruction by effects on the Hb and on the red cell membranes.
R M, Bookchin, V L, Lew
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Archives of Pediatrics & Adolescent Medicine, 1958
Sickling can be produced in the blood of young Negro babies with sickle-cell trait. The percentage of cells showing this change is low but will increase as the infant matures. The homozygous state is present from birth; however, recognition of the symptomatic condition is rare in infants under the age of 4 months.
S L, LEIKIN, J W, McCOO
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Sickling can be produced in the blood of young Negro babies with sickle-cell trait. The percentage of cells showing this change is low but will increase as the infant matures. The homozygous state is present from birth; however, recognition of the symptomatic condition is rare in infants under the age of 4 months.
S L, LEIKIN, J W, McCOO
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The Inheritance of Sickle Cell Anemia
Science, 1949IF A DROP OF BLOOD is collected from each member of a randomly assembled series of American Negroes and sealed under a cover slip with vaseline, to be observed at intervals up to 72 hours, in the case of about 8 percent of the individuals composing the series a high proportion of the erythrocytes will be observed to assume various bizarre oat, sickle ...
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Sickle Cell Anemia and Hearing
Annals of Otology, Rhinology & Laryngology, 1980The present investigation examined the effects of sickle cell anemia on threshold hearing. The study included 43 homozygous sickle cell anemia patients, ages 7–18 years, and 23 age-matched controls with documented normal hemoglobin. Both the study and control groups received otologic and audiologic examinations.
E M, Friedman +3 more
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JAMA: The Journal of the American Medical Association, 1963
Four patients presenting unusual manifestations of sickle cell anemia were studied. Clinical variants were age, habitus, and pregnancy. In some cases, these features were so atypical as to suggest disease entities other than sickle cell anemia and obscure the diagnosis.
R C, GAUSE +3 more
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Four patients presenting unusual manifestations of sickle cell anemia were studied. Clinical variants were age, habitus, and pregnancy. In some cases, these features were so atypical as to suggest disease entities other than sickle cell anemia and obscure the diagnosis.
R C, GAUSE +3 more
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The Treatment of Sickle Cell Anemia
Archives of Internal Medicine, 1974"Sickle cell crisis" is a diagnosis made by exclusion, and infection must be ruled out as a cause of symptoms whenever a patient becomes acutely ill. Partial exchange transfusion is an important therapeutic tool, for it seems to interrupt "the vicious cycle of sickling" in some instances and forestall it in others.
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Sickle Cell Anemia and Pregnancy
Postgraduate Medicine, 1952A study was made of 18 cases of sickle cell anemia, 4 of which were complicated by pregnancy. These 4 cases are reported in detail, including the postmortem findings for one of them. The frequency of the various symptoms of sickle cell anemia and a summary of the cases complicated by pregnancy are presented in tabulated form.
R, CHARET, R, WALTMAN, H, FERNBACH
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Cholecystectomy in Sickle Cell Anemia
Archives of Pediatrics & Adolescent Medicine, 1989Sir.—In the July 1988 issue ofAJDC, Malone and Werlin1reported the resuits of preoperative transfusion before elective cholecystectomy at the time of diagnosis of cholelithiasis in children with sickle cell anemia. Our own practice supports the conclusions of this study. From 1976 to 1988, 240 children have been seen at the sickle cell clinic.
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Splenectomy in Sickle Cell Anemia
Archives of Internal Medicine, 1970Sickle cell anemia is a severe hemolytic disease caused by a congenital hemoglobin defect for which there is no treatment. Clinical management of patients with the disorder is purely symptomatic, and a "hands off" policy regarding transfusion is best.
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