Results 11 to 20 of about 205,200 (274)

Peripheral Red Blood Cell Split Chimerism as a Consequence of Intramedullary Selective Apoptosis of Recipient Red Blood Cells in a Case of Sickle Cell Disease

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Allogeneic cellular gene therapy through hematopoietic stem cell transplantation is the only radical cure for congenital hemoglobinopathies like thalassemia and sickle cell anemia.
Marco Marziali, Antonella Isgrò, Pietro Sodani, Javid Gaziev, Daniela Fraboni, Katia Paciaroni, Cristiano Gallucci, Cecilia Alfieri, Andrea Roveda, Gioia De Angelis, Luisa Cardarelli, Michela Ribersani, Marco Andreani, Guido Lucarelli   +13 more
doaj   +1 more source

Primary stroke in a woman with sickle cell anemia responsive to hydroxyurea therapy. [PDF]

, 2014
The most common cause of stroke in children with sickle cell anemia is infarction due to ischemia. In adults, however, stroke is most commonly hemorrhagic in nature. Other causes of stroke in patients with sickle cell disease are very rare. In this short
Ballas, Samir K., Martinez-Outshoorn, Ubaldo E., Savage, Michael P   +2 more
core   +2 more sources

Frequency distribution of sickle cell anemia, sickle cell trait and sickle/beta-thalassemia among anemic patients in Saudi Arabia

Journal of Natural Science Biology and Medicine, 2015
Background: Notwithstanding, the growing incidence of sickle cell hemoglobinopathies (SCH) such as sickle cell anemia (SCA) or sickle cell disease, sickle/beta-thalassemia; the exact prevalence remains obscure in Saudi Arabia.
M. Elsayid, Mohammed Al-Shehri, Yasser Abdullah Alkulaibi, A. Alanazi, Shoeb Qureshi   +4 more
semanticscholar   +1 more source

Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa.

New England Journal of Medicine, 2020
BACKGROUND Hydroxyurea has proven safety, feasibility, and efficacy in children with sickle cell anemia in sub-Saharan Africa, with studies showing a reduced incidence of vaso-occlusive events and reduced mortality.
C. John, R. Opoka, Teresa S. Latham, H. Hume, Catherine Nabaggala, Phillip Kasirye, C. Ndugwa, A. Lane, R. Ware   +8 more
semanticscholar   +1 more source

Haploidentical HSCT for hemoglobinopathies: improved outcomes with TCRαβ+/CD19+-depleted grafts

Blood Advances, 2018
: We examined outcomes of haploidentical hematopoietic cell transplantation (haplo-HCT) using T-cell receptor αβ+ (TCRαβ+)/CD19+-depleted grafts (TCR group, 14 patients) in children with hemoglobinopathies.
Javid Gaziev, Antonella Isgrò, Pietro Sodani, Katia Paciaroni, Gioia De Angelis, Marco Marziali, Michela Ribersani, Cecilia Alfieri, Alessandro Lanti, Tiziana Galluccio, Gaspare Adorno, Marco Andreani   +11 more
doaj   +1 more source

Murine models of sickle cell disease and beta‐thalassemia demonstrate pulmonary hypertension with distinctive features

Pulmonary Circulation, 2021
Sickle cell anemia and β‐thalassemia intermedia are very different genetically determined hemoglobinopathies predisposing to pulmonary hypertension. The etiologies responsible for the associated development of pulmonary hypertension in both diseases are ...
Paul W. Buehler, Delaney Swindle, David I. Pak, Mehdi A. Fini, Kathryn Hassell, Rachelle Nuss, Rebecca B. Wilkerson, Angelo D’Alessandro, David C. Irwin   +8 more
doaj   +1 more source

The Fabulous Impact of CRISPR Method in Sickle Cell Disease Treatment

Trends in Peptide and Protein Sciences, 2021
Sickle cell diseases are the most prevalent monogenic blood diseases with complications such as severe end-organ harm, pain, and reduced life expectancy. Dealing options for sickle cell diseases are inadequate, as there are just two FDA-approved drugs to
Vida Ebrahimi, Atieh Hashemi
doaj   +1 more source

Mortality in children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil. [PDF]

, 2018
OBJECTIVE: To determine the mortality rate of children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil. METHODS: The number of deaths, the mortality rate and the causes of deaths in patients with sickle cell anemia who were ...
Ballas, Samir K., Freitas, Thiago Gotelip de, Jesus, Leonardo José Carvalho de, Lobo, Clarisse Lopes de Castro, Lugon, Jocemir Ronaldo, Nascimento, Emilia Matos do   +5 more
core   +3 more sources

The multifaceted role of ischemia/reperfusion in sickle cell anemia.

Journal of Clinical Investigation, 2020
Sickle cell anemia is a unique disease dominated by hemolytic anemia and vaso-occlusive events. The latter trigger a version of ischemia/reperfusion (I/R) pathobiology that is singular in its origin, cyclicity, complexity, instability, perpetuity, and ...
R. Hebbel, J. Belcher, G. Vercellotti
semanticscholar   +1 more source

Fetal Hemoglobin in Sickle Cell Anemia.

Blood, 2020
Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course and offer prospects for curative therapy of sickle cell disease. This review focuses on: 1.
M. Steinberg
semanticscholar   +1 more source