Results 11 to 20 of about 71,196 (274)
The Fabulous Impact of CRISPR Method in Sickle Cell Disease Treatment
Trends in Peptide and Protein Sciences, 2021 Sickle cell diseases are the most prevalent monogenic blood diseases with complications such as severe end-organ harm, pain, and reduced life expectancy. Dealing options for sickle cell diseases are inadequate, as there are just two FDA-approved drugs to
Vida Ebrahimi, Atieh Hashemi
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Primary stroke in a woman with sickle cell anemia responsive to hydroxyurea therapy. [PDF]
, 2014 The most common cause of stroke in children with sickle cell anemia is infarction due to ischemia. In adults, however, stroke is most commonly hemorrhagic in nature. Other causes of stroke in patients with sickle cell disease are very rare. In this short
Ballas, Samir K. +2 more
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Mortality in children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil. [PDF]
, 2018 OBJECTIVE: To determine the mortality rate of children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil. METHODS: The number of deaths, the mortality rate and the causes of deaths in patients with sickle cell anemia who were ...
Ballas, Samir K. +5 more
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Comorbidities in aging patients with sickle cell disease. [PDF]
, 2018 Sickle cell disease (SCD) in general and sickle cell anemia in particular is a highly complex disorder both at the molecular and clinical levels. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing ...
Ballas, Samir K.
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Haematologica, 2013 The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57
Xavier Waltz +12 more
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JAMA: The Journal of the American Medical Association, 1922 Recent medical literature contains the records of three patients, all negroes, or negroes with an admixture of Caucasian blood, in whom severe anemia, characterized by certain peculiar morphologic alterations of the red blood cells, was present. The first case was reported by Herrick.1Washburn2published the records of a patient whose blood showed ...
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Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania
Haematologica, 2011 Background Reduced growth is common in children with sickle cell anemia, but few data exist on associations with long-term clinical course. Our objective was to determine the prevalence of malnutrition at enrolment into a hospital-based cohort and ...
Sharon E. Cox +8 more
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BMC Research Notes, 2018 Objective By measuring the associations between the presence of sickle cell and β-thalassemia genes, we assessed the extent to which these hemoglobinopathies contribute to the high prevalence of anemia observed in preschool-aged children and women of ...
James P. Wirth +4 more
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Safety and efficacy of blood exchange transfusion for priapism complicating sickle cell disease. [PDF]
, 2016 BACKGROUND: Priapism is unwanted painful penile erection that affects about 36% of boys and men with sickle cell disease (SCD) most of whom have sickle cell anemia. Clinically, priapism could be stuttering, minor, or major.
Adeyoju +23 more
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Treating sickle cell anemia [PDF]
Science, 2020 New drugs, stem cell transplants, and gene therapy show promise in treating sickle cell ...
John F, Tisdale +2 more
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