Results 21 to 30 of about 34,389 (155)

The Fabulous Impact of CRISPR Method in Sickle Cell Disease Treatment

open access: yesTrends in Peptide and Protein Sciences, 2021
Sickle cell diseases are the most prevalent monogenic blood diseases with complications such as severe end-organ harm, pain, and reduced life expectancy. Dealing options for sickle cell diseases are inadequate, as there are just two FDA-approved drugs to
Vida Ebrahimi, Atieh Hashemi
doaj   +1 more source

Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease

open access: yesHaematologica, 2013
The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57
Xavier Waltz   +12 more
doaj   +1 more source

Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania

open access: yesHaematologica, 2011
Background Reduced growth is common in children with sickle cell anemia, but few data exist on associations with long-term clinical course. Our objective was to determine the prevalence of malnutrition at enrolment into a hospital-based cohort and ...
Sharon E. Cox   +8 more
doaj   +1 more source

Sickle Cell Anemia [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1922
Recent medical literature contains the records of three patients, all negroes, or negroes with an admixture of Caucasian blood, in whom severe anemia, characterized by certain peculiar morphologic alterations of the red blood cells, was present. The first case was reported by Herrick.1Washburn2published the records of a patient whose blood showed ...
openaire   +1 more source

Association between sickle cell and β-thalassemia genes and hemoglobin concentration and anemia in children and non-pregnant women in Sierra Leone: ancillary analysis of data from Sierra Leone’s 2013 National Micronutrient Survey

open access: yesBMC Research Notes, 2018
Objective By measuring the associations between the presence of sickle cell and β-thalassemia genes, we assessed the extent to which these hemoglobinopathies contribute to the high prevalence of anemia observed in preschool-aged children and women of ...
James P. Wirth   +4 more
doaj   +1 more source

Prevalence of sickle cell disease and sickle cell trait in national neonatal screening studies

open access: yesRevista Brasileira de Hematologia e Hemoterapia, 2011
Sickle cell anemia is the best known hereditary blood disorder; there are serious complications associated with the condition. Diagnosis and early intervention reduce morbidity and mortality.
Luciana Garcia Lervolino   +5 more
doaj   +1 more source

Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous Artesunate

open access: yesCase Reports in Infectious Diseases, 2019
Treatment of severe malaria with artemisinin derivatives in patients with comorbid conditions such as sickle cell anemia must be considered with precaution.
Abdulrahman Hummadi   +3 more
doaj   +1 more source

Machine Learning Approach for Classification of Sickle Cell Anemia in Teenagers Based on Bayesian Network

open access: yesJournal of Information Systems and Informatics, 2023
In this study, we employed a Bayesian network approach for the classification of sickle cell anemia in teenagers based on their medical data. Sickle cell anemia is a hereditary blood disorder characterized by the presence of abnormal hemoglobin, leading
Blessing Ekong   +4 more
doaj   +1 more source

Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

open access: yesHaematologica, 2009
Background Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation.
Julien Tripette   +10 more
doaj   +1 more source

Prevalence of Haemoglobine s in Araraquara-SP Population.

open access: yesRevista Brasileira Multidisciplinar - ReBraM /Brazilian Multidisciplinay Journal, 2015
The Sickle Cell Anemia is a genetic hemoglobionopathy, characterized by an alteration in the hemoglobin molecule struture (HbA1), called hemoglobin S (HbS), which causes a distortion in the erythocytes structure, changing from spherical shape to sickle ...
Bruno Rocha de Jesus   +4 more
doaj   +1 more source

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