Invasive bacterial infections in Gambians with sickle cell anaemia in an era of widespread Pneumococcal and Haemophilus influenzae type B vaccination [PDF]
, 2016 Background: There is relatively little data on the aetiology of bacterial infections in patients with sickle cell anaemia (SCA) in West Africa, and no data from countries that have implemented conjugate vaccines against both Streptococcus pneumoniae and ...
Anderson, ST +5 more
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Prevalence of Haemoglobine s in Araraquara-SP Population.
Revista Brasileira Multidisciplinar - ReBraM /Brazilian Multidisciplinay Journal, 2015 The Sickle Cell Anemia is a genetic hemoglobionopathy, characterized by an alteration in the hemoglobin molecule struture (HbA1), called hemoglobin S (HbS), which causes a distortion in the erythocytes structure, changing from spherical shape to sickle ...
Bruno Rocha de Jesus +4 more
doaj +1 more source
Studies on the Hemoglobin of Cooley's Anemia and Cooley's Trait [PDF]
, 1952 The diseases sickle cell anemia and Cooley's anemia (also known as thalassemia or Mediterranean anemia) have associated with them "minor" or "trait" forms of the disease in which the symptomatology is minimal, and the abnormalities in the red cells are ...
Rich, Alexander
core
Sickle Cell Anemia and Its Phenotypes.
Annual review of genomics and human genetics (Print), 2018 In the 100 years since sickle cell anemia (SCA) was first described in the medical literature, studies of its molecular and pathophysiological basis have been at the vanguard of scientific discovery.
T. Williams, S. Thein
semanticscholar +1 more source
Drugs for preventing red blood cell dehydration in people with sickle cell disease. [PDF]
, 2016 BACKGROUND: Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells. These are rigid and may block blood vessels leading to acute painful crises and other complications.
Ballas, Samir K., Nagalla, Srikanth
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Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Advanced Science, EarlyView.Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen +19 more
wiley +1 more source
Haematologica, 2012 Background Little is known about the effects of blood rheology on the occurrence of acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia and hemoglobin SC disease.Design and Methods To address this issue, steady ...
Yann Lamarre +13 more
doaj +1 more source
Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population [PDF]
Genetics and Molecular Biology, 2020 Fetal hemoglobin (HbF) is a determining factor for the development of sickle cell anemia. High HbF levels lower the intensity of symptoms of this disease. HbF levels can vary in patients with sickle cell anemia and individuals without the disease.
Cristian Fong +2 more
doaj +1 more source
The Virginia Sickle Cell Anemia Awareness Program: Education, Screening, and Counseling [PDF]
, 1977 In 1968, a program of screening for sickle trait carriers was begun as part of the work of the Hematology Division, Department of Medicine, at the Medical College of Virginia.
Cooper, Florence N., Scott, Robert B.
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Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature [PDF]
, 2013 Sickle cell disease can lead to hepatic complications ranging from acute hepatic crises to chronic liver disease including intrahepatic cholestasis, and iron overload.
Blinder, Morey A. +7 more
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