Results 71 to 80 of about 35,347 (227)

Association between hemolysis and albuminuria in adults with sickle cell anemia

Haematologica, 2012
Studies have questioned whether renal dysfunction in sickle cell disease is linked to hemolysis-associated vasculopathy. We have investigated renal function and markers of hemolysis in a cohort of 424 adult African-British patients with sickle cell ...
Thomas G. Day, Emma R. Drasar, Tony Fulford, Claire C. Sharpe, Swee Lay Thein   +4 more
doaj   +1 more source

Evaluating high‐sensitivity troponin levels in people with sickle cell disease in the emergency department

British Journal of Haematology, EarlyView.
This study shows that sickle cell disease patients have elevated high‐sensitivity cardiac troponin I (hs‐cTnI) that is not considered clinically significant but are outside of the normal range. Elevated hs‐cTnI was associated with low haemoglobin and a history of heart failure.
Abdelrhman Mohammed, Najibah A. Galadanci, Gerhard Hellemann, Julie Kanter   +3 more
wiley   +1 more source

Distal renal tubular acidosis in sickle cell anemia

Saudi Journal of Kidney Diseases and Transplantation, 2018
We report a rare case of two young male siblings with sickle cell anemia who presented with bilateral lower limb deformities, failure to thrive, polyuria, and polydipsia.
Anjali Bharani, Rani Manchanda, Ritesh Kumar Singh, Swati Prashant   +3 more
doaj   +1 more source

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

Predict less, prevent more: A familiar mantra for sickle cell anaemia?

British Journal of Haematology, EarlyView.
Commentary on: Sommet J, Boizeau P, Haouari Z, et al. Identification of predictive factors for reversal of cerebral vasculopathy in an original longitudinal cohort study in newborns with sickle cell anaemia. Br J Haematol. 2026 (Online ahead of print). doi: 10.1111/bjh.70726.
Charles T. Quinn
wiley   +1 more source

Adrenal Myelolipoma, Cholelithiasis and Calcified Spleen: Retrospective Diagnosis of Sickle Cell Anemia Using a Novel Triad of Abdominal Imaging Findings

Acta Medica Indonesiana, 2016
Sickle cell anemia is an inherited abnormality of the globin chain with very high prevalence in the Indian subcontinent. A significant proportion of these patients present late in life and are at a risk of complications like acute chest syndrome and ...
Sandeep G Jakhere, Raju S Kumbhar, Harshal V Dhongade   +2 more
doaj   +2 more sources

Tracking Telehealth Needs for Individuals With Sickle Cell Disease Through the COVID‐19 Pandemic: A Cross‐Sectional Survey Study

Health Science Reports
Background and Aim Pervasive disparities characterize sickle cell disease (SCD) care, including limited access to SCD specialists. Rapid deployment of remote healthcare provision and support during the COVID‐19 pandemic provides an opportunity to ...
Marsha Treadwell, Lisa Du, Yemi Lawrence, Maxine Gaspar, Kathryn Hassell, Sanjay Shah, Moses Akpan, Nicole Crook, Marcia Taylor, Srila Gopal, For the Pacific Sickle Cell Regional Collaborative   +10 more
doaj   +1 more source

A Phase Ib open label, randomized, safety study of SANGUINATE™ in patients with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia
Background: Treatment of sickle cell anemia is a challenging task and despite the well understood genetic and biochemical pathway of sickle hemoglobin, current therapy continues to be limited to the symptomatic treatment of pain, supplemental oxygen ...
Hemant Misra, James Bainbridge, John Berryman, Abraham Abuchowski, Kenneth Mauricio Galvez, Luis Fernando Uribe, Angel Luis Hernandez, Nestor Rodolfo Sosa   +7 more
doaj   +1 more source

Craniofacial bone abnormalities and malocclusion in individuals with sickle cell anemia: a critical review of the literature

Revista Brasileira de Hematologia e Hemoterapia, 2012
This study aims to critically review the literature in respect to craniofacial bone abnormalities and malocclusion in sickle cell anemia individuals.
Cyrene Piazera Silva Costa, Halinna Larissa Cruz Correia de Carvalho, Erika Bárbara Abreu Fonseca Thomaz, Soraia de Fátima Carvalho Sousa   +3 more
doaj   +1 more source

Identification of predictive factors for reversal of cerebral vasculopathy in an original longitudinal cohort study in newborns with sickle cell anaemia

British Journal of Haematology, EarlyView.
Summary Cerebral macrovasculopathy (CV) is a major complication in children with sickle cell anaemia (SCA) and usually requires a long‐term transfusion programme (TP) to prevent stroke. This study aimed to identify factors predicting reversal of CV on TP in a single‐centre newborn cohort. Among 375 patients, 50 presented CV and received TP.
Julie Sommet, Priscilla Boizeau, Zinedine Haouari, Berengère Koehl, Monique Elmaleh, Emmanuelle Lesprit, Florence Missud, Ghislaine Ithier, Laurent Holvoet, Valentine Brousse, Christophe Delclaux, André Denjean, Suzanne Verlhac, Corinne Alberti, André Baruchel, Nathalie Couque, Malika Benkerrou   +16 more
wiley   +1 more source