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Research progress on pharmacological actions and molecular mechanisms of Anemoside B4

Pharmacological Research - Modern Chinese Medicine, 2023
Anemoside B4 (AB4), as an important ingredient of Chinese herb Pulsatilla Chinensis, has been used in Chinese ancient medicine for thousands of years with exact therapeutic effects of anti-inflammation and anti-tumor.
Tianming Lu, Qixin Wang, Minghong Zhao, Jigang Wang, Qiuyan Guo   +4 more
doaj   +5 more sources

Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation [PDF]

Frontiers in Immunology
Abdominal aortic aneurysm (AAA) is a degenerative disease characterized by local abnormal dilation of the aorta accompanied by vascular smooth muscle cell (VSMC) dysfunction and chronic inflammation.
Shuhan Chu, Shuhan Chu, Dan Shan, Luling He, Shilin Yang, Yulin Feng, Yifeng Zhang, Jun Yu   +7 more
doaj   +6 more sources

Effect of anemoside B4 on ameliorating cerebral ischemic/reperfusion injury [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Anemoside B4 (AB4) is a multifunctional compound with anti-inflammatory, anti-apoptotic, antioxidant, antiviral, and autophagy-enhancing effects. However, the role of AB4 in cerebral ischemia/reperfusion injury (CIRI) remains obscure.
Fei Huizhi, Xiaohuan Huang
doaj   +4 more sources

Pharmacokinetics and safety evaluation of anemoside B4 in healthy Beagle dogs [PDF]

Frontiers in Veterinary Science
BackgroundAnemoside B4 (AB4), a pentacyclic triterpenoid saponin extracted from the traditional Chinese medicinal herb Pulsatilla chinensis, has shown anti-inflammatory and immunomodulatory effects in both preclinical and clinical studies.
Jinzhao Ji, Jinzhao Ji, Yuqiao Ma, Yuqiao Ma, Shaobing Wan, Shaobing Wan, Xiaoqing Ding, Xiaoqing Ding, Jingyu Wang, Jingyu Wang, Yongcheng Zhong, Yongcheng Zhong, Yangyang Song, Junqing Zhao, Zhetong Su, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li   +18 more
doaj   +5 more sources

Anemoside B4 Protects against Acute Lung Injury by Attenuating Inflammation through Blocking NLRP3 Inflammasome Activation and TLR4 Dimerization [PDF]

Journal of Immunology Research, 2020
Acute lung injury (ALI) is an acute inflammatory process in the lung parenchyma. Anemoside B4 (B4) was isolated from Pulsatilla, a plant-based drug against inflammation and commonly applied in traditional Chinese medicine.
Renyikun Yuan, Jia He, Liting Huang, Li-Jun Du, Hongwei Gao, Qiongming Xu, Shilin Yang   +6 more
doaj   +3 more sources

Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury [PDF]

Frontiers in Pharmacology
IntroductionAnemoside B4 (AB4), a major bioactive saponin isolated from the roots of Pulsatilla chinensis, exhibits anti-inflammatory and antioxidant properties.
Yue Bu, Yue Bu, Yue Bu, Zhixi Li, Zhixi Li, Zhixi Li, Cheng Wang, Yongjing Yu, Yongjing Yu, Yongjing Yu, Chang Liu, Chang Liu, Chang Liu, Yue Sun, Zhenyu Sun, Zhenyu Sun, Weidong Gong, Weidong Gong, Juan Luo, Juan Luo, Ziyong Yue, Ziyong Yue   +21 more
doaj   +4 more sources

Self-Assembled Carrier-Free Nanostructures of Anemoside B4 and Oleanolic Acid Alleviate Intestinal Injury Induced by Intraperitoneal Escherichia coli Challenge in Mice [PDF]

Antioxidants
Escherichia coli-induced enteritis imposes a substantial economic burden on the global livestock industry. In the current context of reducing and restricting antibiotic use, there is an urgent need for novel therapeutic strategies.
Jianchi Lun, Yuxin Yan, Junji Huang, Rong Chen, Yimu Ma, Mengjie Liu, Qian Qu, Weijie Lv, Shining Guo   +8 more
doaj   +3 more sources

Anemoside B4 alleviates ulcerative colitis by attenuating intestinal oxidative stress and NLRP3 inflammasome via activating aryl hydrocarbon receptor through remodeling the gut microbiome and metabolites [PDF]

Redox Biology
Ulcerative colitis (UC) is a chronic, non-specific inflammatory disease of the intestines with a significant increase in global incidence in recent years. Oxidative stress and inflammation are two hallmarks of UC pathogenesis.
Hao Wu, Yao-lei Li, Yu Wang, Yu-ge Wang, Jia-hui Hong, Mi-mi Pang, Pan-miao Liu, Jian-jun Yang   +7 more
doaj   +3 more sources

Anemoside B4 Rectal Thermosensitive In Situ Gel to Treat Ulcerative Colitis by Overcoming Oral Bioavailability Barriers with Absorption Enhancer-Assisted Delivery [PDF]

Pharmaceutics
Background: Anemoside B4 (AB4), the major bioactive saponin from Pulsatilla chinensis, exhibits anti-inflammatory, anti-tumor, anti-apoptotic, and analgesic properties.
Xiaomeng Lei, Canjian Wang, Mingyan Xia, Guansheng Zhang, Tangxun Wang, Yang Chen, Yufang Huang, Tiantian Wang, Dongxun Li, Wenliu Zhang, Guosong Zhang   +10 more
doaj   +3 more sources

Anemoside B4 mitigates endoplasmic reticulum stress-induced apoptosis post cerebral ischemia/reperfusion injury in rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Anemoside B4 (AB4) exhibits neuroprotective effects on cerebral ischemia/reperfusion injury (CIRI), and endoplasmic reticulum stress (ERS) plays a crucial role in the process of CIRI.
Xiaohuan Huang, Ran Deng, Chaoyue Ma, Huizhi Fei   +3 more
doaj   +5 more sources