Innovative Strategies in Natural Product Drug Discovery: The Case of Anemoside B4
EngineeringAnemoside B4 (AB4), a triterpenoidal saponin derived from Pulsatilla chinensis, has garnered considerable attention for its potent anti-inflammatory and immunomodulatory activities, culminating in its approval for clinical trials by the Center for Drug ...
Naixin Kang +9 more
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Anemoside B4 attenuates intestinal damage in chickens infected with Eimeria tenella: Mechanisms involving antioxidant defense, immune modulation, and barrier repair [PDF]
Poultry ScienceThis study aimed to investigate the reparative effects and underlying mechanisms of Anemoside B4 (AB4) on intestinal damage induced by Eimeria tenella (E. tenella) infection in chickens. Eighty 14-day-old broilers were allocated into four groups: control
Mohan Yang +8 more
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Effect of anemoside B4 on milk whey in clinical mastitis-affected cows elucidated using tandem mass tag (TMT)-based quantitative proteomics [PDF]
Scientific Reports, 2022 Intramuscular injection of anemoside B4 (AB4) has a superior therapeutic effect on clinical mastitis in lactating cows. Here, we explored AB4’s effect on milk whey in clinical mastitis-affected cows using proteomics.
Liu-hong Shen +6 more
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Antiviral and immunoregulatory role against PCV2 in vivo of Chinese herbal medicinal ingredients
Journal of Veterinary Research, 2017 Introduction: The aim of the research was to investigate the antiviral and immunoregulatory effects of saikosaponin A, saikosaponin D, Panax notoginseng saponins, notoginsenoside R1, and anemoside B4 saponins commonly found in Chinese herbal medicines.
Yang Haifeng +4 more
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ACS Applied Materials & Interfaces, 2022 Combination therapy has gained a lot of attention thanks to its superior activity against cancer. In the present study, we report a cRGD-targeted liposomal preparation for co-delivery of programmed cell death ligand 1 (PD-L1) small interfering RNA (siRNA)
Xiong Zhou (1417804) +11 more
core +3 more sources
The Combination of Chinese Medicine Monomers Reduces 7S Globulin-Induced Damage to IPEC-J2 Cells In Vitro by Modulating NF-κB/MAPK Pathway-Related Markers [PDF]
Veterinary SciencesThis study aimed to explore the protective effects of different concentration combinations of four traditional Chinese medicine (TCM) monomers (Eleutheroside E, Anemoside B4, Forsythoside A, and Esculin) on porcine intestinal epithelial cell (IPEC-J2 ...
Ya Wang +9 more
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Decoding anemoside B4: Core mechanistic axes and an omics-to-atom paradigm
Pharmacological ResearchAnemoside B4 (AB4), a prominent triterpenoid saponin from Pulsatilla chinensis, has advanced to NMPA-approved clinical trials for ulcerative colitis.
Xinyi Zou +6 more
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Integrated Multi-Omics Analysis Explores the Protective Effects and Potential Mechanisms of Pulsatilla chinensis on Canine Antibiotic-Associated Diarrhea [PDF]
BiomoleculesDiarrhea is a common gastrointestinal disorder in animals, often worsened by antibiotic use. Pulsatilla chinensis (PC) is traditionally used for gastrointestinal issues, but its bioactive constituents and mechanisms remain unclear.
Zixuan Zhao +9 more
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Italian Journal of Animal Science(1) Background: The therapeutic efficacy of AB4 in cows with CM is well-established, but the specific mechanism remains to be explored. This study was based on Label free relative quantitative proteomics technology to reveal the internal mechanism of AB4
Zeru Zhang +8 more
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AB4-Loaded Nanomicelle Hydrogel Promotes Targeting of the Dysregulated Diabetic Wound Microenvironment via Coordinated Multistage Repair [PDF]
Gels(1) Background: Impaired diabetic wound healing stems from systemic dysregulation of the wound-healing cascade under hyperglycemic conditions, producing a disordered microenvironment marked by sustained inflammation, defective angiogenesis, and aberrant ...
Xue Shao +9 more
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