Results 151 to 160 of about 582,109 (258)

Associations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to determine whether pollutants such as fire smoke–related particulate matter <2.5 μm (PM2.5) are associated with incident rheumatoid arthritis (RA) and RA‐associated interstitial lung disease (RA‐ILD). Methods This patient–control study used Veterans Affairs (VA) data from October 1, 2009, to December 31, 2018.
Vanessa L. Kronzer, Yangyuna Yang, Punyasha Roul, James L. Crooks, Cynthia S. Crowson, John M. Davis III, Jeffrey A. Sparks, Jeffrey R. Pierce, Katelyn O'Dell, Brian C. Sauer, Grant W. Cannon, Joshua F. Baker, Ted R. Mikuls, Bryant R. England   +13 more
wiley   +1 more source

Long‐Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The phase 3 MIRRA trial demonstrated efficacy and safety of mepolizumab, anti‐interleukin‐5 biologic, for EGPA.
Michael E. Wechsler, Jared Silver, Gerhard Wolff, Robert G. Price, Rejina Verghis, Peter F. Weller, Peter A. Merkel, Paneez Khoury, on behalf of the EGPA Mepolizumab Open‐Label Extension study group, Arnaud Bourdin, Pascal Chanez, Anoop Chauhan, Vincent Cottin, Gerald Gleich, Berhnard Hellmich, Tomonori Ishii, David Jayne, Jean‐Emmanuel Kahn, Peter Kern, Nader Khalidi, Ina Koetter, Carol Langford, Amy Markezich, Paul Monach, Shamsa Naveed, Peter Oelzner, Kenneth Pinna, Xavier Puechal, Emory H. Robinette, Florence Roufosse, Reinhard Voll, Andrew Schafer, Kaharu Sumino, Masami Taniguchi, Phillip Lieberman   +34 more
wiley   +1 more source

The role of calcium‐sensitive receptor in ovalbumin‐induced airway inflammation and hyperresponsiveness in juvenile mice with asthma

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1203-1212, December 2022., 2022
Abstract The role of the calcium‐sensitive receptor (CaSR) was assessed in a juvenile mouse model of asthma induced by ovalbumin (OVA). The experiment was divided into normal control, OVA, and OVA +2.5/5 mg/kg NPS2143 (a CaSR antagonist) groups.
Zhao‐Yan Xiang, Di‐Di Tao
wiley   +1 more source

Radiosynthesis and evaluation of a 68Ga‐labeled brominated benzamide derivative for detection of melanoma in small animals

Bulletin of the Korean Chemical Society, EarlyView.
Malignant melanoma has the highest mortality rate among skin cancers due to its aggressiveness and metastatic potential, and early diagnosis is important because treatment options are limited. We synthesized a brominated benzamide derivative labeled with 68Ga and evaluated its biological properties as a PET imaging probe.
Dagyeong Hong, Chaewon Lee, Boreum Song, Eunsu Kim, Yejin Seo, Jiyu Kim, Wookyeong Jeong, Seong‐Young Kwon, Dong‐Yeon Kim, Ayoung Pyo   +9 more
wiley   +1 more source

3D‐cultured BMSC exosomes improve cerebral ischemia/reperfusion injury‐induced neuronal apoptosis by regulating the microglia polarization

BMEMat, EarlyView.
The study reveals that microglial activation significantly contributes to neuroinflammation following cerebral ischemia‐reperfusion injury. It demonstrates that utilizing GelMA hydrogel for three‐dimensional culture of bone marrow‐derived mesenchymal stem cells (BMSCs) enhances the efficacy of BMSC‐derived exosomes in regulating microglial polarization
Yuming Li, Hao Shang, Qiong Zhang, Xianyong Yin, Zihao Liu, Yuqing Fang, Kyubae Lee, Huayang Zhao, Zhihai Wang, Hongbo Zhao, Xiaofeng Wang, Shengjie Li, Shan Wang, Tao Xin   +13 more
wiley   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Local vasoregulative interventions impact drug concentrations in the skin after topical laser‐assisted delivery

Lasers in Surgery and Medicine, Volume 54, Issue 10, Page 1288-1297, December 2022., 2022
Abstract Introduction The ability of ablative fractional lasers (AFL) to enhance topical drug uptake is well established. After AFL delivery, however, drug clearance by local vasculature is poorly understood. Modifications in vascular clearance may enhance AFL‐assisted drug concentrations and prolong drug dwell time in the skin.
Emily Wenande, Sarat Chandra Gundavarapu, Joshua Tam, Brijesh Bhayana, Carina N. Thomas, William A. Farinelli, Benjamin J. Vakoc, R. Rox Anderson, Merete Haedersdal   +8 more
wiley   +1 more source

EFFECT OF NITROUS OXIDE INHALATION ON CHANGES IN SENSORY BLOCK IN PATIENTS UNDERGOING SPINAL ANESTHESIA

Journal of Research in Medical Sciences, 2003
Introduction: Spinal Anesthesia is a successful method for most surgical procedures on lower extremities and lower abdomen. Occasionally the duration of sensory blockade is shorter than the duration of the surgical procedures resulting in painful stress ...
SEYED JALAL HASHEMI, P KASHEFI, M.M HALAVI   +2 more
doaj  

Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

Cancer Communications, EarlyView.
Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grade serous ovarian cancer (HGSOC), but the underlying ...
Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu   +11 more
wiley   +1 more source

Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation

Cancer Communications, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming.
Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo   +6 more
wiley   +1 more source