Results 231 to 240 of about 73,729 (291)

Predicting Anxiety in Children Aged 2–6 During Preoperative Anesthesia Consultation—A Prospective Observational Study

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Background Preoperative Anxiety in Young Children Is Common and Can Lead to Adverse Outcomes. In Clinical Routine, Anesthesiologists Must Often Predict Anxiety Based on Limited Interaction. Aims This study aimed to evaluate the accuracy of early anxiety predictions and to identify early predictors of heightened anxiety at anesthesia induction.
Armin Sablewski   +7 more
wiley   +1 more source

Glucocorticoid‐Induced TNFR‐Related Ligand as a Biomarker for Diagnosis and Severity of Asthma in Children

open access: yesPediatric Discovery, EarlyView.
Our study demonstrates elevated GITRL expression in HDM‐exposed dendritic cells (in vitro), murine asthma models, and pediatric asthma patients, and reveals a direct association between GITRL levels and disease severity in children. ABSTRACT Currently, there are no reliable pediatric biomarkers for assessing the severity of asthma. Therefore, the study
Yuehan Li   +7 more
wiley   +1 more source

The effects of low-yield nicotine cigarette smoke inhalation on orthodontic tooth movement. [PDF]

open access: yesKorean J Orthod
Gulnar B   +5 more
europepmc   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates   +26 more
wiley   +1 more source

eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

open access: yesSmall, EarlyView.
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha   +6 more
wiley   +1 more source

Hydrogel Microneedle Array‐Based Transdermal Dressing System for Multiplexed Assessment and Intelligent Therapy of Chronic Wounds

open access: yesSmall, EarlyView.
This work develops a theranostic wound microneedle dressing integrates a therapeutic MXene‐infused hydrogel with a high‐conductive sensor array enabled by a novel laser‐scribing technique. The platform actively promotes wound healing and provides antibacterial action while continuously monitoring seven key biomarkers.
Md Sharifuzzaman   +6 more
wiley   +1 more source

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