Results 231 to 240 of about 616,628 (329)

Comparison of inhalation and total intravenous anesthesia on inflammatory markers in microdiscectomy: a double-blind study. [PDF]

open access: yesBMC Anesthesiol
Yediyıldız MB   +7 more
europepmc   +1 more source

Surface‐Engineering of Pancreatic Islets with Chitosan Microparticles to Inhibit IBMIR in Islet Xenotransplantation

open access: yesSmall, EarlyView.
A novel surface engineering approach using chitosan microparticles (CSMP) is developed to enable stable islet conjugation and high‐capacity heparin (HEP) loading. The resulting HEP/CSMP‐islets maintain viability and function and significantly suppress IBMIR after intraportal transplantation in diabetic mice. This strategy offers a simple, biocompatible
Manju Shrestha   +11 more
wiley   +1 more source

Targeted Nanocomplex Delivery for Protecting Vascular Integrity and Enhancing Anticancer Effects in Hepatocellular Carcinoma

open access: yesSmall Science, EarlyView.
Herein, a liver‐targeted nanohybrid formulation, SGLC/DOX@AG, is developed to enhance doxorubicin delivery and reduce vascular toxicity in hepatocellular carcinoma (HCC) treatment. Incorporating an albumin–glucosamine lipid complex, the system shows potent anticancer effects and minimized side effects across in vitro, in vivo, and cancer‐on‐a‐chip ...
Hyelim Kim   +11 more
wiley   +1 more source

Neuroprotective effects of remote limb ischemic preconditioning through enhanced cerebral blood flow via activation of the PI3K/AKT pathway in ischemic stroke

open access: yesVIEW, EarlyView.
Stroke is a leading cause of death and disability worldwide, often due the inadequate restoration of cerebral blood flow following vascular recanalization. Our study demonstrates that a simple technique called RLIPC (remote limb ischemic preconditioning), which involves briefly restricting blood flow in a limb, protects the brain during a stroke by ...
Chaoran Dou   +8 more
wiley   +1 more source

Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies

open access: yesVIEW, EarlyView.
Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan   +6 more
wiley   +1 more source

Sevoflurane induces the inattention, cognitive impairment, and motor dysfunction by hypermethylation of retinoic acid receptor α in the medial prefrontal cortex of neonatal mice

open access: yesVIEW, EarlyView.
The mechanisms underlying neurodevelopmental toxicity induced by repeated exposure to general anesthesia in neonatal mice remain to be fully elucidated. In this study, neonatal mice were exposed to sevoflurane on postnatal days 6, 8, and 10. On postnatal day 30, the medial prefrontal cortex was collected for whole‐genome bisulfite sequencing and RNA ...
Yu Hou   +10 more
wiley   +1 more source

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