Results 111 to 120 of about 443,909 (310)

Exhaled propofol monitoring for plasma drug prediction in rats

Frontiers in Veterinary Science
While propofol can be detected in exhaled breath in rats, robust evidence supporting its correlation with plasma concentrations or its use in predicting plasma levels remains lacking. In this study, eighteen mechanically ventilated rats were divided into
Xiaoxiao Li, Xiaoxiao Li, Pan Chang, Pan Chang, Xing Liu, Xing Liu, Yi Kang, Yi Kang, Zhongjun Zhao, Yixiang Duan, Wensheng Zhang, Wensheng Zhang   +11 more
doaj   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

A review on the pharmacology, pharmacokinetics and toxicity of sophocarpine

Frontiers in Pharmacology
Sophocarpine is a natural compound that belongs to the quinolizidine alkaloid family, and has a long history of use and widespread distribution in traditional Chinese herbal medicines such as Sophora alopecuroides L., Sophora flavescens Ait., and Sophora
Shichao Wei, Shichao Wei, Junshen Xiao, Junshen Xiao, Feng Ju, Feng Ju, Jin Liu, Zhaoyang Hu   +7 more
doaj   +1 more source

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, EarlyView.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source

Causality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study

Frontiers in Endocrinology
BackgroundEvidence indicates a negative link between glucosamine and age-related cognitive decline and sarcopenia. However, the causal relationship remains uncertain.
Yi Kang, Yi Kang, Yidan Tang, Yidan Tang, Weishuang Kong, Tao Zhu, Tao Zhu, Guo Chen, Guo Chen   +8 more
doaj   +1 more source

LOCAL ANESTHESIA. [PDF]

Journal of the American Medical Association, 1908
Except for strictly minor operations, the use of local anesthesia in America is limited to a few clinics, though its adoption abroad is far more general. This limitation may be due, in part, to American hurry, but more probably to inexperience in the method and a certain deeprooted fear of poisoning, traceable to the days of strong cocain solutions ...
openaire   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Effect of Shenfu pretreatment on bupivacaine cardiotoxicity: An experimental study in rats

Asian Journal of Surgery, 2023
Qi Wang, Zhao Li, Jian-ming Yue, Wen-sheng Zhang   +3 more
doaj   +1 more source

Understanding the Effects of Conductive Polymer Electrode Coating on Recorded Neural Signals

Advanced Healthcare Materials, EarlyView.
Conductive polymer coatings are widely explored to improve the quality of signals recorded with chronically implanted neural electrodes, offering enhanced biocompatibility along with reduced electrode impedance. Combining computational modelling and data from PEDOT:PTS coated and PtIr electrodes in rats, we show that improvements in signal quality with
Karthik Sridhar, Judith Evers, Alexandre Trotier, Manus Biggs, Madeleine M. Lowery   +4 more
wiley   +1 more source