Results 171 to 180 of about 291,749 (265)

Postoperative Delirium Following Continuous Fascia Iliaca Compartment Block in Elderly Patients with Hip Fracture: A Case Series and Literature Review. [PDF]

Local Reg Anesth
Cao L, Xu G, Liu Z, Bai X, Li L, Gao H.
europepmc   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Butorphanol decreased the median effective concentration of ropivacaine in ultrasound-guided interscalene brachial plexus block. [PDF]

PLoS One
Su H, Li J, Zhang J, Zhang Y, Tu F.
europepmc   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

SAFE (Subarachnoid-Alternative Anaesthesia for Endoprosthesis): A Motor-Sparing and Opioid-Sparing Anesthetic Technique for Hip Fracture Surgery. [PDF]

J Clin Med
Del Buono R, Barretta R, Marsico P, Palermo C, Costa F, Pascarella G, Ranieri G, Tognù A.   +7 more
europepmc   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Postoperative Pain Outcomes and Satisfaction in Preschool Versus School-Age Children: A Prospective Multicenter Observational Study. [PDF]

Cureus
El-Tallawy SN, Pergolizzi JV, Alsubaie AT, Hegab MM, Haq AU, Abd El-Rahman AM, Helmy ML, Khan RA, Maghrabi HH, Rasheed AR, Helal DA, Tawfik AM, Elzakaziki SS, Alharbi MM, Mohyeldin AA, Delvi BM.   +15 more
europepmc   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

Elective Heparin-Free Veno-Venous Extracorporeal Membrane Oxygenation for High-Risk Airway Management in Advanced Laryngeal Tumor Obstruction: A Case Report. [PDF]

J Clin Med
Prokop J, Zuzda K, Górski WJ, Jankowski M, Brożek-Mądry E, Szułdrzyński K.   +5 more
europepmc   +1 more source